Role of new co-stimulatory signaling molecules in immune responses after ocular tissue transplantation

• Project/Area Number: 19592044
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Nippon Medical School
• Principal Investigator: HORI Junko Nippon Medical School, 医学部, 准教授 (60251279)
• Co-Investigator(Kenkyū-buntansha): KITAHARA Yuki 日本医科大学, 医学部, 助教 (30360176) ; WANG Mingcong 日本医科大学, 医学系研究科, ポストドクター (90445825)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 角膜移植 / 拒絶反応 / 免疫特権 / 制御性T細胞 / GITRL / B7-H3 / 前房関連免疫偏位 / 補助刺激分子 / 移植免疫 / 免疫抑制 / 副刺激分子 / ACAID / immune privilege / GITR / GITR-L

Research Abstract

眼組織移植後の拒絶反応を自動制御する機構として、(1)眼組織に発現するGlucocorticoid-Induced TNF Receptor Ligand(GITRL)がGITRシグナルを介して眼局所に制御性T細胞(Treg)を誘導する、(2)B7-H3分子が前房関連免疫偏位を誘導する、ということを明らかにした。

Research Products

• [Journal Article] Role of B7-H1 in Immune privilege of the eye (2009)
  • Author(s): Hori J.
  • Journal Title: J Nippon Med Sch. 75. Pages: 56-57
  • Peer Reviewed
• [Journal Article] Mechanisms of immune privilege of the anterior segment---what we learn from corneal transplantation-- (2009)
  • Author(s): Hori J.
  • Journal Title: Journal of Ocular Biology Disease & Informatics 1(2) Pages: 94-100
  • Peer Reviewed
• [Journal Article] Molecular mechanisms of immune-suppressive microenvironment in the cornea (2009)
  • Author(s): Hori J.
  • Journal Title: Cornea (in press)
  • Peer Reviewed
• [Journal Article] Mechanisms of immune privilege of the anterior segment---whatwe learn from corneal transplantation (2009)
  • Author(s): Hori J
  • Journal Title: Journal of Ocular Biology Disease & Informatics 2 Pages: 94-100
  • Peer Reviewed
• [Journal Article] Latanoprost does not affect immune privilege of corneal allografts (2008)
  • Author(s): Wang MC, Kitahara Y, Yoshida A, Hori J.
  • Journal Title: Exp Eye Res 86 Pages: 394-402
  • Peer Reviewed
• [Journal Article] Role of B7-H1 in Immune privilege of the eye (2008)
  • Author(s): Hori J
  • Journal Title: J Nippon Med Sch 75 Pages: 56-57
  • Peer Reviewed
• [Journal Article] Latanoprost does not affect immune privilege of corneal allografts. (2008)
  • Author(s): Wang MC, Kitahara Y, Yoshida A, Hori J
  • Journal Title: Exp Eye Res 86 Pages: 394-402
  • Peer Reviewed
• [Journal Article] Mechanisms of immune privilege of the anterior segment-what we learn from corneal transplantation- (2008)
  • Author(s): Hori J
  • Journal Title: Journal of Ocular Biology Disease & Informatics (In press)
  • Peer Reviewed
• [Journal Article] Immune privilege and immunogenicity reside among different layers of the mouse cornea (2007)
  • Author(s): Hori J, Joyce NC, Streilein JW
  • Journal Title: Issue of OII devoted to JW Streilein, Ocul immunology & Inflammation 15 Pages: 225-240
  • Peer Reviewed
• [Journal Article] Neural progenitor cells lack immunogenicity and resist destruction as allografts (2007)
  • Author(s): Hori J, Ng TF, Shatos M, Klassen H, Streilein JW, Young MJ.
  • Journal Title: Issue of OII devoted to JW Streilein, Ocul immunology & Inflammation 15 Pages: 261-274
  • Peer Reviewed
• [Journal Article] 角膜における免疫制御とB7-H (2007)
  • Author(s): 堀純子
  • Journal Title: 臨床免疫/アレルギー科(科学評論社) 48 Pages: 325-330
  • NAID: 40015658146
• [Journal Article] 眼の免疫特権~角膜移植から学ぶ~ (2007)
  • Author(s): 堀純子
  • Journal Title: Journal of the Society of Japanese Women Scientists 8(1) Pages: 13-18
  • NAID: 130001238277
  • Peer Reviewed
• [Journal Article] Immune privilege and immunogenicity reside among different layers of the mouse cornea. (2007)
  • Author(s): HoriJ, Joyce NC, Streilein JW
  • Journal Title: Issue of OII devoted to JW Streilein, Ocul immunology & Inflammation. 15 Pages: 225-240
  • Peer Reviewed
• [Journal Article] Neural progenitor cells lack immunogenicity and resist destruction as allografts. (2007)
  • Author(s): Hori J, Ng TF, Shatos M, Klassen H, Streilein JW, Young MJ
  • Journal Title: Issue of OII devoted to JW Streilein, Oculimmunology & Inflammation 15 Pages: 261-274
  • Peer Reviewed
• [Presentation] 角膜炎症の自動制御の分子機構、シンポジウム13 : 眼免疫調節機構の不思議 (2009)
  • Author(s): 堀純子
  • Organizer: 第113回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-17
• [Presentation] GITR-L-mediated local expansion of regulatory T cell as a mechanism of immune privilege of corneal allografts. Symposium : Transplantation Immunology in the Eye. (2008)
  • Author(s): J Hori
  • Organizer: International Congress of Eye Researcn
  • Place of Presentation: 中国、北京
  • Year and Date: 2008-09-26
• [Presentation] Role of B7-H3 on immune privilege of corneal allografts (2008)
  • Author(s): H. Taniguchi, M.C. Wang, Y. Kitahara, M. Oshima, H. Yagita, J. Hori
  • Organizer: XVIII ICER (International Congress for Eye Research)
  • Place of Presentation: Beijing, China
  • Year and Date: 2008-09-24
• [Presentation] Tim-3 Is Necessary for Corneal Allograft Survival (2008)
  • Author(s): M. Tomita, M.C. Wang, H. Taniguchi, H. Takahashi, J. Shimazaki, H. Yagita, J. Hori
  • Organizer: ARVO (Association for research in vision and ophthalmology
  • Place of Presentation: Fort Lauderdale, FL, USA
  • Year and Date: 2008-05-01
• [Presentation] GITR-ligand-dependent local expansion of regulatory T cells as a mechanism of immune privilege for corneal allografts (2008)
  • Author(s): Hori J, Taniguchi H, Wang MC, Kitahara Y, Oshima M, Azuma M.
  • Organizer: Association for research in vision and ophthalmology
  • Place of Presentation: Fort Lauderdale, FL, USA
  • Year and Date: 2008-04-28
• [Presentation] B7-H3-mediated Protection Of Corneal Endothelial Cells From Killing By Allo-reactive-T Cells (2008)
  • Author(s): H. Taniguchi, M.C. Wang, Y. Kitahara, M. Oshima, H. Yagita, J. Hori
  • Organizer: ARVO(Association for research in vision and ophthalmology)
  • Place of Presentation: Fort Lauderdale, FL, USA
  • Year and Date: 2008-04-27
• [Presentation] A New Model of Anterior Scleritis Associated With Type II Collagen-Induced Arthritis (2008)
  • Author(s): M.C. Wang, H. Taniguchi, A. Nakajima, J. Hori
