• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Genetic study for diseases of insufficient development of retinal vessels

Research Project

Project/Area Number 19592047
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionFukuoka University

Principal Investigator

KONDO Hiroyuki  Fukuoka University, 医学部, 准教授 (40268991)

Co-Investigator(Kenkyū-buntansha) HAYASHI Kenshi  九州大学, 生体防御医学研究所, 学術研究員 (00019671)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords家族性滲出性硝子体網膜症 / 未熟児網膜症 / ノリエ病 / WNTシグナル / 網膜剥離 / 新生血管 / 遺伝子 / 遺伝子診断 / TSPAN12 / Stickler症候群 / PAX3 / 網膜疾患 / SuperTopflash
Research Abstract

Diseases of insufficient development of retinal vessels are either congenital or acquired diseases that affect vision of infants and children secondary to retinal detachment. The diseases, exemplified by familial exudative vitreoretinopathy and retinopathy of prematurity, are clinically and genetically heterogeneous, and the underlying genetic factors remain to be elucidated. We evaluated the genetic factors by analyzing the patients or using experimental methods to develop a way for future prevention and the treatment.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (51 results)

All 2010 2009 2008 2007

All Journal Article (29 results) (of which Peer Reviewed: 21 results) Presentation (22 results)

  • [Journal Article] Mutations in TSPAN12 cause autosomal-dominant familial exudative vitreoretinopaty.2010

    • Author(s)
      Poulter JA, Ali M, Gilmour DF, Rice A, Kondo H, et al.
    • Journal Title

      Am J Hum Genet 86

      Pages: 248-252

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutations in TSPAN12 cause autosomal-dominant familial exsudative vitreoretinopaty2010

    • Author(s)
      Poulter JA, Ali M, Gilmour DF, Rice A, Kondo H, et al.
    • Journal Title

      Am J Hum Genet 86

      Pages: 248-252

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 増殖性硝子体網膜症に対して硝子体手術を行った小児の眼限局型Stickler症候群の1例2010

    • Author(s)
      日吉篤史、近藤寛之、原潤、吉田茂生、内尾英一
    • Journal Title

      眼科手術 23

      Pages: 163-166

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lens-sparing vitrectomy effective for reattachment of newly developed falciform retinal detachment in a patient with Norrie disease.2009

    • Author(s)
      Shima C, Kusaka S, Kondo H, Hasebe H, Fujikado T, Tano Y
    • Journal Title

      Arch Ophthalmol 127

      Pages: 579-580

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel mutation in PAX3 gene in Waardenburg syndrome accompanied by unilateral macular degeneration.2009

    • Author(s)
      Kozawa M, Kondo H, Tahira T, Hayashi K, Uchio E
    • Journal Title

      Eye 23

      Pages: 1619-1621

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Late recurrence of retinal detachment following successful vitreous surgery for stages 4B and 5 retinopathy of prematurity.2009

    • Author(s)
      Kondo H, Arita N, Ohsato M, Hayashi H, Uchio E, Oshima K
    • Journal Title

      Am J Ophthalmol 147

      Pages: 661-666

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lens-sparing vitrectomy effective for reattachment of newly developed falciform retinal detachment in a patient with Norrie disease2009

    • Author(s)
      Shima C, Kusaka S, Kondo H, et al.
    • Journal Title

      Arch Ophthalmol 127

      Pages: 579-580

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel mutation in PAX3 gene in Waardenburg syndrome accompanied by unilateral macular degeneration2009

    • Author(s)
      Kozawa M, Kondo H, Tahira T, et al.
    • Journal Title

      Eye 23

      Pages: 1619-1621

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 家族性滲出性硝子体網膜症2009

    • Author(s)
      近藤寛之
    • Journal Title

      眼臨紀 2

      Pages: 351-356

    • NAID

      10024807294

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 光凝固の適応と病期分類(特集未熟児網膜症診療-最近の考え方)2009

    • Author(s)
      近藤寛之
    • Journal Title

      あたらしい眼科 26

      Pages: 449-453

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 壮年期発症の眼底所見が軽微な錐体杆体ジストロフィの1例2009

    • Author(s)
      原潤、近藤寛之、林英之、内尾英一、藤原恵理子、林研
    • Journal Title

      臨眼 63

      Pages: 1155-1158

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stickler症候群が疑われた小児の裂孔原性網膜剥離の1例2009

    • Author(s)
      北崎理沙、右田博敬、有田直子、近藤寛之、内尾英一
    • Journal Title

      眼臨紀 2

      Pages: 835-837

    • NAID

      10025557217

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aggressive posterior retinopathy of prematurityの臨床経過と治療成績2009

    • Author(s)
      有田直子、近藤寛之、林英之、内尾英一
    • Journal Title

      臨眼 63

      Pages: 1081-1085

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Late recurrence of retinal detachment following successful vitreous surgery for stages 4B and 5 retinopathy of prematurity2009

