Angiopoietin-related growth factor promotes sensitivity to ultraviolet B-induced cutaneous photodamag

• Project/Area Number: 19592077
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: Ehime University
• Principal Investigator: NAKAOKA Hiroki Ehime University, 医学部・附属病院, 講師 (30172266)
• Co-Investigator(Kenkyū-buntansha): HIRAKAWA Satoshi 愛媛大学, 医学部・附属病院, 講師 (50419511)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 光老化 / 血管新生 / 細胞外マトリックス / 動物モデル / 炎症 / 増殖因子 / 予防医学 / 細胞・組織

Research Abstract

表皮特異的AGFトランスジェニック・マウス(AGF TG)に紫外線UVBを単回照射すると、野生型に比べて光線過敏を来たした。即ち、皮膚毛細血管は拡張し、表皮は肥厚、皮膚の腫脹が持続し、炎症が遷延することが示唆された。さらに、慢性的にUVB照射を行うと、AGF TGでは皮膚に皺が生じた。このことから、AGFは光老化を来す因子であることが同定された。

Research Products

• [Journal Article] From tumor lymphangiogeneis to lymphvascular niche. (2009)
  • Author(s): Hirakawa s.
  • Journal Title: Cancer Sci 印刷中
  • Peer Reviewed
• [Journal Article] VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites (2007)
  • Author(s): Hirakawa S, et. al.
  • Journal Title: Blood 109 Pages: 1010-1017
  • Peer Reviewed
• [Journal Article] STAT5a/PPARgamma pathway regulates regulates involucrin expression in keratinocyte differentiation (2007)
  • Author(s): Dai X, et. al.
  • Journal Title: J Invest Dermatol 127 Pages: 1728-1735
  • Peer Reviewed
• [Journal Article] Suppressor of cytckine signaling 3 negalive regulation of signal transducer and activator of transorption 3 in platelet-derived growth factor-induced fibroblast migration (2007)
  • Author(s): Nagai H, et. al.
  • Journal Title: J Dermatol 34 Pages: 523-530
  • Peer Reviewed
• [Presentation] 皮膚炎症における血管・リンパ管新生-VEGF-Aトランスジェニックマウスから得られた新たな知見 (2007)
  • Author(s): 平川 聡史
  • Organizer: 第28回日本炎症・再生医学会
  • Place of Presentation: 京王プラザホテル
  • Year and Date: 2007-08-02
• [Presentation] Targeted overexpression of angiopoietin-related growth factor promotes lymphatic and epidermal hyperplasia in the skin (2007)
  • Author(s): Hirakawa S, Sato E, Arima Y, Shirakata Y, Sayama K, Toyama M, Tokumaru S, Nagai H, Oike Y, and Hashimoto K.
  • Organizer: 37^<th> Annual European Society for Dermatological Research (ESDR) Meeting, Zurich, Switzerland
  • Place of Presentation: Oral presentation in plenary session
• [Presentation] Targeted overexpression of angiopoietin-related growth factor in the epidermis promotes lymphatic and epidermal hyperplasia (2007)
  • Author(s): Sato E, Hirakawa S, Arima Y, Shirakata Y, Sayama K, Tohyama M, Tokumaru S, Nagai Hi, Oike Y, Hashimoto K.
  • Organizer: The 32^<nd> Annual Meeting of The Japanese Society for Investigative Dermatology, Yokohama
  • Place of Presentation: Oral presentation
• [Book] Dermatology (2008)
  • Author(s): Detmar M, Hirakawa S.
  • Publisher: MOSBY ELSEVIER