Methodology to examine the local choroidal circulation in the choriocapillaris-evaluation of the adverse effect of the photodynamic therapy

• Project/Area Number: 19592015
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kyoto University
• Principal Investigator: TSUJIKAWA Akitaka Kyoto University, 医学研究科, 助教 (40402846)
• Co-Investigator(Kenkyū-buntansha): OTANI Atsushi 京都大学, 医学研究科, 助教 (30314222) ; TAMURA Hiroshi 京都大学, 医学研究科, 助教 (40418760)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 加齢黄斑変性 / 光線力学療法 / 脈絡膜循環 / リポソーム / 脈絡膜新生血管

Research Abstract

温度感受性リポソームにフルオレセインを封入し、脈絡膜の循環動態を解析できるシステムを確立した。さらに、一定の作成効率で温度感受性リポソームの作成が可能となり、定量的な評価が可能となった。また、verteporfinを用いた光線力学療法の脈絡膜循環への影響を評価するため、ラット等の実験動物に対して通常ヒトに対して用いられる量のビスダインを注射後、レーザーを照射し、光線力学療法を施行したが、脈絡膜毛細血管の狭小化や閉塞などの器質的な循環障害や、流入遅延などの機能的な変化も見られなかった。

Research Products

• [Journal Article] Recurrence of polypoidal choroidal vasculopathy after photodynamic therapy (2008)
  • Author(s): Yamashiro K, Tsujikawa A, Nishida A, Mandai M, Kurimoto Y
  • Journal Title: Jpn J Ophthalmol 52 Pages: 457-462
  • NAID: 10025148855
• [Journal Article] Photodynamic therapy combined with low-dose intravitreal triamcinolone acetonide for age-related macular degeneration refractory to photodynamic therapy alone (2008)
  • Author(s): Iwama D, Otani A, Sasahara M, Yodoi Y, Gotoh N, Tamura H, Tsujikawa A, Yoshimura N.
  • Journal Title: Br J Ophthalmol 92 Pages: 1352-1356
• [Journal Article] Two-year results of photodynamic therapy for polypoidal choroidal vasculopathy (2008)
  • Author(s): Kurashige Y, Otani A, Sasahara M, Yodoi Y, Tamura H, Tsujikawa A, Yoshimura N.
  • Journal Title: Am J Ophthalmol 146 Pages: 513-519
• [Journal Article] Chorioretinal anastomosis after photodynamic therapy for polypoidal choroidal vasculopathy : CRA after PDT for PCV (2008)
  • Author(s): Yodoi Y, Tsujikawa A, Otani A, Aikawa H, Yoshimura N
  • Journal Title: Int Ophthalmol 28 Pages: 297-299
• [Journal Article] Recurrence of polypoidal choroidal vasculopathy after photodynamic therapy. (2008)
  • Author(s): Yamashiro K, Tsujikawa A, Nishida A, Mandai M, Kurimoto Y.
  • Journal Title: Jpn J Ophthalmol. 52 Pages: 457-62
  • NAID: 10025148855
  • Peer Reviewed
• [Journal Article] Photodynamic therapy combined with low-dose intravitreal triaracinolone acetonide for age-related macular degeneration refractory to photodynamic therapy alone. (2008)
  • Author(s): Iwama D, Otani A, Sasahara M, Yodoi Y, Gotoh N, Tamura H, Tsujikawa A, Yoshimura N.
  • Journal Title: Br J Ophthalmol. 92 Pages: 1352-6
  • Peer Reviewed
• [Journal Article] Two-year results of photodynamic therapy for polypoidal choroidal vasculopathy. (2008)
  • Author(s): Kurashige Y, Otani A, Sasahara M, Yodoi Y, Tamura H, Tsujikawa A, Yoshimura N.
  • Journal Title: Am J Ophthalmol. 146 Pages: 513-9
  • Peer Reviewed
• [Journal Article] Central retinal sensitivity measured with the micro perimeter 1 after photodynamic therapy for polypoidal choroidal vasculopathy (2007)
  • Author(s): Yodoi Y, Tsujikawa A, Kameda T, Otani A, Tamura H, Mandai M, Yoshimura N.
  • Journal Title: Am J Ophthalmol 143 Pages: 984-994
• [Journal Article] Determinants of patient satisfaction with photodynamic therapy for neovascular age-related macular degeneration or polypoidal choroidal vasculopathy (2007)
  • Author(s): Yamashiro K, Tsujikawa A, Nishida A, Kurimoto Y
  • Journal Title: Jpn J Ophthalmol 51 Pages: 368-374
  • NAID: 10019830000
• [Journal Article] Indocyanine green angiography : guided photodynamic therapy for polypoidal choroidal vasculopathy (2007)
  • Author(s): Otani A, Sasahara M, Yodoi Y, Aikawa H, Tamura H, Tsujikawa A, Yoshimura N.
  • Journal Title: Am J Ophthalmol 144 Pages: 7-14
• [Journal Article] Hemorrhagic complications after photodynamic therapy for polypoidal choroidal vasculopathy (2007)
  • Author(s): Hirami Y, Tsujikawa A, Otani A, Yodoi Y, Aikawa H, Mandai M, Yoshimura N.
  • Journal Title: Retina 27 Pages: 335-341
• [Presentation] 光線力学療法を施行し長期経過観察した加齢黄斑変性の網膜断層所見と視力の相関 (2008)
  • Author(s): 林寿子, 山城健児, 辻川明孝, 太田将文, 田村寛, 大谷篤史, 吉村長久
  • Organizer: 第62回日本臨床眼科学会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-26
• [Presentation] 光線力学療法を施行し長期経過観察しか加齢黄斑変性の網膜断層所見と視力の相関 (2008)
  • Author(s): 林寿子, 山城健児, 辻川明孝, 太田将文, 田村寛, 大谷篤史, 吉村長久
  • Organizer: 第62回日本臨床眼科学会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-26