  • Organizer: ARVO(Association for research in vision and ophthalmology)
  • Place of Presentation: Fort Lauderdale, FL, USA
  • Year and Date: 2008-04-27
• [Presentation] 前眼部に発現するGITRLを介した制御性T細胞の誘導と眼組織障害の抑制 (2008)
  • Author(s): 堀純子、谷口ヒロコ、王明聡、高橋浩、坂口志文、東みゆき
  • Organizer: 第112回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-04-18
• [Presentation] 眼局所の免疫応答におけるB7-H3の役割 (2008)
  • Author(s): 谷口ヒロ子、堀純子、王明聡、北原由紀、大島正道、八木田秀雄
  • Organizer: 第112回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-04-18
• [Presentation] 角膜移植後の免疫応答におけるB7-H3の役割 (2008)
  • Author(s): 谷口ヒロ子、堀 純子、王 明聡、北原由紀、大島正道、八木田秀雄
  • Organizer: 第32回角膜カンファランス
  • Place of Presentation: 千葉
  • Year and Date: 2008-02-29
• [Presentation] 角膜移植の生着におけるTim-3の役割 (2008)
  • Author(s): 冨田真智子、堀 純子、王 明聡、谷口ヒロ子、高橋 浩、島崎 潤、八木田秀雄
  • Organizer: 第32回角膜カンファランス
  • Place of Presentation: 千葉
  • Year and Date: 2008-02-29
• [Presentation] GITRLを介した角膜局所における制御性T細胞の誘導 (2008)
  • Author(s): 堀 純子、谷口ヒロ子、王 明聡、高橋 浩、坂口志文、東みゆき
  • Organizer: 第32回角膜カンファランス
  • Place of Presentation: 千葉
  • Year and Date: 2008-02-28
• [Presentation] 眼局所の免疫応答におけるB7-H3の役割 (2008)
  • Author(s): 谷口ヒロ子、堀純子、王明聡、北原由紀、高橋浩、大島正道、八木田秀雄
  • Organizer: 学術展示優秀賞、第112回日本眼科学会
• [Presentation] GITR-Lingand-induced regulatory T cells as a mechanism of immune privilege of corneal allografts (2007)
  • Author(s): Hori J, Wang MC, Taniguchi H, Kitahara Y, Sakaguchi S, Azuma M.
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20
• [Presentation] Role of B7-H3 on immune privilege of corneal allografts (2007)
  • Author(s): Taniguchi H, Hori J, Wang MC, Kitahara Y, Yagita H.
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20
• [Presentation] GITR-Lingand-induced regulatory T cells as a mechanism of immune privilege of corneal allografts. (2007)
  • Author(s): Hori J, Wang MC, Taniguchi H, Kitahara Y, Sakaguchi S, Azuma M.
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20
• [Presentation] Role of B7-H3 on immune privilege of corneal allografts. (2007)
  • Author(s): Taniguchi H, Hori J, Wang MC, Kitahara Y, Yagita H.
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20
• [Presentation] 眼球結膜に多発性結節を生じたSweet病の一例 (2007)
  • Author(s): 菊池佐知子、堀 純子、塚田玲子、平岡美紀、加藤篤衛、高橋 浩
  • Organizer: 第61回日本臨床眼科学会
  • Place of Presentation: 京都
  • Year and Date: 2007-10-11
• [Presentation] 内科的治療が奏功した4歳児の急性網膜壊死の1例 (2007)
  • Author(s): 稲毛道憲、矢ロ智恵美、小野真史、堀 純子、高橋 浩、宮武千晴、菅野華子
  • Organizer: 第61回日本臨床眼科学会
  • Place of Presentation: 京都
  • Year and Date: 2007-10-11
• [Presentation] GITR-Lingand-induced regulatory T cells as a mechanism of immune privilege of corneal allografts (2007)
  • Author(s): Hori J, Taniguchi H, Wang MC, Oshima M, Azuma M, Sakaguchi S.
  • Organizer: 9^<th> international congress of IOIS
  • Place of Presentation: Paris
  • Year and Date: 2007-09-17
• [Presentation] GITR-Lingand-induced regulatory T cells as a mechanism of immune privilege of corneal allografts. (2007)
  • Author(s): Hori J, Taniguchi H, Wang MC, Oshima M, Azuma M, Sakaguchi S.
