New strategy for congenital diaphragmatic hernia based on the metabolism of extracellular matrix
| Project/Area Number |
19592061
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
MASUMOTO Kouji Kyushu University, 大学病院, 講師 (20343329)
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| Co-Investigator(Kenkyū-buntansha) |
TAGUCHI Tomoaki 九州大学, 医学研究院, 教授 (20197247)
KINOSHITA Yoshiaki 九州大学, 医学研究院, 助教 (80345529)
NAGATA Kouji 九州大学, 大学病院, 医員 (20419568)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 先天性横隔膜ヘルニア / 肺低形成 / 細胞外マトリックス / ギャップジャンクション / 胎児治療 / 肺発達 |
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| Research Abstract |
先天性横隔膜ヘルニアの新たな胎児治療戦略として、細胞外マトリックス代謝からの戦略を行うための基礎実験を行った。低形成肺のモデルとして、通常使用されるNitrofen-inducedモデルや新たなモデルとしてGja-1 knock-outモデルを使用し、その発達の程度を検討した。またコラーゲンなどの細胞外マトリックスやその分解酵素について、分布やタンパク発現量を検討した。どちらの低形成肺でも、発達がきわめて遅れており、組織培養を行い、成長因子などの投与によりこの発達の遅れが改善する可能性が示唆された。
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] Improvement in the outcome of patients with antenatally diagnosed congenital diaphragmatic hernia using gentle ventilation and circulatory stabilization2009
Author(s)
Masumoto K, Teshiba R, Esumi G, Nagata K, Takahata Y, Hikino S, Hara T, Hojo S, Tsukimori K, Wake N, Kinukawa N, Taguchi T
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Journal Title
Pediatr Surg Int (accepted)
NAID
Related Report
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[Journal Article] Clinical features of selenium deficiency in infants receiving long-term nutritional support2007
Author(s)
Masumoto K, Nagata K, Higashi M, Nakatsuji T, Uesugi T, Takahashi Y, Nishimoto Y, Kitajima J, Hikino S, Hara T, Nakashima K, Nakashima K, Oishi R, Taguchi T
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Journal Title
Nutrition 23(11-12)
Pages: 782-7
Related Report
Peer Reviewed
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[Presentation] Dramatic improvement in the outcome of patients with antenatally diagnosed congenital diaphragmatic hernia using gentle ventilation and circulatory stabilization2008
Author(s)
Masumoto K, Teshiba R, Esumi G, Nagata K, Takahata Y, Hara H, Hojo S, Tsukimori K, Wake N, Kinukawa N, and Taguchi T
Organizer
15th congress of the Federation of Asia and Oceania Perinatal Societies
Place of Presentation
Nagoya
Related Report
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[Presentation] Dramatic improvement in the outcome of patients with antenatally diagnosed congenital diaphragmatic hernia using gentle ventilation and circulatory stabilization2008
Author(s)
Masumoto K, Teshiba R, Esumi G, Nagata K, Takahata Y, Hara T, Hojo S, Tsukimori K, Wake N, Kinukawa N, Taguchi T
Organizer
41^<st> Annual meeting of Pacific Association of Pediatric Surgeons
Place of Presentation
Jackson, Wyoming, USA
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