The role of sunlight exposure, humoral factors, and arteriosclerosis in age-related macular degeneration

• Project/Area Number: 19592028
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kagoshima University
• Principal Investigator: OKUBO Akiko Kagoshima University, 医学部・歯学部附属病院, 講師 (60295251)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 脈絡膜血管 / 加齢黄斑変性 / 紫外線

Research Abstract

加齢黄斑変性は、高齢者の黄斑部に脈絡膜新生血管を生じる疾患で、本邦でも中途失明原因の上位を占めている。加齢黄斑変性に紫外線の影響があるかを調べるため、生涯に紫外線に曝露される量を顔面皮膚の皺量として定量化し、関連を評価したところ、少なくとも鹿児島県では紫外線曝露と加齢黄斑変性は関連があるかもしれないというデータが得られた。また、加齢黄斑変性のひとつのタイプであるポリープ状脈絡膜血管症の発症には脈絡膜の血管構築が関与している知見が得られた。さらに、この疾患の中には自然経過が良好な症例もあり、初診時の眼底所見と最初の2年間の視力経過が予後を予測する因子である可能性を見出した。また、網膜疾患と液性因子については、High Mobility Group Box Protein 1が、眼内の創傷治癒を誘導する網膜色素上皮の遊走に働く重要な伝達物質である可能性を見出した。

Research Products

• [Journal Article] Nasal and independent polypoidal lesions in polypoidal choroidal vasculopathy. (2009)
  • Author(s): Okubo A, et al.
  • Journal Title: Graefe's Arch Clin Exp Ophthalmol 247 Pages: 421-5
  • Peer Reviewed
• [Journal Article] Intraocular expression and release of high-mobility group box 1 protein in retinal detachment. (2009)
  • Author(s): Arimura N, Ki-Y, Hashiguchi T, Kawahara K, Biswas KK, Nakamura M, Sonoda Y, Yamakiri K, Okubo A, Sakamoto T, Maruyama I.
  • Journal Title: Lab Invest 89 Pages: 278-89
  • Peer Reviewed
• [Journal Article] Nasal and independent polypoidal lesions in polypoidal choroidal vasculopathy. (2009)
  • Author(s): Okubo A, et al.
  • Journal Title: Graefe's Arch Clin Exp Ophthalmol 247(3) Pages: 421-425
  • Peer Reviewed
• [Journal Article] Intraocular expression and release of high-mobility group box 1protein in retinal detachment. (2009)
  • Author(s): Arimura N, et al.
  • Journal Title: Lab Invest 89(3) Pages: 278-289
  • Peer Reviewed
• [Journal Article] Clinical features of early and late stage polypoidal choroidal vasculopathy characterized by lesion size and disease duration. (2008)
  • Author(s): Okubo A, et al.
  • Journal Title: Graefe's Arch Clin Exp Ophthalmol 246 Pages: 491-9
  • Peer Reviewed
• [Journal Article] Age-related maculopathy and sunlight exposure evaluated by objective measurement. (2008)
  • Author(s): Hirakawa M. Tanaka M, Tanaka Y, Okubo A, Koriyama C, Tsuji M, Akiba S, Miyamoto K, Hillebrand G, Yamashita T, Sakamoto T. et al
  • Journal Title: Br J Ophthalmol 92 Pages: 630-4
  • Peer Reviewed
• [Journal Article] Clinical features of early and late stage polypoidal choroidal vasculopathy characterized by lesion size and disease duration. (2008)
  • Author(s): Okubo A, et al.
  • Journal Title: Graefe's Arch Clin Exp Ophthalmol 246(4) Pages: 491-499
  • Peer Reviewed
• [Journal Article] Age-related maculopathy and sunlight exposure evaluated by objective measurement. (2008)
  • Author(s): Hirakawa M, et al.
  • Journal Title: Br J Ophthalmol 92(5) Pages: 630-634
  • Peer Reviewed
• [Journal Article] 眼底画像所見を読み解く II. 加齢黄斑変性 3. ポリープ状脈絡膜血管症 (2008)
  • Author(s): 大久保明子
  • Journal Title: 眼科診療プラクティス 21 Pages: 186-187
  • Peer Reviewed
• [Journal Article] Clinical features of early and late stage polypoidal choroidal vasculopathy characterized by lesion size and disease duration (2008)
  • Author(s): Okubo A, et. al.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol (in press)
  • Peer Reviewed
• [Journal Article] Age・related maculopathy and sunlight exposure evaluated by objective measurement (2008)
  • Author(s): Hirakawa M, et. al.
  • Journal Title: Br J Ophthalmol (in press)
  • Peer Reviewed
• [Journal Article] 網膜硝子体の診療の進歩 : 治療手技の進歩.加齢黄斑変性.ポリープ状脈絡膜血管症 (2007)
  • Author(s): 大久保明子
  • Journal Title: あたらしい眼科 24 Pages: 118-123
• [Journal Article] 網膜硝子体の診療の進歩:治療手技の進歩.加齢黄斑変性.ポリープ状脈絡膜血管症 (2007)
  • Author(s): 大久保明子
  • Journal Title: あたらしい眼科 24 Pages: 118-123
• [Presentation] ポリープ状脈絡膜血管症の長期自然経過 (2008)
  • Author(s): 大久保明子他
  • Organizer: 第47回日本網膜硝子体学会総会・第25回日本眼循環学会合同学会
  • Place of Presentation: 京都
  • Year and Date: 2008-11-29
• [Presentation] Nasal and independent lesions in polypoidal choroidal vasculopathy. (2008)
  • Author(s): Okubo A, et al.
  • Organizer: The first joint meeting of Korea-China-Japan Ophthalmologists.
  • Place of Presentation: Seoul
  • Year and Date: 2008-11-01
• [Presentation] Benign natural course of a patient with polypoidal choroidal vasculopathy observed over a five-year period. (2008)
  • Author(s): Okubo A, et al.
  • Organizer: World Congress of Ophthalmology
  • Place of Presentation: 香港
  • Year and Date: 2008-06-28
• [Presentation] ポリープ状脈絡膜血管症の病理と病態 (シンポジウム) (2007)
  • Author(s): 大久保明子
  • Organizer: 第24回日本眼循環学会
  • Place of Presentation: 香川
  • Year and Date: 2007-07-14
• [Presentation] シンポジウム:ポリープ状脈絡膜血管症の病理と病態 (2007)
  • Author(s): 大久保明子
  • Organizer: 第24回日本眼循環学会
  • Place of Presentation: 香川
  • Year and Date: 2007-07-14
• [Presentation] Early indications of polypoidal choroidal vasculopathy Early indications of polypoidal choroidal vasculopathy. (2007)
  • Author(s): Okubo A, et al.
  • Organizer: ARVO
  • Place of Presentation: Fort Lauderdale, USA
  • Year and Date: 2007-05-07
• [Presentation] Early indications of polypoidal choroidal vasculopathy (2007)
  • Author(s): Okubo A, et. al.
  • Organizer: The association for research in vision and ophthalmology
  • Place of Presentation: Fort Lauderdale, USA
  • Year and Date: 2007-05-07
• [Presentation] 初期のポリープ状脈絡膜血管症の特徴 (2007)
  • Author(s): 大久保明子他
  • Organizer: 第111回日本眼科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-19
• [Book] 眼底画像所見を読み解く(田野保雄他編)II.加齢黄斑変性 3.ポリープ状脈絡膜血管症眼科診療プラクティス21 (2008)
  • Author(s): 大久保明子
  • Publisher: 文光堂
• [Book] 眼科プラクティス21巻 眼底画像所見を読み解く (2008)
  • Author(s): 大久保明子(田野保雄ら編)
  • Publisher: 文光堂(印刷中)
• [Book] 黄斑部の網膜剥離と網膜色素上皮剥離. 眼科検査のグノーティ・セアウトン
  • Author(s): 大久保明子
  • Publisher: シナジー出版(印刷中)