The research for fibrosis and retinal detachment in highly myopic eyes.

• Project/Area Number: 19592017
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Osaka University
• Principal Investigator: IKUNO Yasushi Osaka University, 医学系研究科, 講師 (50294096)
• Co-Investigator(Kenkyū-buntansha): GOMI Fumi 大阪大学, 医学系研究科, 講師 (80335364) ; OSHIMA Yusuke 大阪大学, 医学系研究科, 助教 (20362717) ; TANO Yasuo 大阪大学, 医学系研究科, 教授 (80093433)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 強度近視 / 網膜剥離 / 眼内線維化 / 視力障害 / 近視 / 増殖性硝子体網膜症 / 黄斑前膜 / 黄斑円孔 / 硝子体手術 / 網膜 / 内境界膜 / 線維化

Research Abstract

Macular hole and retinal detachment is one of major vision-threatening problems especially in Japan, since we have many visual impairment due to high myopia. We investigated and found that epiretinal fibrosis is a main cause of macular hole and retinal detachment by way of myopic foveoschisis. Also indocyanine green dye which is used intraoperatively for staining internal limiting membrane remains long after surgery especially in axonal flow and retinal pigment epithelium.

Research Products

• [Journal Article] Two-year visual results for older Asian women treated with photodynamic therapy or bevacizumab for myopic choroidal neovascularization (2010)
  • Author(s): Ikuno Y, Nagai Y, et al.
  • Journal Title: American Journal of Ophthalmology 49 Pages: 140-146
  • Peer Reviewed
• [Journal Article] Choroidal vascular hypofluorescence in indocyanine green angiography of high myopia (2009)
  • Author(s): Sayanagi K, Ikuno Y, Soga K, Wakabayashi T, Tsujikawa M, Tano Y.
  • Journal Title: Br J Ophthalmol 93 Pages: 1687-90
  • Peer Reviewed
• [Journal Article] Intravitreal bevacizumab vs sub-tenon triamcinolone acetonide for choroidal neovascularization attributable to pathologic myopia (2009)
  • Author(s): Wakabayashi T, Ikuno Y, Gomi F, Hamasaki T, Tano Y.
  • Journal Title: Am J Ophthalmol 148 Pages: 591-596
  • Peer Reviewed
• [Journal Article] Retinal and choroidal biometry in highly myopic eyes with spectral-domain optical coherence tomography (2009)
  • Author(s): Ikuno Y, Tano Y.
  • Journal Title: Invest Ophthalmol Vis Sci 50 Pages: 3876-80
  • Peer Reviewed
• [Journal Article] Presumed vascular traction-associated recurrence of retinal detachment in patients with myopic macular hole (2009)
  • Author(s): Sayanagi K, Oshima Y, Ikuno Y, Tano Y.
  • Journal Title: Ophthalmic Surg Lasers Imaging 40 Pages: 60-4
  • Peer Reviewed
• [Journal Article] Intravitreal bevacizumab for choroidal neovascularization attributable to pathological myopia: one-year results. (2009)
  • Author(s): Ikuno Y, Sayanagi K, Soga K, Sawa M, Tsujikawa M, Gomi F, Tano Y.
  • Journal Title: Am J Ophthalmol 147 Pages: 94-100
  • Peer Reviewed
• [Journal Article] Marginal crack after intravitreal bevacizumab for myopic choroidal neovascularization (2009)
  • Author(s): Sayanagi K, Ikuno Y, Soga K, Wakabayashi T, Tano Y.
  • Journal Title: Acta Ophthalmol 87 Pages: 460-3
  • Peer Reviewed
• [Journal Article] トリアムシノロンからbevacizumabに治療を転換した近視性血管新生黄斑症 (2009)
  • Author(s): 上野千佳子, 生野恭司、田野保雄
  • Journal Title: 眼科臨床紀要 Pages: 321-325
  • NAID: 10024807216
  • Peer Reviewed
• [Journal Article] Intravitreal bevacizumab for choroidal neovascularization attributable to pathological myopia : one-year results (2009)
  • Author(s): Ikuno Y, Sayanagi K, et al.
  • Journal Title: American Journal of Ophthalmology 147 Pages: 94-100
  • Peer Reviewed
• [Journal Article] Retinal and choroidal biometry in highly myopic eyes with spectral-domain optical coherence tomography (2009)
  • Author(s): Ikuno Y, Tano Y
  • Journal Title: Investigative Ophthalmology Visual Science 50 Pages: 3876-80
  • Peer Reviewed
• [Journal Article] Intravitreal bevacizumab vs sub-tenon triamcinolone acetonide for choroidal neova scularization attributable to pathologic myopia (2009)
  • Author(s): Wakabayashi T, Ikuno Y, Gomi F, Hamasaki T, Tano Y.
  • Journal Title: American Journal of Ophthalmology 148 Pages: 591-596
  • Peer Reviewed
• [Journal Article] 【光干渉断層計(OCT)はこう読む!】近視性黄斑病変はこう読む(総説) (2009)
  • Author(s): 生野恭司
  • Journal Title: あたらしい眼科 26 Pages: 631-635
  • Peer Reviewed
• [Journal Article] Choroidal vascular hypofluorescence in indocyanine green angiography of high myopia (2009)
  • Author(s): Sayanagi K, Ikuno Y, et al.
  • Journal Title: British Journal of Ophthalmology 93 Pages: 1687-90
  • Peer Reviewed
• [Journal Article] Angiographic changes after bevacizumab (2009)
  • Author(s): Ikuno Y, Soga K, et al.
  • Journal Title: Ophthalmology 116 Pages: 2263-2263
  • Peer Reviewed
• [Journal Article] Choroidal Filling Delay in Choroidal Neovascularization due to Pathologic Myopia (2009)
  • Author(s): Wakabayashi T, Ikuno Y
  • Journal Title: British Journal of Ophthalmology (印刷中)
  • Peer Reviewed
• [Journal Article] トリアムシノロンからbevacizumabに治療を転換した近視性血管新生黄斑症 (2009)
  • Author(s): 上野千佳子, 生野恭司, ら
  • Journal Title: 眼科臨床紀要 2 Pages: 321-325
  • NAID: 10024807216
  • Peer Reviewed
• [Journal Article] Ocular Risk Factors for Choroidal Neovascularization in Pathological Myopia (2009)
  • Author(s): 生野恭司, et al.
  • Journal Title: Investigative Ophthalmology Visual Science (印刷中)
  • Peer Reviewed
• [Journal Article] Lacquer crack formation and choroidal neovascularization in pathologic myopia (2008)
  • Author(s): Ikuno Y, Sayanagi K, Soga K, Sawa M, Gomi F, Tsujikawa M, Tano Y.
  • Journal Title: Retina 28 Pages: 1124-31
  • Peer Reviewed
• [Journal Article] Foveal anatomical status and surgical results in vitrectomy for myopic foveoschisis (2008)
  • Author(s): Ikuno Y, Sayanagi K, Soga K, Oshima Y, Ohji M, Tano Y.
  • Journal Title: Jpn J Ophthalmol 52(4) Pages: 269-76
  • NAID: 10021947879
  • Peer Reviewed
• [Journal Article] Abnormal fundus autofluorescence patterns in myopic choroidal neovascularisation (2008)
  • Author(s): Sawa M, Gomi F, Tsujikawa M, Ikuno Y, Sakaguchi H, Sayanagi K, Tano Y.
  • Journal Title: Br J Ophthalmol 92 Pages: 1236-40
  • Peer Reviewed
• [Journal Article] Fundus autofluorescence related to retinal morphological and functional changes in idiopathic macular holes (2008)
  • Author(s): Wakabayashi T, Ikuno Y, Sayanagi K, Soga K, Oshima Y, Tano Y.
  • Journal Title: Acta Ophthalmol 86 Pages: 897-901
  • Peer Reviewed
• [Journal Article] Photoreceptor inner and outer segment defects in myopic foveoschisis (2008)
  • Author(s): Sayanagi K, Ikuno Y, Soga K, Tano Y.
  • Journal Title: Am J Ophthalmol 145 Pages: 902-8
  • Peer Reviewed
• [Journal Article] Foveal anatomical status and surgical results in vitrectomy for myopic foveoschisis (2008)
  • Author(s): Ikuno Y, Sayanagi K,. .. Tano Y.