    • Author(s)
      Kondo H, Arita N, Osato M, Hayashi H, et al.
    • Journal Title

      Am J Ophthalmol 147

      Pages: 661-666

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 未熟児網膜症に対する私の考え方-基礎研究から-2009

    • Author(s)
      近藤寛之
    • Journal Title

      眼科臨床紀要 2

      Pages: 11-15

    • NAID

      10024806657

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 家族性滲出性硝子体網膜症(小児眼科学会講習会「小児網膜疾患の病態・治療」)2009

    • Author(s)
      近藤寛之
    • Journal Title

      眼科臨床紀要 2

      Pages: 351-356

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 特集未熟児網膜症診療の最前線硝子体手術の功罪2009

    • Author(s)
      近藤寛之
    • Journal Title

      臨床眼科 63

      Pages: 152-158

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 網膜硝子体診療update IV. 注目の疾患その他・黄斑ジストロフィ2009

    • Author(s)
      近藤寛之
    • Journal Title

      臨床眼科 62

      Pages: 374-382

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Moderate reduction of Norrin signaling activity associated with the causative missense mutations identified in patients with familial exudative vitreoretinopathy.2008

    • Author(s)
      Qin M, Kondo H, Tahira T, Hayashi K
    • Journal Title

      Hum Genet 122

      Pages: 615-623

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 遺伝子診断を行ったノリエ病2家系の臨床像2008

    • Author(s)
      宮河あやこ, 近藤寛之, 林英之, 他
    • Journal Title

      眼科臨床紀要 1

      Pages: 453-456

    • NAID

      10024295594

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 家族性惨出性硝子体網膜症の原因遺伝子の骨密度への影響2008

    • Author(s)
      中森玄司, 近藤寛之, 内尾英一
    • Journal Title

      眼科臨床紀要 1

      Pages: 1094-1097

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Moderate reduction of Norrin signaling activity associated with the causative missense mutations identified in patients with familial exudative vitreoretinopathy2008

    • Author(s)
      Qin M, Kondo H, Tahira T, Hayashi K
    • Journal Title

      Hum Genet 122

      Pages: 615-623

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特集網膜病変の最近の考え方と新しい知見家族性滲出性硝子体網膜症2008

    • Author(s)
      近藤 寛之
    • Journal Title

      臨床眼科 62

      Pages: 138-144

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Severe Form of Familial Exudative Vitreoretinopathy Caused by Homozygous R417Q Mutation in Frizzled-4 Gene.2007

    • Author(s)
      Kondo H, Qin M, Tahira T, Uchio E, Hayashi K
    • Journal Title

      Ophthalmic Genet 28

      Pages: 220-223

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Severe Form of Famital Exudative Vitreoretinopathy Caused by Homozygous R417Q Mutation in Frizzled-4 Gene2007

    • Author(s)
      Kondo H, Qin M, Tahira T, Uchio E, Hayashi K
    • Journal Title

      Ophthalmic Genet 28

      Pages: 220-223

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 小児眼科に役立つ遺伝子診断・遺伝的異質性の考え方2007

    • Author(s)
      近藤 寛之
    • Journal Title

      眼科臨床医報 101

      Pages: 505-507

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 超低出生体重児の予後.超低出生体重児における未熟児網膜症の視覚予後2007

    • Author(s)
      近藤 寛之
    • Journal Title

      周産期医学 37

      Pages: 501-506

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 眼科専門医に必要な全身疾患と眼のすべて.色素失調症2007

    • Author(s)
      近藤 寛之
    • Journal Title

      臨床眼科 61

      Pages: 286-289

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 生後4週目に光凝固を行った色素失調症の1例2007

    • Author(s)
      淵上 あき, 近藤 寛之, 林 英之, 内尾 英一
    • Journal Title

      眼科臨床医報 101

      Pages: 529-531

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 黄斑部疾患の硝子体手術:適応の選択2009

    • Author(s)
      近藤寛之
    • Organizer
      第30回産業医大研究会
    • Place of Presentation
      北九州(産業医科大学)
    • Year and Date
      2009-11-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] 福山型筋ジストロフィの重症例にみられた陰性ERG所見2009

    • Author(s)
      近藤寛之, 他
    • Organizer
      第57回日本臨床視覚電気生理学会
    • Place of Presentation
      千葉(浦安市民プラザwave101)
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] わが国の常染色体優性家族性滲出性硝子体網膜症の遺伝子診断に基づいた浸透率.2009

    • Author(s)
      近藤寛之、林健志, 他
    • Organizer
      第63回日本臨床眼科学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-10-10
    • Related Report
      2009 Final Research Report
  • [Presentation] わが国の常染色体優性家族性滲出性硝子体網膜症の遺伝子診断に基づいた浸透率2009

    • Author(s)
      近藤寛之, 他
    • Organizer
      第63回日本臨床眼科学会
    • Place of Presentation
      福岡(マリンメッセ福岡)
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 小児・若年性網膜疾患の診断の新たな展開2009

