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Pathogenesis of Age-related macular degeneration-lipid oxidation in photoreceptors and roles of macrophages

Research Project

Project/Area Number 19592019
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionOsaka University

Principal Investigator

KAMEI Motohiro  Osaka University, 医学系研究科, 准教授 (40281125)

Co-Investigator(Kenkyū-buntansha) TANO Yasuo  大阪大学, 医学系研究科, 教授 (80093433)
GOMI Fumi  大阪大学, 医学系研究科, 講師 (80335364)
TSUJIKAWA Motokazu  大阪大学, 医学系研究科, 講師 (70419472)
SAKAGUCHI Hirokazu  大阪大学, 医学系研究科, 助教 (80379172)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords加齢黄斑変性 / 視細胞 / 脂質酸化 / マクロファージ / 光ストレス / 慢性炎症 / 酸化ストレス / 網膜色素上皮細胞 / MCP-1
Research Abstract

光照射により網膜におけるリン脂質酸化、MCP-1発現誘導、マクロファージ集積が見られることを見出した。また、invitroで酸化リン脂質がMCP-1発現を誘導していることを確認した。さらに、網膜下に酸化リン脂質を投与したところ、加齢黄斑変性の特徴的病変である脈絡膜新生血管を誘導することに成功した。MCP-1 ノックアウトマウスへの投与では、脈絡膜新生血管は生じなかったことより、光ストレス→リン脂質酸化→MCP-1 発現→マクロファージ集積→脈絡膜新生血管誘導と言う機序が存在する可能性を示唆できた

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (23 results)

All 2008 2007 Other

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (6 results)

  • [Journal Article] Tissue Plasminogen Activator-Assisted Vitrectomy : Surgical Drainage of SubmacularHemorrhage Developments inOphthalmology2008

    • Author(s)
      Kamei M, Tano Y
    • Journal Title

      (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complications in patients after intravitreal injectionof bevacizumab2008

    • Author(s)
      Shima C, Sakaguchi H, Gomi F, Kamei M, Ikuno Y, Oshima Y, Sawa M, Tsujikawa M,Kusaka S, Tano Y
    • Journal Title

      Acta Ophthalmol Scand 86(4)

      Pages: 372-6

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intravitreal bevacizumab to treat irisneovascularization and neovascularglaucoma secondary to ischemic retinaldiseases in 41 consecutive cases2008

    • Author(s)
      Wakabayashi T, Oshima Y, Sakaguchi H, Ikuno Y, Miki A, Gomi F, Otori Y, KameiM, Kusaka S, Tano Y
    • Journal Title

      Ophthalmology 115

      Pages: 1571-1580

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of Intravitreal bevacizumab forpolypoidal choroidal vasculopathy2008

    • Author(s)
      Gomi F, Sawa M, Sakaguchi H, Tsujikawa M, Oshima Y, Kamei M, Tano Y
    • Journal Title

      Br J Ophthalmol 92

      Pages: 70-73

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pegaptanib Sodium Multi-center Study Group2008

    • Author(s)
      Tano Y
    • Journal Title

      Pegaptanib sodium one-year treatment study for neovascularage-related macular degeneration.Nippon Ganka Gakkai Zasshi 112

      Pages: 590-600

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] One-Year Outcomes of Photodynamic Therapy in Age-Related MacularDegeneration and Polypoidal ChoroidalVasculopathy in Japanese Patients2008

    • Author(s)
      Gomi F, Ohji M, Sayanagi K, Sawa M, Sakaguchi H, Oshima Y, Ikuno Y, Tano Y
    • Journal Title

      Ophthalmology 115

      Pages: 141-6

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polypoidal choroidal vasculopathy and treatments2008

    • Author(s)
      Gomi F, Tano Y
    • Journal Title

      Curr Opin Ophthalmol 19(3)

      Pages: 208-12

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy and safety of one intravitreal injection of bevacizumab in diabetic macular oedema.2008

    • Author(s)
      Fang X, Sakaguchi H, Gomi F, Oshima Y, Sawa M, Tsujikawa M, Ikuno Y, Kamei M, Kusaka S, Tano Y.
    • Journal Title

      Acta Ophthalmol. 86(7)

      Pages: 800-805

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased retinal toxicity of intravitreal tissue plasminogen activator in a central retinal veinocclusion model.2008

    • Author(s)
      Yamamoto T, Kamei M. Kunavisarut P, Suzuki M, Tano Y.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol. 264(4)

      Pages: 509-514

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intravitreal bevacizumab to treat iris neovascularization and neovascular glaucoma secondary to ischemic retinal diseases in 41 consecutive cases.2008

    • Author(s)
      Wakabayashi T, Oshima Y, Sakaguchi H, Ikuno Y, Miki A, Gomi F, Otori Y, Kamei M, Kusaka S, Tano Y.
    • Journal Title

      Ophthalmology. 115(9)

      Pages: 1571-1580

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intravitreal injection of bevacizumab for choroidalneovascularization caused bypathological myopia2007

    • Author(s)
      Sakaguchi H, Ikuno Y, Gomi F, Kamei M, Sawa M, Tsujikawa M, Oshima Y, Kusaka S,Tano Y
    • Journal Title

      Br J Ophthalmol 91

      Pages: 161-5

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Scavenger Receptors for Oxidized Lipoprotein in Age-related MacularDegeneration2007

    • Author(s)
      Kamei M, Yoneda K, Kume N, Suzuki M, Itabe H, Matsuda K, Shimaoka T, et. al.
    • Journal Title

      Invest Ophthalmol Vis Sci 48

      Pages: 1801-1807

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxidized Phospholipids in the Macula Increasedwith Age and in Eyes with Age-relatedMacular Degeneration2007

    • Author(s)
      Suzuki M, Kamei M, Itabe H, Yoneda K, Bando H, Kume N, and Tano Y
    • Journal Title

      Mol Vis 13

      Pages: 772-778

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intravitreal injection of bevacizumab for choroidal neovascularization caused by pathological myopia.2007

    • Author(s)
      Sakaguchi H, Ikuno Y, Gomi F, Kamei M, Sawa M, Tsujikawa M, Oshima Y, Kusaka S, Tano Y.
    • Journal Title

      Br J Ophthalmol. 91

      Pages: 161-165

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Scavenger Receptors for Oxidized Lipoprotein in Age-related Macular Degeneration.2007

    • Author(s)
      Kamei M, Yoneda K, Kume N, Suzuki M, Itabe H, Matsuda K, Shimaoka T, Minami M, Yonehara S, Kita T and Kinoshita S
    • Journal Title

      Invest Ophthalmol Vis Sci 48

      Pages: 1801-1807

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidized Phospholipids in the Macula Increased with Age and in Eyes with Age-related Macular Degeneration.2007

    • Author(s)
      Suzuki M, Kamei M, Itabe H, Yoneda K, Bando H, Kume N, and Tano Y
    • Journal Title

      Mol Vis 13

      Pages: 772-778

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy and safety of one intravitreal injection ofbevacizumab in diabetic macular oedema.Acta Ophthalmol 2008 Jun 11

    • Author(s)
      Fang X, Sakaguchi H, Gomi F, Oshima Y, Sawa M, Tsujikawa M, Ikuno Y, Kamei M,Kusaka S, Tano Y
    • Journal Title

      [Epub ahead of print]

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] Pathogenesis of Age-related Macular Degeneration2008

    • Author(s)
      Yasuo Tano
    • Organizer
      World Ophthalmology Congress 2008
    • Place of Presentation
      Hong Kong
    • Year and Date
      2008-07-01
    • Related Report
      2008 Final Research Report
  • [Presentation] The pathogenic role of oxidized phospholipids in age-related macular degeneration2008

    • Author(s)
      Mihoko Suzuki, Motohiro Kamei. Hiroyuki Itabe, Zhao-Jiang Du, Koh-hei Sonoda, Motokazu Tsujikawal, Yasuo Tano
    • Organizer
      The association for research in Vision and Ophthalmology
    • Place of Presentation
      フォートローダデール
    • Year and Date
      2008-05-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] Motokazu Tsujikawaand Yasuo Tano. The pathogenic role of oxidizedphospholipids in age-related maculardegeneration2008

    • Author(s)
      Mihoko Suzuki, Motohiro Kamei, Hiroyuki Itabe, Zhao-Jiang Du, Koh-heiSonoda,
    • Organizer
      Association of Research for Vision and Ophthalmology 2008Annucal Meeting
    • Place of Presentation
      Fort Laudardale, FL, USA
    • Year and Date
      2008-05-01
    • Related Report
      2008 Final Research Report
  • [Presentation] 加齢黄斑変性への酸化リン脂質の関与2008

    • Author(s)
      鈴木三保子、瓶井資弘、板部洋之、Zhao-Jiang Du、辻川元一、田野保雄
    • Organizer
      日本眼科学会
    • Place of Presentation
      横浜
    • Year and Date
      2008-04-18
    • Related Report
      2008 Final Research Report
  • [Presentation] 加齢黄斑変性における酸化リン脂質の関与2008

    • Author(s)
      鈴木三保子, 瓶井資弘, 板部洋之, Zhao-Jiang Du, 辻川元一, 田野保雄
    • Organizer
      日本眼科学会
    • Place of Presentation
      東京
    • Year and Date
      2008-04-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 加齢黄斑変性における酸化リン脂質の関与2008

    • Author(s)
      瓶井資弘、鈴木三保子、板部洋之、Zhao-Jiang Du、辻川元一、田野保雄
    • Organizer
      厚生労働省科学研究研究費補助金難治性疾患克服研究事業網膜脈絡膜・視神経萎縮症に関する研究平成19年度班会議
    • Place of Presentation
      福岡
    • Year and Date
      2008-01-19
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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