Mechanism of angiogenesis for adipocytes for the application to the stable transplantation technique

• Project/Area Number: 19592069
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: Chiba University
• Principal Investigator: RIKIHISA Naoaki Chiba University, 医学部・附属病院, 助教 (60436433)
• Co-Investigator(Kenkyū-buntansha): BUJO Hideaki 千葉大学, 大学院・医学研究院, 教授 (80291300) ; ICHINOSE Masaharu 千葉大学, 大学院・医学研究院, 教授 (90082156) ; SAITO Yasushi 千葉大学, 大学院・医学研究院, 教授 (50101358) ; UNOKI Hiroyuki 千葉大学, 大学院・医学研究院, 助教 (40323290)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 移植 / 脂肪細胞 / 脂肪組織 / 血管新生 / 細胞外マトリクス / 生存 / bFGF / マトリックス / 生着

Research Abstract

本研究の目的は移植脂肪組織の生着率を向上させる安全な細胞外環境と血管新生誘導因子を明らかにすることである。研究成績から脂肪移植の生存率の向上に脂肪細胞の機能発現を制御することが関わること、そのために細胞外環境との密接なインターラクションが重要であり、MMP発現を充進する作用を有する活性物質の長期補充により移植脂肪の生着率を充進することが可能であることが明らかになった。

Research Products

• [Journal Article] Macrophages regulate tumor necrosis factor-alpha expression in adipocytes through the secretion of matrix metalloproteinase-3 (2008)
  • Author(s): Unoki H, Bujo H, Jiang M, Kawamura T, Murakami K, Saito Y.
  • Journal Title: Int. J. Obes 32 Pages: 902-911
  • Peer Reviewed
• [Journal Article] Low-dose GH supplementation reduces the TLR2 and TNF-alpha expressions in visceral fat (2008)
  • Author(s): Kubota Y, Unoki H, Bujo H, Rikihisa N, Udagawa A, Yoshimoto S, Ichinose M, Saito Y.
  • Journal Title: Biochem. Biophys. Res. Commun. 368 Pages: 81-87
  • Peer Reviewed
• [Journal Article] Matrix metalloproteinase-3 enhances the free fatty acids-induced VEGF expression in adipocytes through toll-like receptor 2 (2008)
  • Author(s): Kawamura T, Murakami K, Bujo H, Unoki H, Jiang M, Nakayama T, Saito Y.
  • Journal Title: Exp.Biol. Med. (Maywood) 233 Pages: 1213-1221
  • Peer Reviewed
• [Journal Article] Matrix metalloproteinase 2 improves the transplanted adipocyte survival in mice (2008)
  • Author(s): Kuramochi D, Unoki H, Bujo H, Kubota Y, Jiang M, Rikihisa N, Udagawa A, Yoshimoto S, Ichinose M, Saito Y.
  • Journal Title: Eur. J. Clin. Invest. 38 Pages: 752-759
  • Peer Reviewed
• [Journal Article] Low-dose GH supplementation reduces the TLR2 and TNF-alpha expressions in visceral fat. (2008)
  • Author(s): Kubota Y, Unoki H, Bujo H, Rikihisa N, Udagawa A, Yoshimoto S, Ichinose M, Saito Y.
  • Journal Title: Biochem. Biophys. Res. Commun. 368 Pages: 81-87
  • Peer Reviewed
• [Journal Article] Matrix metalloproteinase-3 enhances the free fatty acids-induced VEGF expression in adipocytes through toll-like receptor 2. (2008)
  • Author(s): Kawamura T, Murakami K, Bujo H, Unoki H, Jiang M, Nakayama T, Saito Y.
  • Journal Title: Exp. Biol. Med.(Maywood) 233 Pages: 1213-21
  • Peer Reviewed
• [Journal Article] Basic fibroblast growth factor ameliorates the survival of transplanted adipocytes thlough matrix metalloproteinase 2 in mice. (2008)
  • Author(s): Kuramochi D, Unoki H, Bujo H, Kubota Y, Jiang M, Rikihisa N, Udagawa A, Yoshimoto S, Ichinose M, Saito Y.
  • Journal Title: Eur.J.Clin.Invest. 38 Pages: 752-59
  • Peer Reviewed
• [Journal Article] Low-dose GH supplementation reduces the TLR2 and TNF-alpha expressions in visceral fat (2008)
  • Author(s): Kubota Y, Unoki H, Bujo H, Rikihisa N, Udagawa A, Yoshimoto S, Ichinose M, Saito Y
  • Journal Title: Biochem Biophys Res Commun 368 Pages: 81-87
  • Peer Reviewed