Expression of thymidine phosphorylase in intraocular neovascularization

• Project/Area Number: 19592029
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Fukushima Medical University
• Principal Investigator: IIDA Tomohiro Fukushima Medical University, 医学部, 教授 (50241881)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 増殖糖尿病網膜症 / チミジンホスホリラーゼ / 血管新生 / 免疫組織化学染色 / 網膜 / 血管新生色 / 免疫組織化学染

Research Abstract

チミジンホスホリラーゼ(TP)の活性は正常組織に比べて癌組織中で亢進する。本研究では増殖糖尿病網膜症における増殖組織中でのTPの発現について、硝子体手術の際に摘出された増殖膜を用いてTPを免疫組織化学的に検討し、臨床所見との関連を検索した。その結果、TPは活動性の高い症例の増殖膜で発現しており、増殖糖尿病網膜症の血管新生に関わっている可能性が示された。

Research Products

• [Journal Article] Cytomegalovirus Retinitis After Intravitreal Triamcinolone Acetonide in an Immunocompetent (2008)
  • Author(s): Sekiryu T, Iida T, et.al.
  • Journal Title: Jpn J Ophthalmol 52 Pages: 407-425
  • Peer Reviewed
• [Journal Article] Photodynamic therapy with verteporfin for age-related macular degeneration orpolypoidal choroidal vasculopathy comparison of the presence of serous retinal pigment epithelial detachment (2008)
  • Author(s): Saito M, Iida T, et.al.
  • Journal Title: Br J Ophthalmol 92 Pages: 1642-1647
  • Peer Reviewed
• [Journal Article] Combined intravitreal bevacizumab and photodynamic therapy for retinal angiomatous proliferation (2008)
  • Author(s): Saito M, Iida T, et.al.
  • Journal Title: Am J Ophthalmol 146 Pages: 935-941
  • Peer Reviewed
• [Journal Article] Optical coherence tomography-ophthalmoscope of central serous chorioretinopathy with precipitates (2008)
  • Author(s): Kon Y, Iida T, et.al.
  • Journal Title: Retina 28 Pages: 864-869
  • Peer Reviewed
• [Journal Article] Manganese superoxide dismutase gene (SOD2) polymorphism and exudative age-related macular degeneration in the Japanese population (2008)
  • Author(s): Gotoh N, Iida T, et.al
  • Journal Title: Am J Ophthalmol 146
  • Peer Reviewed
• [Journal Article] The possibility of human adenovirus detection from the conjunctiva in asymptomatic cases during nosocomial infection (2008)
  • Author(s): Kaneko H, Iida T, et.al.
  • Journal Title: Cornea 27 Pages: 527-530
  • Peer Reviewed
• [Journal Article] Cross-sectional and en face optical coherence tomographic features of polypoidal choroidal vasculopathy (2008)
  • Author(s): Saito M, Iida T, et.al.
  • Journal Title: Retina 28 Pages: 459-464
  • Peer Reviewed
• [Journal Article] Choroidal circulatory disturbances associated with retinal angiomatous proliferation on indocyanine green angiography (2008)
  • Author(s): Koizumi H, Iida T, et.al.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol 246 Pages: 515-520
  • Peer Reviewed
• [Journal Article] Resolution of retinoschisis after vitreous surgery inX-linked retinoschisis (2008)
  • Author(s): Ikeda F, Iida T, et.al.
  • Journal Title: Ophthalmology 115 Pages: 718-722
  • Peer Reviewed
• [Journal Article] Comparative therapy evaluation of intravitreal bevacizumab and triamcinolone acetonide on persistent diffuse diabetic macular edema (2008)
  • Author(s): Shimura M, Iida T, et.al.
  • Journal Title: Am J Ophthalmol 145 Pages: 854-861
  • Peer Reviewed
• [Journal Article] Sodium hyaluronate eye drops prevent late-onset bleb leakage after trabeculectomy with mitomycin C (2008)
  • Author(s): Sagara H, Iida T, et.al.