  • Organizer: 9th international congress of IOIS
  • Place of Presentation: Paris
  • Year and Date: 2007-09-17
• [Presentation] 免疫特権に関与する新規B7ファミリー分子の機能解析 (2007)
  • Author(s): 堀純子
  • Organizer: 第75回日本医科大学医学会総会、平成18年度丸山記念研究助成金受賞記念講演
  • Year and Date: 2007-09-01
• [Presentation] 免疫特権に関与する新規B7ファミリー分子の機能解析 (2007)
  • Author(s): 堀 純子
  • Organizer: 第75回日本医科大学医学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-09-01
• [Presentation] 角膜移植拒絶反応の自動制御機構、シンポジウム1 : 眼炎症. 基礎研究の最前線 (2007)
  • Author(s): 堀純子
  • Organizer: 第41回日本眼炎症学会
  • Place of Presentation: 東京
  • Year and Date: 2007-07-06
• [Presentation] 角膜移植拒絶反応の自動制御機構、シンポジウム1:眼炎症.基礎研究の最前線 (2007)
  • Author(s): 堀 純子
  • Organizer: 第41回日本眼炎症学会
  • Place of Presentation: 東京
  • Year and Date: 2007-07-06
• [Presentation] 眼組織の移植と再生における免疫学的研究 (2007)
  • Author(s): 堀純子
  • Organizer: 日本女性科学者の会第12回奨励賞受賞講演
  • Year and Date: 2007-06-16
• [Presentation] 眼組織の移植と再生における免疫学的研究 (2007)
  • Author(s): 堀 純子
  • Organizer: 日本女性科学者の会第12回奨励賞受賞講演
  • Place of Presentation: 東京
  • Year and Date: 2007-06-16
• [Presentation] Role of Glucocorticoid-Induced TNF Receptor Ligand in Immune Privilege of Corneal Allografts (2007)
  • Author(s): Hori J, Wang MC, Taniguchi H, Kitahara Y, Takahashi H, Oshima M, Sakaguchi S, Azuma M.
  • Organizer: ARVO(Association for research in vision and ophthalmology)
  • Place of Presentation: Fort Lauderdale, FL, USA
  • Year and Date: 2007-05-09
• [Presentation] Role of Glucocorticoid-Induced TNF Receptor Ligand in Immune Privilege of Corneal Allografts. (2007)
  • Author(s): Hori J, Wang MC, Taniguchi H, Kitahara Y, Takahashi H, Oshima M, Sakaguchi S, Azuma M.
  • Organizer: ARVO(Association for research in vision and ophthalmology)
  • Place of Presentation: Fort Lauderdale, FL, USA
  • Year and Date: 2007-05-09
• [Presentation] B7-H3 is necessary for corneal allograft survival (2007)
  • Author(s): Taniguchi T, Hori J, Wang MC, Kitahara Y, Takahashi H, Oshima M, Yagita H.
  • Organizer: ARVO (Association for research in vision and ophthalmology)
  • Place of Presentation: Fort Lauderdale, FL, USA
  • Year and Date: 2007-05-06
• [Presentation] B7-H3 is necessary for corneal allograft survival. (2007)
  • Author(s): Taniguchi T, Hori J, Wang MC, Kitahara Y, Takahashi H, Oshima M, Yagita H.
  • Organizer: ARVO(Association for research in vision and ophthalmology)
  • Place of Presentation: Fort Lauderdale, FL, USA
  • Year and Date: 2007-05-06
• [Presentation] C-waves in mice recorded using contact lens electrodes with integrated diodes that emit white light (2007)
  • Author(s): Kitahara Y, Hori J, Takahashi H.
  • Organizer: ARVO(Association for research in vision and ophthalmology)
  • Place of Presentation: Fort Lauderdale, FL, USA
  • Year and Date: 2007-05-06
• [Presentation] 前眼部の抗原特異的免疫応答におけるGITR - GITRL経路の役割 (2007)
  • Author(s): 堀純子、王明聡、谷口ヒロ子、北原由紀、高橋浩、大島正道、坂口志文、東みゆき
  • Organizer: 第111回日本眼科学会総
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-22
• [Presentation] 前眼部の抗原特異的免疫応答におけるB7-H3の役割 (2007)
  • Author(s): 谷口ヒロ子、堀純子、王明聡、北原由紀、高橋浩、大島正道、八木田秀雄
  • Organizer: 第111回日本眼科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-22
• [Presentation] 前眼部の抗原特異的免疫応答におけるGITR-GITRL経路の役割 (2007)
  • Author(s): 堀 純子、王 明聡、谷ロヒロ子、北原由紀、高橋 浩、大島正道、坂口志文、東みゆき
  • Organizer: 第111回日本眼科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-22
• [Presentation] サルコイドーシス診断基準の改訂による診断患者数の変化 (2007)
  • Author(s): 塚田玲子, 堀 純子, 河上花子, 平岡美紀, 高橋浩、森本泰介、工藤翔二
  • Organizer: 第111回日本眼科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-20
• [Presentation] 角膜移植拒絶反応、シンポジウム眼炎症と眼感染症への取り組み~動物モデルから学ぶこと~ (2007)
  • Author(s): 堀純子
  • Organizer: 第111回日本眼科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-19
• [Presentation] 角膜移植拒絶反応、シンポジウム眼炎症と眼感染症への取り組み〜動物モデルから学ぶこと〜 (2007)
  • Author(s): 堀 純子
  • Organizer: 第111回日本眼科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-19
• [Presentation] GITRLを介した角膜局所における制御性T細胞の誘導 (2007)
  • Author(s): 堀純子、谷口ヒロコ、王明聡、高橋浩、坂口志文、東みゆき
  • Organizer: 第32回角膜カンファランス
  • Place of Presentation: 千葉
  • Year and Date: 2007-02-28
• [Presentation] 角膜移植の生着におけるB7-H3の役割 (2007)
  • Author(s): 北原由紀、堀 純子、王 明聡、谷口ヒロ子
  • Organizer: 第23回角膜移植学会
  • Place of Presentation: 宮崎
  • Year and Date: 2007-02-10
• [Presentation] 角膜移植におけるGlucocorticoid-Induced TNF Receptor Ligandと制御性T細胞の役割 (2007)
  • Author(s): 堀純子、王明聡、谷口ヒロ子、北原由紀、高橋浩、大島正道、東みゆき
  • Organizer: 第23回角膜移植学会
  • Place of Presentation: 宮崎
  • Year and Date: 2007-02-09
• [Presentation] 角膜移植後の免疫応答におけるB7-H3の役割 (2007)
  • Author(s): 谷口ヒロコ、堀純子、王明聡、北原由紀、大島正道、八木田秀雄
  • Organizer: 第32回角膜カンファランス
  • Place of Presentation: 千葉
• [Presentation] 角膜移植の生着におけるTim-3の役割 (2007)
  • Author(s): 冨田真智子、堀純子、王明聡、谷口ヒロコ、高橋浩、島崎潤、八木田秀雄
  • Organizer: 第32回角膜カンファランス
  • Place of Presentation: 千葉
• [Book] 難治性強膜炎へのアプローチ、「眼科薬物療法のコツと落とし穴 (2008)
  • Author(s): 堀 純子
  • Publisher: 中山書店
• [Book] Treatment of Immune mediated Ocular Diseases, Immune Response and the Eye II, ed.(J. Y. Niederkorn & H.A. Kaplan, Chemical Immunology and Allergy, Karger, Basel, Switzerland) (2007)
  • Author(s): J. Hori, J. Y. Niederkorn
  • Publisher: Corneal transplantation and Immune privilege
• [Book] Treatment of Immune mediated Ocular Diseases, Immune Response and the Eye II, ed.(J.Y. Niederkorn & H.A. Kaplan, Chemical Immunology and Allergy, Karger, Basel, Switzerland) (2007)
  • Author(s): TF Ng, H Klassen, J Hori, MJ Young
  • Publisher: Retinal transplantation