• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Functional analysis of costimulatory molecules in autoimmune uveitis and their intervention for clinical application

Research Project

Project/Area Number 19592040
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionJuntendo University

Principal Investigator

AKIBA Hisaya  Juntendo University, 医学部, 准教授 (60338316)

Co-Investigator(Kenkyū-buntansha) USUI Yoshihiko  東京医科大学, 医学部, 助教 (50408142)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsT細胞分化・制御 / 補助シグナル分子 / 自己免疫疾患 / 喘息 / アレルギー / 実験的自己免疫性ぶどう膜網膜炎 / EAU / OX40-OX40L
Research Abstract

補助シグナル分子は、T細胞の活性化や機能に重要な役割を担っており、これらの働きを制御する抗体を開発することにより、難治性ぶどう膜網膜炎の治療が可能になるのではないかと考え、種々の補助シグナル分子に対する抗体を作製し、ぶどう膜網膜炎マウスモデルに投与して治癒効果の検討を行った。この内、T細胞分化に関わる補助シグナル分子OX40Lに対する抗体投与が、発症抑制に効果的であり、臨床応用に期待がもてる結果が得られた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (46 results)

All 2009 2008 2007 Other

All Journal Article (30 results) (of which Peer Reviewed: 30 results) Presentation (16 results)

  • [Journal Article] Suppression of experimental autoimmune uveoretinitis by regulatory dendritic cells in mice2009

    • Author(s)
      Usui, Y., M. Takeuchi, T. Hattori, Y. Okunuki, K. Nagasawa, T. Kezuka, K. Okumura, H. Yagita, H. Akiba, and H. Goto.
    • Journal Title

      Arch Ophthalmol 127

      Pages: 514-519

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] RANK-RANKL signaling pathway is critically involved in the function of CD4+ CD25+ regulatory T cells in chronic colitis2009

    • Author(s)
      Totsuka, T., T. Kanai, Y. Nemoto, T. Tomita, R. Okamoto, K. Tsuchiya, T. Nakamura, N. Sakamoto, H. Akiba, K. Okumura, H. Yagita, and M. Watanabe.
    • Journal Title

      J Immunol 182

      Pages: 6079-6087

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation2009

    • Author(s)
      Nakayama, M., H. Akiba, K. Takeda, Y. Kojima, M. Hashiguchi, M. Azuma, H. Yagita, and K. Okumura
    • Journal Title

      Blood 113

      Pages: 3821-3830

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Notch signaling confers antigen-presenting cell functions on mast cells2009

    • Author(s)
      Nakano, N., C. Nishiyama, H. Yagita, A. Koyanagi, H. Akiba, S. Chiba, H. Ogawa, and K. Okumura
    • Journal Title

      J Allergy Clin Immunol 123

      Pages: 74-81

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Notch signaling confers antigen-presenting cell functions on mast cells.2009

    • Author(s)
      Nakano N
    • Journal Title

      J Allergy Clin Immunol 123

      Pages: 74-81

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peritubular ischemia contributes more to tubular damage than proteinuria in immune-mediated glomerulonephritis2008

    • Author(s)
      Wong, M. G., Y. Suzuki, C. Tanifuji, H. Akiba, K. Okumura, T. Sugaya, T. Yamamoto, S. Horikoshi, S. Y. Tan, C. Pollock, and Y. Tomino.
    • Journal Title

      J Am Soc Nephrol 19

      Pages: 290-297

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model2008

    • Author(s)
      Ueno, T., A. Habicht, M. R. Clarkson, M. J. Albin, K. Yamaura, O. Boenisch, J. Popoola, Y. Wang, H. Yagita, H. Akiba, M. J. Ansari, J. Yang, L. A. Turka, D. M. Rothstein, R. F. Padera, N. Najafian, and M. H. Sayegh
    • Journal Title

      J Clin Invest 118

      Pages: 742-751

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] B7-H3 contributes to the development of pathogenic Th2 cells in a murine model of asthma2008

    • Author(s)
      Nagashima, O., N. Harada, Y. Usui, T. Yamazaki, H. Yagita, K. Okumura, K. Takahashi, and H. Akiba
    • Journal Title

      J Immunol 181

      Pages: 4062-4071

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of galectin-9 in the development of experimental allergic conjunctivitis in mice2008

    • Author(s)
      Fukushima, A., T. Sumi, K. Fukuda, N. Kumagai, T. Nishida, K. Okumura, H. Akiba, H. Yagita, and H. Ueno.
    • Journal Title

      Int Arch Allergy Immunol 146

      Pages: 36-43

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel ICOS-independent, but CD28- and SAP-dependent, pathway of T cell-dependent, polysaccharide specific humoral immunity in response to intact Streptococcus pneumoniae versus pneumococcal conjugate vaccine2008