  • Journal Title: Eye 22 Pages: 507-514
  • Peer Reviewed
• [Journal Article] Indocyanine green angiography in eyes with substantially increased subretinal fluid 1 week after photodynamic therapy (2008)
  • Author(s): Koizumi H, Iida T, et.al.
  • Journal Title: Retinal Cases & Brief Reports 2 Pages: 12-14
  • Peer Reviewed
• [Journal Article] 増殖糖尿病網膜症に至ったPrader-Willi症候群の2例 (2008)
  • Author(s): 板垣可奈子, 飯田知弘, 他
  • Journal Title: あたらしい眼科 25 Pages: 409-412
  • NAID: 10022617501
  • Peer Reviewed
• [Journal Article] Cytomegalovirus Retinitis After Intravitreal Triamcinolone Acetonide in an Immunocompetent. (2008)
  • Author(s): Sekiryu T, Iida T, et al.
  • Journal Title: Jpn J Ophthalmol 52 Pages: 407-425
  • Peer Reviewed
• [Journal Article] Photodynamic therapy with verteporfin for age-related macular degeneration or polypoidal choroidal vasculopathy : comparison of the presence of serous retinal pigment epithelial detachment. (2008)
  • Author(s): Saito M, Iida T, et al.
  • Journal Title: Br J Ophthalmol 92 Pages: 1642-1647
  • Peer Reviewed
• [Journal Article] Combined intravitreal bevacizumab and photodynamic therapy for retinal angiomatous proliferation. (2008)
  • Author(s): Saito M, Iida T, et al.
  • Journal Title: Am J Ophthalmol 146 Pages: 935-941
  • Peer Reviewed
• [Journal Article] Optical coherence tomography-ophthalmoscope of central serous chorioretinopathy with precipitates. (2008)
  • Author(s): Kon Y, Iida T, et al.
  • Journal Title: Retina 28 Pages: 864-869
  • Peer Reviewed
• [Journal Article] Manganese superoxide dismutase gene (S0D2) polymorphism and exudative age-related macular degeneration in the Japanese population. (2008)
  • Author(s): Gotoh N, Iida T, et al.
  • Journal Title: Am J Ophthalmol 146 Pages: 146-146
  • Peer Reviewed
• [Journal Article] The possibility of human adenovirus detection from the conjunctiva in asymptomatic cases during nosocomial infection. (2008)
  • Author(s): Kaneko H, Iida T, et al.
  • Journal Title: Cornea 27 Pages: 527-530
  • Peer Reviewed
• [Journal Article] Cross-sectional and en face optical coherence tomographic features of polypoidal choroidal vasculopathy. (2008)
  • Author(s): Saito M, Iida T, et al.
  • Journal Title: Retina 28 Pages: 459-464
  • Peer Reviewed
• [Journal Article] Choroidal circulatory disturbances associated with retinal angiomatous proliferation on indocyanine green angiography. (2008)
  • Author(s): Koizumi H, Iida T, et al.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol 246 Pages: 515-520
  • Peer Reviewed
• [Journal Article] Resolution of retinoschisis after vitreous surgery in X-linked retinoschisis. (2008)
  • Author(s): Ikeda F, Iida T, et al.
  • Journal Title: Ophthalmology 115 Pages: 718-722
  • Peer Reviewed
• [Journal Article] Comparative therapy evaluation of intravitreal bevacizumab and triamcinolone acetonide on persistent diffuse diabetic macular edema. (2008)
  • Author(s): Shimura M, Iida T, et al.
  • Journal Title: Am J Ophthalmol 145 Pages: 854-861
  • Peer Reviewed
• [Journal Article] Sodium hyaluronate eye drops prevent late-onset bleb leakage after trabeculectomy with mitomycin C. (2008)
  • Author(s): Sagara H, Iida T, et al.
  • Journal Title: Eye 22 Pages: 507-514
  • Peer Reviewed
• [Journal Article] Indocyanine green angiography in eyes with substantially increased subretinal fluid 1 week after photodynamic therapy. (2008)
  • Author(s): Koizumi H, Iida T, et al.
  • Journal Title: Retinal Cases & Brief Reports 2 Pages: 12-14
  • Peer Reviewed
• [Journal Article] Long-term observation of fundus infrared fluorescence after indocyanine green-assisted vitrectomy (2007)
  • Author(s): Sekiryu T, Iida T.
  • Journal Title: Retina 27 Pages: 190-197
  • Peer Reviewed
• [Journal Article] Clinical characteristics of exudative age-related macular degeneration in Japanese patients (2007)
  • Author(s): Maruko I, Iida T, et.al.
  • Journal Title: Am J Ophthalmol 144 Pages: 15-22
  • Peer Reviewed
• [Journal Article] Recurrence after surgical ablation for retinal angiomatous proliferation (2007)
  • Author(s): Shiragami C, Iida T, et.al.
  • Journal Title: Retina 27 Pages: 198-203
  • Peer Reviewed
• [Journal Article] Lobular structure of choriocapillaris in a patient with ophthalmic artery occlusion (2007)
  • Author(s): Fujiwara T, Iida T, et.al.
  • Journal Title: Jpn J Ophthalmol 51 Pages: 478-480
  • NAID: 10020179212
  • Peer Reviewed
• [Journal Article] Crystal-storing histiocytosis associated with MALT lymphoma of the ocular adnexa : a case report with review of literature (2007)
  • Author(s): Kusakabe T, Iida T, et.al.
  • Journal Title: Virchows Arch 450 Pages: 103-108
  • Peer Reviewed
• [Journal Article] Polypoidal choroidal vasculopathy with an appearance similar to classic choroidal neovascularisation on fluorescein angiography (2007)
  • Author(s): Iida T.(Editorials)
  • Journal Title: Br J Ophthalmol 91 Pages: 1103-1104
  • Peer Reviewed
• [Journal Article] Combined triamcinolone acetonide injection and grid laser photocoagulation : a promising treatment for diffuse diabetic macular edema (2007)
  • Author(s): Iida T.(Editorials)
  • Journal Title: Br J Ophthalmol 91 Pages: 407-408
  • Peer Reviewed
• [Journal Article] Chnical characteristics of exudative age-related macular degeneration in Japanese patients. (2007)
  • Author(s): Iida T, et. al.
  • Journal Title: Am J Ophthalmol 144 Pages: 15-22
  • Peer Reviewed
• [Journal Article] Long-term observation of fundus infrazed fluorescence after indocyanine green-assisted vitrectomy. (2007)
  • Author(s): Iida T, et. al.
  • Journal Title: Retina 27 Pages: 190-197
  • Peer Reviewed
• [Journal Article] Recurrence after surgical ablation for retinal angiomatous proliferation. (2007)
  • Author(s): Iida T, et. al.
  • Journal Title: Retina 27 Pages: 198-203
  • Peer Reviewed
• [Journal Article] Lobular structure of choriocapillaris in a patient with ophthalmic artery occlusion. (2007)
  • Author(s): Iida T, et. al.
  • Journal Title: Jpn J Ophthalmol 51 Pages: 478-480
  • NAID: 10020179212
  • Peer Reviewed
• [Journal Article] Crystal-storing histiocytosis associated with MALT lymphoma of the ocular adnexa: a case report with review of literature. (2007)
  • Author(s): Iida T, et. al.
  • Journal Title: Virchows Arch 450 Pages: 103-108
  • Peer Reviewed
• [Presentation] HRA2 and Spectral Doman OCT for Diagnosis and Management of MacularDisease (2008)
  • Author(s): Iida T.
  • Organizer: AAO
  • Place of Presentation: USA
  • Year and Date: 2008-11-08
• [Presentation] HRA2 and Spectral Doman OCT for Diagnosis and Management of Macular Disease. (2008)
  • Author(s): Iida T
  • Organizer: AAO
  • Place of Presentation: USA
  • Year and Date: 2008-11-08
• [Presentation] Combined Cases of Polypoidal Choroidal Vasculopathy and Typical Age-Related Macular Degeneration (2008)
  • Author(s): Maruko I, Iida T, Saito M, Nagayama D, SaitoK
  • Organizer: World Ophthalmology Congress 2008
  • Place of Presentation: HONG KONG
• [Presentation] Combined Intravitreal Bevacizumab and Photodynamic Therapy for Retinal Angiomatous Proliferation (2008)
  • Author(s): Saito M, Shiragami C, Nagayama D, Iida T, Shiraga F.
  • Organizer: ARVO 2008 ANNUAL MEETING
  • Place of Presentation: USA
• [Presentation] Autofluorescence Densitometry Using Scanning Laser Ophthalmoscope (2008)
  • Author(s): Sekiryu T, Iida T, Maruko,I, Saito M, Kondo T
  • Organizer: ARVO 2008 ANNUAL MEETING
  • Place of Presentation: USA
• [Presentation] Combined cases of polypoidal choroidal vasculopathy and typical age-related macular degeneration (2008)
  • Author(s): Iida T.
  • Organizer: The Macula Society 31^<th> Annual Meeting
  • Place of Presentation: USA
• [Presentation] Combined Intravitreal Bevacizumab and Photodynamic Therapy for Retinal Angiomatous Proliferation. (2008)
  • Author(s): Saito M, Shiragami C, Nagayama D, Iida T, Shiraga F.
  • Organizer: ARVO 2008 ANNUAL MEETING
  • Place of Presentation: USA
• [Presentation] Autofluorescence Densitometry Using Scanning Laser Ophthalmoscope. (2008)
  • Author(s): Sekiryu T, Iida T Maruko, I, Saito M, Kondo T.
  • Organizer: ARVO 2008 ANNUAL MEETING
  • Place of Presentation: USA
• [Presentation] Combined Cases of Polypoidal Choroidal Vasculopathy and Typical Age-Related Macular Degeneration. (2008)
  • Author(s): Maruko I, Iida T, Saito M, Nagayama D, SaitoK.
  • Organizer: World Ophthalmology Congress2008
  • Place of Presentation: HONG KONG.
• [Presentation] Early Morphologic Changes in Group 2A Idiopathic Juxtafoveolar Retinal Telangiectasis Using Fourier Domain Optical Coherence Tomography (2007)
  • Author(s): Iida T, Maruko I, Sekiryu T, Fujiwara T
  • Organizer: The Macula Society 30^<th> Annual Meeting
  • Place of Presentation: London
• [Presentation] Optical Coherence Tomography in Patients with Macular Edema resolution after Treatmant for Branch Retinal Vein Occlusion (2007)
  • Author(s): Sekiryu T, Maruko I, Iida T, Saito M
  • Organizer: ARVO 2007 ANNUAL MEETING
  • Place of Presentation: USA
• [Presentation] The Morphologic Changes in the Outer Layer of Detached Retina in Rhegmatogenous Retinal Detachment and Centoral Serous Chorioretinopathy (2007)
  • Author(s): Maruko I, Sekiryu T, Saito M, Saito K, Iida T
  • Organizer: ARVO 2007 ANNUAL MEETING
  • Place of Presentation: USA
• [Presentation] Optical Coherence Tomography in Patients with Macular Edema resolution after Treatmant for Branch Retinal Vein Occlusion. (2007)
  • Author(s): Sekiryu T, Maruko I, Iida T, Saito M.
  • Organizer: ARVO 2007 ANNUAL MEETING
  • Place of Presentation: USA
• [Presentation] The Morphologic Changes in the Outer Layer of Detached Retin a in Rhegmatogenous Retinal Detachment and Centoral Serous Chorioretinopathy. (2007)
  • Author(s): Maruko I, Sekiryu T, Saito M, Saito K, Iida T.
  • Organizer: ARVO 2007 ANNUAL MEETING
  • Place of Presentation: USA
• [Presentation] Early Morphologic Changes in Group 2A Idiopathic Juxtafoveolar Retinal Telangiectasis Using Fourier Domain Optical Coherence Tomography (2007)
  • Author(s): Iida T, Maruko I, Sekiryu T, Fujiwara T.
  • Organizer: The Macula Society 30th Annual Meeting
  • Place of Presentation: London
• [Book] macular telangiectasia黄斑部毛細血管拡張症・浮腫を生かすためには : 光凝固~薬物療法(白神史雄(編)眼科インストラクションコース15ここまできた!網膜疾患治療) (2008)
  • Author(s): 丸子一朗, 飯田知弘
  • Publisher: メディカルビュー社, 東京
• [Book] 特発性黄斑部毛細血管拡張症(田野保雄(編)眼科プラクティス21眼底画像所見を読み解く) (2008)
  • Author(s): 丸子一朗, 飯田知弘
  • Publisher: 文光堂, 東京
• [Book] 眼科インストラクションコース15 ここまできた! 網膜疾患治療 (2008)
  • Author(s): 丸子一朗, 飯田知弘, et al.
  • Publisher: メデイカルビュー社
• [Book] 眼科プラクティス21眼底画像所見を読み解く (2008)
  • Author(s): 丸子一朗, 飯田知弘, et al.
  • Publisher: 文光堂
• [Book] 網膜静脈閉塞症(臼井正彦, 他(編), 眼科診療便利手帖改訂第2版) (2007)
  • Author(s): 飯田知弘
  • Total Pages: 134
  • Publisher: 診断と治療社, 東京
• [Book] 網膜動脈閉塞症(臼井正彦, 他(編), 眼科診療便利手帖改訂第2版) (2007)
  • Author(s): 飯田知弘
  • Total Pages: 132
  • Publisher: 診断と治療社, 東京
• [Book] 加齢黄斑変性(山口徹, 他(編), 今日の治療指針2007) (2007)
  • Author(s): 飯田知弘
  • Total Pages: 1027
  • Publisher: 医学書院, 東京
• [Book] ドルーゼン(硬・軟・家族性)(田野保雄, 他(編), 今日の眼疾患治療指針第2版) (2007)
  • Author(s): 飯田知弘
  • Publisher: 医学書院, 東京
• [Book] 中心性漿液性脈絡網膜症(田野保雄, 他(編), 今日の眼疾患治療指針第2版) (2007)
  • Author(s): 飯田知弘
  • Publisher: 医学書院, 東京
• [Book] 高血圧性眼底変化(田野保雄, 他(編), 今日の眼疾患治療指針第2版) (2007)
  • Author(s): 飯田知弘
  • Publisher: 医学書院, 東京
• [Book] 網膜静脈閉塞症(田野保雄, 他(編), 今日の眼疾患治療指針第2版) (2007)
  • Author(s): 飯田知弘
  • Publisher: 医学書院, 東京
• [Book] 加齢黄斑変性(田野保雄, 他(編), 今日の眼疾患治療指針第2版) (2007)
  • Author(s): 飯田知弘
  • Publisher: 医学書院, 東京
• [Book] Perimetry and the Fundus (2007)
  • Author(s): Sagara H, Suzuki K,Iida T. et.al.
  • Publisher: An introduction to microperimetry SLACK Incorporated, Thorofare
• [Book] Perimetry and the Fundus. An introduction to microperimetry. (2007)
  • Author(s): Sagara H, Suzuki K, Iida T
  • Publisher: SLACK Incorporated, Thorofare