  • Journal Title: Japanese Journal of Ophthalmology 52 Pages: 269-76
  • NAID: 10021947879
  • Peer Reviewed
• [Journal Article] Fundus autofluorescence related to retinal morphological and functional changes in idiopathic macular holes. (2008)
  • Author(s): Wakabayashi T, Ikuno Y,. .. Tano Y
  • Journal Title: Acta Ophthalmologica Scandinavia 86 Pages: 897-901
  • Peer Reviewed
• [Journal Article] Marginal crack after intravitreal bevacizumab for myopic choroidal neovascularization. (2008)
  • Author(s): Sayanagi K, Ikuno Y, Tano Y
  • Journal Title: Acta Ophthalmologica Scandinavia 86
  • Peer Reviewed
• [Journal Article] Photoreceptor inner and outer segment defects in myopic foveoschisis. (2008)
  • Author(s): Sayanagi K, Ikuno Y, Tano Y
  • Journal Title: American Journal of Ophthalmology 145 Pages: 902-908
  • Peer Reviewed
• [Journal Article] Lacquer crack formation and choroidal neovascularization in pathologic myopia. (2008)
  • Author(s): Ikuno Y, Ikuno Y,. .. Tano Y
  • Journal Title: RETINA 28 Pages: 1124-1131
  • Peer Reviewed
• [Journal Article] 強度近視眼の中心窩分離症の病態と分類(総説) (2008)
  • Author(s): 生野恭司
  • Journal Title: 臨床眼科 62 Pages: 270-273
• [Journal Article] Fundus autofluorescence related to retinal morphological and functional changes in idiopathic macular holes (2008)
  • Author(s): Wakabayashi T, Ikuno Y, Tano Y
  • Journal Title: Acta Ophthalmologica 未定(印刷中)
  • Peer Reviewed
• [Journal Article] Photoreceptor inner and outer segment defects in myopic foveoschisis (2008)
  • Author(s): Sayanagi K, Ikuno Y, . Tano Y
  • Journal Title: American Journal of Ophthalmology 未定(印刷中)
  • Peer Reviewed
• [Journal Article] 強度近視眼底研究における現時点での理解と問題点 (2008)
  • Author(s): 平形明人、大野京子、生野恭司(強度近視眼底研究会)
  • Journal Title: 日本眼科学会雑誌 112 Pages: 127-135
  • Peer Reviewed
• [Journal Article] Different fundus autofluorescence patterns of retinoschisis and macular hole retinal detachment in high myopia (2007)
  • Author(s): Sayanagi K, Ikuno Y, Tano Y.
  • Journal Title: Am J Ophthalmol 144 Pages: 299-301
  • Peer Reviewed
• [Journal Article] Residual indocyanine green fluorescence pattern after vitrectomy with internal limiting membrane peeling in high myopia (2007)
  • Author(s): Sayanagi K, Ikuno Y, Soga K, Sawa M, Tano Y.
  • Journal Title: Am J Ophthalmol 144 Pages: 600-7
  • Peer Reviewed
• [Journal Article] Residual indocyanine green fluorescence pattern after vitrectomy with internal limiting membrane peeling in high myopia. (2007)
  • Author(s): Sayanagi K, Ikuno Y, .Tano Y.
  • Journal Title: American Journal of Ophthalmology 144 Pages: 600-607
  • Peer Reviewed
• [Journal Article] Different fundus autofluorescence patterns of retinoschisis and macular hole retinal detachment in high myopia. (2007)
  • Author(s): Sayanagi K, Ikuno Y, Tano Y.
  • Journal Title: American Journal of Ophthalmology 144 Pages: 299-301
  • Peer Reviewed
• [Journal Article] 【網膜硝子体診療の進歩】治療手技の進歩 高度近視の黄斑病変 (2007)
  • Author(s): 生野恭司
  • Journal Title: あたらしい眼科 24 Pages: 227-232
  • Peer Reviewed
• [Presentation] 黄斑円孔網膜剥離とその類縁疾患における画像診断の役割 (2010)
  • Author(s): 生野恭司
  • Organizer: 第33回日本眼科手術学会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2010-01-22
• [Presentation] Punctate Inner Choroidopathy and the Visual Outcome After Avastin for Secondary CNV (2009)
  • Author(s): Jo Y, Ikuno Y, Tano Y.
  • Organizer: 2009 American Academy of Ophthalmology Annual Meeting San Francisco
  • Place of Presentation: U.S.A.
  • Year and Date: 2009-10-26
• [Presentation] Punctate Inner Choroidopathy and the Visual Outcome After Avastin for Secondary CNV (2009)
  • Author(s): Jo Y, Ikuno Y, et al.
  • Organizer: American Academy of Ophthalmology Annual Meeting
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2009-10-26
• [Presentation] 近視性脈絡膜新生血管に対するbevacizumab硝子体内投与後の脈絡膜厚の変化 (2009)
  • Author(s): 城友香理、生野恭司
  • Organizer: 第63回日本臨床眼科学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-10-09
• [Presentation] 強度近視合併症における疾患概念の進歩 (2009)
  • Author(s): 生野恭司
  • Organizer: 第63回日本臨床眼科学会シンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 2009-10-09
• [Presentation] Current concepts and management of myopic foveoschisis (2009)
  • Author(s): 生野恭司
  • Organizer: 9^<th> EURETINA meeting
  • Place of Presentation: Nice, France
  • Year and Date: 2009-05-16
• [Presentation] Clinical application of 1060nm-OCT on various posterior retinal/choroidal diseases (2009)
  • Author(s): 生野恭司
  • Organizer: 2009 ARVO annual meeting
  • Place of Presentation: Fort Lauderdale, FL, USA
  • Year and Date: 2009-05-04
• [Presentation] スペクトラルドメイン光干渉断層計を用いた強度近視眼の後眼部生体計測 (2009)
  • Author(s): 生野恭司、田野保雄
  • Organizer: 第113回日本眼科学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-17
• [Presentation] Visual outcomes after intravitreal bevacizumab and subtenon triamcinolone acetonide for myopic choroidal neovascularization (2008)
  • Author(s): Wakabayashi T, Ikuno Y,. .. Tano Y
  • Organizer: 2008 American Academy of Ophthalmology Annual meeting
  • Place of Presentation: アトランタ(米国)
  • Year and Date: 2008-11-11
• [Presentation] Indocyanine green angiography using confocal system in myopic choroidal neovascularization (2008)
  • Author(s): Ikuno Y, Sayanagi K,. .. Tano Y
  • Organizer: 2008 American Academy of Ophthalmology Annual meeting
  • Place of Presentation: アトランタ(米国)
  • Year and Date: 2008-11-11
• [Presentation] Postoperative Changes in Fundus Autofluorescence in Myopic Foveoschisis and Macular Hole and Retinal Detachment (2007)
  • Author(s): Sayanagi K, Ikuno Y, .Tano Y
  • Organizer: 2007 American Academy of Ophthalmology Annual meeting
  • Place of Presentation: ニューオリンズ(米国)
  • Year and Date: 2007-11-11
• [Presentation] Intravitreal bevacizumab(Avastin)injection for choroidal neovascularization due to pathological myopia (2007)
  • Author(s): Ikuno Y, Sayanagi K, .Tano Y
  • Organizer: 2007 American Academy of Ophthalmology Annual meeting
  • Place of Presentation: ニューオリンズ(米国)
  • Year and Date: 2007-11-11
• [Presentation] Postoperative Changes in Fundus Autofluorescence in Myopic Foveoschisis and Macular Hole and Retinal Detachment (2007)
  • Author(s): Sayanagi K, Ikuno Y, Tano Y.
  • Organizer: 2007 American Academy of Ophthalmology Annual Meeting
  • Place of Presentation: New Orleans, U.S.A.
  • Year and Date: 2007-10-09
• [Presentation] Intravitreal bevacizumab (Avastin) injection for choroidal neovascularization due to pathological myopia (2007)
  • Author(s): Ikuno Y, Sayanagi K, Tano Y.
  • Organizer: 2007 American Academy of Ophthalmology Annual Meeting
  • Place of Presentation: New Orleans, U.S.A.
  • Year and Date: 2007-10-09
• [Book] 【眼底画像所見を読み解く】変性近視 網脈絡膜萎縮 (2008)
  • Author(s): 生野恭司
  • Total Pages: 8
  • Publisher: 文光堂
• [Book] みんなの硝子体手術 (2007)
  • Author(s): 生野恭司
  • Publisher: 文光堂
• [Book] みんなの硝子体手術 (2007)
  • Author(s): 佐柳香織、生野恭司
  • Publisher: 文光堂
• [Book] 【みんなの硝子体手術】網膜硝子体手術 変性近視の硝子体手術 (2007)
  • Author(s): 生野恭司
  • Publisher: 文光堂
• [Book] 【みんなの硝子体手術】0ne point advice変性近視における網膜前膜診断の難しさ (2007)
  • Author(s): 佐柳香織、生野恭司
  • Publisher: 文光堂
• [Patent(Industrial Property Rights)] 軸性近視の予防または治療剤 (2008)
  • Inventor(s): 生野恭司、田野保雄
  • Industrial Property Rights Holder: 大阪大学
  • Industrial Property Number: 2008-190673
  • Filing Date: 2008-07-24
• [Patent(Industrial Property Rights)] 軸性近視の予防・治療剤 (2008)
  • Inventor(s): 生野恭司, 他
  • Industrial Property Rights Holder: 大阪大学
  • Industrial Property Number: 2008-190673
  • Filing Date: 2008-07-24