    • Author(s)
      Chen, Q., J. L. Cannons, J. C. Paton, H. Akiba, P. L. Schwartzberg, and C. M. Snapper
    • Journal Title

      J Immunol 181

      Pages: 8258-8266

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel ICOS-independent, but CD28- and SAP-dependent, pathway of T cell-dependent, polysaccharide-specific humoral immunity in response to intact Streptococcus pneumoniae versus pneumococcal conjugate vaccine.2008

    • Author(s)
      Chen Q
    • Journal Title

      J Immunol 181

      Pages: 8258-66

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] B7-H3 contributes to the development of pathogenic Th2 cells in a murine model of asthma.2008

    • Author(s)
      Nagashima O
    • Journal Title

      J Immunol 181

      Pages: 4062-71

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model.2008

    • Author(s)
      Ueno T
    • Journal Title

      J Clin Invest 118

      Pages: 742-51

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peritubular ischemia contributes more to tubular damage than proteinuria in immune-mediated glomerulonephritis.2008

    • Author(s)
      Wong MG
    • Journal Title

      J Am Soc Nephrol 19

      Pages: 290-7

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of galectin-9 in the development of experimental allergic conjunctivitis in mice.2008

    • Author(s)
      Fukushima A
    • Journal Title

      Int Arch Allergy Immunol 146

      Pages: 36-43

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model2008

    • Author(s)
      Ueno T
    • Journal Title

      J Clin Invest 118

      Pages: 742-751

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peritubular ischemia contributes more to tubular damage than proteinuria in immune-mediated glomerulonephritis2008

    • Author(s)
      Wong MG
    • Journal Title

      J Am Soc Nephrol 19

      Pages: 290-297

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function2007

    • Author(s)
      Xiao, S., N. Najafian, J. Reddy, M. Albin, C. Zhu, E. Jensen, J. Imitola, T. Korn, A. C. Anderson, Z. Zhang, C. Gutierrez, T. Moll, R. A. Sobel, D. T. Umetsu, H. Yagita, H. Akiba, T. Strom, M. H. Sayegh, R. H. DeKruyff, S. J. Khoury, and V. K. Kuchroo
    • Journal Title

      J Exp Med 204

      Pages: 1691-1702

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells2007

    • Author(s)
      Nakae, S., M. Iikura, H. Suto, H. Akiba, D. T. Umetsu, R. H. Dekruyff, H. Saito, and S. J. Galli
    • Journal Title

      Blood 110

      Pages: 2565-2568

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of the OX40 ligand prolongs corneal allograft survival2007

    • Author(s)
      Hattori, T., Y. Usui, Y. Okunuki, Y. Sonoda, M. Usui, E. Takada, J. Mizuguchi, H. Yagita, K. Okumura, H. Akiba, and M. Takeuchi
    • Journal Title

      Eur J Immunol 37

      Pages: 3597-3604

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] B7-H3 regulates the development of experimental allergic conjunctivitis in mice2007

    • Author(s)
      Fukushima, A., T. Sumi, K. Fukuda, N. Kumagai, T. Nishida, T. Yamazaki, H. Akiba, K. Okumura, H. Yagita, and H. Ueno
    • Journal Title

      Immunol Lett 113

      Pages: 52-57

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] T-cell Ig and mucin domain-containing protein (Tim)-2 regulates murine allergic conjunctivitis during the effector phase2007

    • Author(s)
      Fukushima, A., T. Sumi, K. Fukuda, N. Kumagai, T. Nishida, K. Okumura, H. Akiba, H. Yagita, and H. Ueno
    • Journal Title

      Immunol Lett 110

      Pages: 133-138

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antibodies to T-cell Ig and mucin domain-containing proteins (Tim)-1 and -3 suppress the induction and progression of murine allergic conjunctivitis2007

    • Author(s)
      Fukushima, A., T. Sumi, K. Fukuda, N. Kumagai, T. Nishida, H. Akiba, K. Okumura, H. Yagita, and H. Ueno
    • Journal Title

      Biochem Biophys Res Commun 353

      Pages: 211-216

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of Galectin-9 in the Development of Experimental Allergic Conjunctivitis in Mice2007

    • Author(s)
      Fukushima A
    • Journal Title

      Int Arch Allergy Immunol 146

      Pages: 36-43

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of the OX40 ligand prolongs corneal allograft survival2007

    • Author(s)
      Hattori T
    • Journal Title

      Eur J Immunol 37

      Pages: 3597-3604

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] B7-H3 regulates the development of experimental allergic conjunctivitis in mice2007