    • Author(s)
      近藤寛之
    • Organizer
      第79回九州眼科学会
    • Place of Presentation
      福岡(アクロス福岡)
    • Year and Date
      2009-05-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 小児眼底疾患の診断と治療「硝子体変性症」.2009

    • Author(s)
      近藤寛之
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-17
    • Related Report
      2009 Final Research Report
  • [Presentation] 小児眼底疾患の診断と治療「硝子体変性症」2009

    • Author(s)
      近藤寛之
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京(東京国際フォーラム)
    • Year and Date
      2009-04-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 連鎖解析的手法により新規COL2A1遺伝子異常を同定したstickler症候群の1家系2009

    • Author(s)
      近藤寛之, 他
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京(東京国際フォーラム)
    • Year and Date
      2009-04-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Genetic heterogeneity in familial exudative vitreoretinopathy with reduced bone mineral density2009

    • Author(s)
      Kondo H, Nakamori G, Qin M, Tahira T, Uchio E, Hayashi K
    • Organizer
      ARVO Annual Meeting
    • Place of Presentation
      Fort Lauderdale
    • Year and Date
      2009-01-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] IKBKG遺伝子解析を行った色素失調症の4家系の臨床像2008

    • Author(s)
      近藤寛之, ファンジェーン, 内尾英一
    • Organizer
      第62回臨床眼科学会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] Aggressive posterior ROPの臨床経過と治療成績2008

    • Author(s)
      有田直子, 近藤寛之, 林英之, 内尾英一
    • Organizer
      第62回臨床眼科学会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] 小児網膜疾患の病態・治療. 1. に家族性滲出性硝子体網膜症の病態・遺伝2008

    • Author(s)
      近藤寛之
    • Organizer
      日本小児眼科学会講習会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] Genetic heterogeneityin familial exudative vitreoretinopathywith reduced bone mineral density2008

    • Author(s)
      Kondo H, Nakamori G, Qin M, Tahira T, Uchio E, Hayashi K
    • Organizer
      ARVO Annual Meeting
    • Place of Presentation
      Fort Lauderdale
    • Year and Date
      2008-04-29
    • Related Report
      2009 Final Research Report
  • [Presentation] Late recurrence of retinal detachment following successful vitreous surgery for stages 4B and 5 retinopathy of prematurity2008

    • Author(s)
      Kondo H
    • Organizer
      Association of Pediatric Retinal Surgeons Meeting
    • Place of Presentation
      Duck Key, Florida
    • Year and Date
      2008-04-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] シンポジウム10. 重症未熟児網膜症に対する初期手術選択と適応. 「硝子体手術の功罪」2008

    • Author(s)
      近藤寛之
    • Organizer
      第112回日本眼科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-04-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 常染色体優性遺伝性の前眼部形成異常を伴う小眼球症に対する遺伝子解析2007

    • Author(s)
      近藤 寛之, 秦明 輝, 田平 知子, 中森 玄司, 内尾 英一, 林健 志
    • Organizer
      第61回日本臨床眼科学会
    • Place of Presentation
      京都
    • Year and Date
      2007-10-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] シンポジウム:未熟児網膜症に対する私の考え方1.基礎研究から2007

    • Author(s)
      近藤 寛之
    • Organizer
      第32回日本小児眼科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-06-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] 基調講演v.遺伝的背景から見た網膜疾患.2007

    • Author(s)
      近藤寛之
    • Organizer
      第7 7回九州眼科学会
    • Place of Presentation
      宮崎
    • Year and Date
      2007-05-11
    • Related Report
      2009 Final Research Report
  • [Presentation] 基調講演V.遺伝的背景から見た網膜疾患2007

    • Author(s)
      近藤 寛之
    • Organizer
      第77回九州眼科学会
    • Place of Presentation
      宮崎
    • Year and Date
      2007-05-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Clinical and Genetic Characteristics of a Japanese Family with Bilateral Microphathalmia, Cataract and the Absence of Pupil Formation2007

    • Author(s)
      Kondo H, Qin M, Tahira T、 Uchio E, Hayashi K
    • Organizer
      ARVO Annual Meeting
    • Place of Presentation
      Fort Lauderdale
    • Year and Date
      2007-05-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] 家族性滲出性硝子体網膜症の遺伝子変異とwntシグナル古典的経路の転写活性の変化.2007

    • Author(s)
      近藤寛之, 秦明輝, 田平知子, 内尾英一, 林健志
    • Organizer
      第111回日本眼科学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-19
    • Related Report
      2009 Final Research Report
  • [Presentation] 家族性滲出性硝子体網膜症の遺伝子変異とWNTシグナル古典的経路の転写活性の変化2007

    • Author(s)
      近藤 寛之, 秦明 輝, 田平 知子, 内尾 英一, 林健 志
    • Organizer
      第111回日本眼科学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-19
    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi