Pharmacological treatment for retinopathy of prematurity using an eye drop of microcirculation dilator

• Project/Area Number: 19592021
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kobe University
• Principal Investigator: TSUKAHARA Yasutomo Kobe University, 大学院医学研究科, 准教授 (20236855)
• Co-Investigator(Kenkyū-buntansha): HONDA Shigeru 神戸大学, 医学部附属病院, 講師 (60283892) ; ISHIBASHI Kazuki 神戸大学, 医学部, 非常勤講師 (20324923)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 未熟児網膜症 / 動物モデル / α1受容体阻害薬 / 点眼治療 / 塩酸ブナゾシン / マウス血管新生モデル / α1レセプター / 神経節細胞 / 微小循環改善薬 / マウスモデル / マイクロアレイ

Research Abstract

高酸素負荷によって誘導した血管新生網膜症モデルマウスにおいて、α1受容体阻害薬である塩酸ブナゾシンを点眼することによって網膜虚血の改善と血管新生の抑制を行うことができた。組織学的検討からはα1受容体が網膜血管ではなく、神経節細胞に分布していることが明らかになり、塩酸ブナゾシンが血管拡張を通して作用したのではなく、何らかの抗α1作用を介して無血管野の減少に貢献したことが示唆された。

Research Products

• [Journal Article] Expression of ATP-binding cassette transporters at the inner blood-retinal barrier in a neonatal mouse model of oxygen induced retinopathy (2009)
  • Author(s): Tagami M, Kusuhara S, Honda S, Tsukahara Y, Negi A.
  • Journal Title: Brain Res. (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Anti-angiogenic effects of non-peptide integrin alphavbeta3 specific antagonist on laser-induced choroidal neovascularization in mice. (2009)
  • Author(s): Honda s, et al
  • Journal Title: Graefes Arch Clin Exp Ophthalmol. 247 Pages: 515-522
  • Peer Reviewed
• [Journal Article] Acute contraction of the proliferative membrane after an intravitreal injection of bevacizumab for advanced retinopathy of prematurity (2008)
  • Author(s): Honda S, Hirabayashi H, Tsukahara Y, Negi A.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol 246 Pages: 1061-1063
  • Peer Reviewed
• [Journal Article] Rapid regression of retinal hemorrhage and neovascularization in a case of familial exudative vitreoretinopathy treated with intravitreal bevacizumab. (2008)
  • Author(s): Tagarni M, et al
  • Journal Title: Graefes Arch Clin Exp Ophthalmol. 246 Pages: 1787-1789
  • Peer Reviewed
• [Journal Article] Acute contraction of the proliferative membrane after an intravitreal injection of bevacizumab for advanced retinopathy of prematurity. (2008)
  • Author(s): Honda s, et al
  • Journal Title: Graefes Arch Clin Exp Ophtlialmol. 246 Pages: 1061-1063
  • Peer Reviewed
• [Journal Article] Anti-angiogenic effects of bisphosphonates on laser-induced choroidal neovascularization in mice. (2007)
  • Author(s): Nagai T, et. al.
  • Journal Title: Invest Ophthalmol Vis Sci 48 Pages: 5716-5721
  • Peer Reviewed
• [Journal Article] The up-regulation of angiogenic gene expressions in cultured retinal pigmentepithelial cells grown on collagen type 1. (2007)
  • Author(s): Imai H, et. al.
  • Journal Title: Curr Eye Res 32 Pages: 903-910
  • Peer Reviewed
• [Journal Article] Autologous plasmin-assisted vitrectomy for stage 5 retinopathy of prematurity: a preliminary trial. (2007)
  • Author(s): Tsukahara Y, Et. al.
  • Journal Title: Am J Ophthalmol 144 Pages: 139-141
  • Peer Reviewed
• [Presentation] 母体喫煙の重症未熟児網膜症進展に対する抑止効果について (2008)
  • Author(s): 田上瑞記, 平林宏章, 本田茂, 森岡一朗, 横山直樹, 松尾雅文, 根木昭
  • Organizer: 第62回日本臨床眼科学会
  • Place of Presentation: 東京