    • Author(s)
      Fukushima A
    • Journal Title

      Immunol Lett 113

      Pages: 52-57

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells2007

    • Author(s)
      Nakae S
    • Journal Title

      Blood 110

      Pages: 2565-2568

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function2007

    • Author(s)
      Xiao S
    • Journal Title

      J Exp Med 204

      Pages: 1691-1702

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] T-cell Ig and mucin domain-containing protein(Tim)-2 regulates murine allergic conjunctivitis during the effector phase2007

    • Author(s)
      Fukushima A
    • Journal Title

      Immunol Lett 110

      Pages: 133-138

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibodies to T-cell Ig and mucin domain-containing proteins(Tim)-1and-3suppress the induction and progression of murine allergic conjunctivitis2007

    • Author(s)
      Fukushima A
    • Journal Title

      Biochem Biophys Res Commun 353

      Pages: 211-216

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] TIM-3 mediates phagocytosis of apoptotic cells by inflammatory macrophage and CD8 dendritic cell subsets2008

    • Author(s)
      Nakayama M.
    • Organizer
      日本免疫学会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2008-12-03
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] The role of TIM-2 in regulation of collagen-induced arthritis2008

    • Author(s)
      Kawamoto T.
    • Organizer
      日本免疫学会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2008-12-02
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Roles of PD-1/PD-1 ligands pathway in the development of murine experimental autoimmune uveoretinitis2008

    • Author(s)
      Usui Y.
    • Organizer
      日本免疫学会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2008-12-01
    • Related Report
      2008 Final Research Report
  • [Presentation] Roles of PD-l/PD-1 ligands pathway in the development of murine experimenta1 autoimmune uveoretinitis.2008

    • Author(s)
      Usui Y
    • Organizer
      日本免疫学会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2008-12-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] The role of PD-1/PD-L pathway in regulation of murine experimental autoimmune uveoretinitis (EAU).2008

    • Author(s)
      Usui Y
    • Organizer
      The Association for Reseach in Vision and Ophthalmology, Annual Meeting 2008
    • Place of Presentation
      Fort Lauderdale, FL
    • Year and Date
      2008-04-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Functional expression of CD40 in corneal neovasculization2008

    • Author(s)
      Hattori T.
    • Organizer
      The Association for Reseach in Vision and Ophthalmology, Annual Meeting
    • Place of Presentation
      Fort Lauderdale, FL
    • Year and Date
      2008-04-28
    • Related Report
      2008 Final Research Report
  • [Presentation] Functional expression of CD40 in corneal neovasculization.2008

    • Author(s)
      Hattori T
    • Organizer
      The Association for Reseach in Vision and Ophthalmology, Annual Meeting 2008
    • Place of Presentation
      Fort Lauderdale, FL
    • Year and Date
      2008-04-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Notch signaling induces MHC class II expression on mast cell surface2007

    • Author(s)
      Nakano Nobuhiro
    • Organizer
      第37回日本免疫学会
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Year and Date
      2007-11-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] TIM-1 signaling in B cells regulates antibody production2007

    • Author(s)
      Akiba H.
    • Organizer
      日本免疫学会
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Year and Date
      2007-11-20
    • Related Report
      2008 Final Research Report
  • [Presentation] B7-H3 regulates asthmatic response in a murine model of asthma2007

    • Author(s)
      Nagashima O.
    • Organizer
      日本免疫学会
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Year and Date
      2007-11-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Notch signaling induces MHC class II expression on mast cell surface2007

    • Author(s)
      Nakano N.
    • Organizer
      日本免疫学会
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Year and Date
      2007-11-20
    • Related Report
      2008 Final Research Report
  • [Presentation] TIM-1 signaling in B cells regulates antibody production2007

    • Author(s)
      Akiba Hisaya
    • Organizer
      第37回日本免疫学会
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Year and Date
      2007-11-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] B7-H3 regulates asthmatic response in a murine model of asthma2007

    • Author(s)
      Nagashima Osamu
    • Organizer
      第37回日本免疫学会
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Year and Date
      2007-11-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] 実験的アレルギー性結膜疾患発症における共刺激分子Tim の関与2007

    • Author(s)
      Fukushima A.
    • Organizer
      日本眼炎症学会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2007-07-06
    • Related Report
      2008 Final Research Report
  • [Presentation] 実験的アレルギー性結膜疾患発症における共刺激分子Timの関与2007

    • Author(s)
      福島 敦樹
    • Organizer
      第41回日本眼炎症学会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2007-07-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] The role of PD-1/PD-L pathway in regulation of murine experimental autoimmune uveoretin-itis (EAU)

    • Author(s)
      Usui Y.
    • Organizer
      The Association for Reseach in Vision and Ophthalmology, Annual Meeting
    • Place of Presentation
      Fort Lauderdale, FL
    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi