Clinical significance of K-structure : a newly discovered human corneal structure

• Project/Area Number: 19592007
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kanazawa University
• Principal Investigator: KOBAYASHI Akira Kanazawa University, 医学系, 助教 (20303274)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 生体共焦点顕微鏡 / ボウマン層 / 角膜 / K-structure

Research Abstract

本研究では、角膜生体共焦点顕微鏡を用いてK-structureの2次元構造を明らかにし、それらがanterior corneal mosaic(ACM)と一致することから、K-structureがACMの解剖学的原因であることが強く示唆された。また、ボウマン層が障害されている疾患ではK-structureやACMが消失していることが判明し、ACMはボウマン層の健常性の指標となり得ることを証明した。

Research Products

• [Journal Article] In vivo laser confocal microscopy after non-Descemet's stripping automated endothelial keratoplasty. (2009)
  • Author(s): Kobayashi A, Yokogawa H, Sugiyama K.
  • Journal Title: Ophthalmology 116 Pages: 1306-1313
  • Peer Reviewed
• [Journal Article] In vivo laser confocal microscopy findings and mutational analysis for Schnyder's crystalline corneal dystrophy. (2009)
  • Author(s): Kobayashi A, Fujiki K, Murakami A, Sugiyama K.
  • Journal Title: Ophthalmology 116 Pages: 1029-1037
  • Peer Reviewed
• [Journal Article] In vivo laser confocal microscopy findings and mutational analysis for Schnyder's crystalline corneal dystrophy. (2009)
  • Author(s): Kobayashi A, Fujiki K, Murakami A., Sugiyama K.
  • Journal Title: Ophthalmology 116 Pages: 1029-1037
  • Peer Reviewed
• [Journal Article] In vivo laser confocal microscopic analysis of murine cornea and lens microstructures. (2008)
  • Author(s): Yuasa M, Kobayashi A, Yokogawa H, Sugiyama K.
  • Journal Title: Ophthalmic Surg Lasers Imaging 39 Pages: 391-396
  • Peer Reviewed
• [Journal Article] Mapping of normal corneal K-structures by in vivo laser confocal microscopy. (2008)
  • Author(s): Yokogawa H, Kobayashi A, Sugiyama K.
  • Journal Title: Cornea 27 Pages: 879-883
  • Peer Reviewed
• [Journal Article] In vivo laser confocal microscopy findings of cryopreserved and fresh human amniotic membrane. (2008)
  • Author(s): Kobayashi A, Sugiyama K, Li W, Tseng SC
  • Journal Title: Ophthalmic Surg Lasers Imaging 39 Pages: 312-318
  • Peer Reviewed
• [Journal Article] Non-Descemet stripping automated endothelial keratoplasty for endothelial dysfunction secondary to argon laser iridotomy. (2008)
  • Author(s): Kobayashi A, Yokogawa H, Sugiyama K.
  • Journal Title: Am J Ophthalmol 146 Pages: 543-549
  • Peer Reviewed
• [Journal Article] In vivo and ex vivo laser confocal microscopy findings in patients with early-stage acanthamoeba keratitis. (2008)
  • Author(s): Kobayashi A, Ishibashi Y, Oikawa Y, Yokogawa H, Sugiyama K.
  • Journal Title: Cornea 27 Pages: 439-445
  • Peer Reviewed
• [Journal Article] In vivo laser confocal microscopy after descemet stripping with automated endothelial keratoplasty. (2008)
  • Author(s): Kobayashi A, Mawatari Y, Yokogawa H, Sugiyama K.
  • Journal Title: Am J Ophthalmol 145 Pages: 977-985
  • Peer Reviewed
• [Journal Article] Mapping of normal corneal K-Structures by in vivo laser confocal microscopy. (2008)
  • Author(s): Kobayashi A, Yokogawa H, Sugiyama K.
  • Journal Title: Cornea 27 Pages: 879-883
  • Peer Reviewed
• [Journal Article] In vivo laser confocal microscopic analysis of mouse cornea and lens microstructures. (2008)
  • Author(s): Yuasa M, Kobayashi A, Yokogawa H, Sugiyama K.
  • Journal Title: Ophthalmic Surg Lasers Imaging 39 Pages: 391-396
  • Peer Reviewed
• [Journal Article] In vivo and ex vivo laser confocal microscopy findings in patients with early-stage Acanthamoeba keratitis (2008)
  • Author(s): Kobayashi A, Ishibashi Y, Oikawa Y, Yokogawa H, Sugiyama K
  • Journal Title: Cornea 27 Pages: 439-445
  • Peer Reviewed
• [Journal Article] In vivo laser confocal microscopic findings of corneal stromal dystrophies. (2007)
  • Author(s): Kobayashi A, Fujiki K, Fujimaki T, Murakami A, Sugiyama K.
  • Journal Title: Arch Ophthalmol 125 Pages: 1168-1173
  • Peer Reviewed
• [Journal Article] In vivo laser confocal microscopy findings of corneal stromal dystrophies (2007)
  • Author(s): Kobayashi A, Fujiki K, Fujimaki T, Murakami A, Sugiyama K.
  • Journal Title: Archives of Ophthalmology 125 Pages: 1168-1173
  • Peer Reviewed
• [Journal Article] Evaluation of visual acuity and color vision in normal human eyes with a sutureless temporary amniotic membrane patch (2007)
  • Author(s): Ijiri S, Kobayashi A, Sugiyama K, Tseng SCG.
  • Journal Title: American Journal of Ophthalmology 144 Pages: 938-942
  • Peer Reviewed
• [Presentation] 生体共焦点顕微鏡を用いた角結膜疾患の研究(日本角膜学会学術奨励賞受賞記念講演) (2008)
  • Author(s): 小林顕
  • Organizer: 第32回角膜カンファランス
  • Place of Presentation: 千葉県東京ベイホテル東急
• [Presentation] ボウマン層ジストロフィのレーザー生体共焦点顕微鏡所見. (2007)
  • Author(s): 小林顕、杉山和久
  • Organizer: 第111回日本眼科学会総会
  • Place of Presentation: 大阪府大阪国際会議場
• [Presentation] 生体共焦点レーザー顕微鏡(HRT2-RCM)によるマウス角膜および水晶体微細構造の生体観察. (2007)
  • Author(s): 湯浅雅史、小林顕、横川英明、杉山和久
  • Organizer: 第111回日本眼科学会総会
  • Place of Presentation: 大阪府大阪国際会議場
• [Presentation] Mapping of the normal human corneal anterior collagen fiber bundles by in vivo laser scanning confocal microscopy. (2007)
  • Author(s): Yokogawa H, Kobayashi A, Sugiyama K.
  • Organizer: 78th Association for Reserch in Vision and Ophthalmology
  • Place of Presentation: Fort Lauderdale, USA Convention Center
• [Presentation] Mapping of the normal human corneal anterior collagen fiber bundles by in vivo laser scanning confocal microscopy (2007)
  • Author(s): Yokogawa H, Kobayashi A, Sugiyama K.
  • Organizer: 78th Association for Reserch in Vision and Ophth almology
  • Place of Presentation: Fort Lauderdale,USA