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Methodology to examine the local choroidal circulation in the choriocapillaris-evaluation of the adverse effect of the photodynamic therapy

Research Project

Project/Area Number 19592015
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionKyoto University

Principal Investigator

TSUJIKAWA Akitaka  Kyoto University, 医学研究科, 助教 (40402846)

Co-Investigator(Kenkyū-buntansha) OTANI Atsushi  京都大学, 医学研究科, 助教 (30314222)
TAMURA Hiroshi  京都大学, 医学研究科, 助教 (40418760)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords加齢黄斑変性 / 光線力学療法 / 脈絡膜循環 / リポソーム / 脈絡膜新生血管
Research Abstract

温度感受性リポソームにフルオレセインを封入し、脈絡膜の循環動態を解析できるシステムを確立した。さらに、一定の作成効率で温度感受性リポソームの作成が可能となり、定量的な評価が可能となった。また、verteporfinを用いた光線力学療法の脈絡膜循環への影響を評価するため、ラット等の実験動物に対して通常ヒトに対して用いられる量のビスダインを注射後、レーザーを照射し、光線力学療法を施行したが、脈絡膜毛細血管の狭小化や閉塞などの器質的な循環障害や、流入遅延などの機能的な変化も見られなかった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (13 results)

All 2008 2007

All Journal Article (11 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] Recurrence of polypoidal choroidal vasculopathy after photodynamic therapy2008

    • Author(s)
      Yamashiro K, Tsujikawa A, Nishida A, Mandai M, Kurimoto Y
    • Journal Title

      Jpn J Ophthalmol 52

      Pages: 457-462

    • NAID

      10025148855

    • Related Report
      2008 Final Research Report
  • [Journal Article] Photodynamic therapy combined with low-dose intravitreal triamcinolone acetonide for age-related macular degeneration refractory to photodynamic therapy alone2008

    • Author(s)
      Iwama D, Otani A, Sasahara M, Yodoi Y, Gotoh N, Tamura H, Tsujikawa A, Yoshimura N.
    • Journal Title

      Br J Ophthalmol 92

      Pages: 1352-1356

    • Related Report
      2008 Final Research Report
  • [Journal Article] Two-year results of photodynamic therapy for polypoidal choroidal vasculopathy2008

    • Author(s)
      Kurashige Y, Otani A, Sasahara M, Yodoi Y, Tamura H, Tsujikawa A, Yoshimura N.
    • Journal Title

      Am J Ophthalmol 146

      Pages: 513-519

    • Related Report
      2008 Final Research Report
  • [Journal Article] Chorioretinal anastomosis after photodynamic therapy for polypoidal choroidal vasculopathy : CRA after PDT for PCV2008

    • Author(s)
      Yodoi Y, Tsujikawa A, Otani A, Aikawa H, Yoshimura N
    • Journal Title

      Int Ophthalmol 28

      Pages: 297-299

    • Related Report
      2008 Final Research Report
  • [Journal Article] Recurrence of polypoidal choroidal vasculopathy after photodynamic therapy.2008

    • Author(s)
      Yamashiro K, Tsujikawa A, Nishida A, Mandai M, Kurimoto Y.
    • Journal Title

      Jpn J Ophthalmol. 52

      Pages: 457-62

    • NAID

      10025148855

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photodynamic therapy combined with low-dose intravitreal triaracinolone acetonide for age-related macular degeneration refractory to photodynamic therapy alone.2008

    • Author(s)
      Iwama D, Otani A, Sasahara M, Yodoi Y, Gotoh N, Tamura H, Tsujikawa A, Yoshimura N.
    • Journal Title

      Br J Ophthalmol. 92

      Pages: 1352-6

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two-year results of photodynamic therapy for polypoidal choroidal vasculopathy.2008

    • Author(s)
      Kurashige Y, Otani A, Sasahara M, Yodoi Y, Tamura H, Tsujikawa A, Yoshimura N.
    • Journal Title

      Am J Ophthalmol. 146

      Pages: 513-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Central retinal sensitivity measured with the micro perimeter 1 after photodynamic therapy for polypoidal choroidal vasculopathy2007

    • Author(s)
      Yodoi Y, Tsujikawa A, Kameda T, Otani A, Tamura H, Mandai M, Yoshimura N.
    • Journal Title

      Am J Ophthalmol 143

      Pages: 984-994

    • Related Report
      2008 Final Research Report
  • [Journal Article] Determinants of patient satisfaction with photodynamic therapy for neovascular age-related macular degeneration or polypoidal choroidal vasculopathy2007

    • Author(s)
      Yamashiro K, Tsujikawa A, Nishida A, Kurimoto Y
    • Journal Title

      Jpn J Ophthalmol 51

      Pages: 368-374

    • NAID

      10019830000

    • Related Report
      2008 Final Research Report
  • [Journal Article] Indocyanine green angiography : guided photodynamic therapy for polypoidal choroidal vasculopathy2007

    • Author(s)
      Otani A, Sasahara M, Yodoi Y, Aikawa H, Tamura H, Tsujikawa A, Yoshimura N.
    • Journal Title

      Am J Ophthalmol 144

      Pages: 7-14

    • Related Report
      2008 Final Research Report
  • [Journal Article] Hemorrhagic complications after photodynamic therapy for polypoidal choroidal vasculopathy2007

    • Author(s)
      Hirami Y, Tsujikawa A, Otani A, Yodoi Y, Aikawa H, Mandai M, Yoshimura N.
    • Journal Title

      Retina 27

      Pages: 335-341

    • Related Report
      2008 Final Research Report
  • [Presentation] 光線力学療法を施行し長期経過観察した加齢黄斑変性の網膜断層所見と視力の相関2008

    • Author(s)
      林寿子, 山城健児, 辻川明孝, 太田将文, 田村寛, 大谷篤史, 吉村長久
    • Organizer
      第62回日本臨床眼科学会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-26
    • Related Report
      2008 Final Research Report
  • [Presentation] 光線力学療法を施行し長期経過観察しか加齢黄斑変性の網膜断層所見と視力の相関2008

    • Author(s)
      林寿子, 山城健児, 辻川明孝, 太田将文, 田村寛, 大谷篤史, 吉村長久
    • Organizer
      第62回日本臨床眼科学会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-26
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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