Study of three-dimensional bone formation induced with adipose tissue derived stem cells
| Project/Area Number |
19592081
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Kansai Medical University |
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Principal Investigator |
KUSUMOTO Kenji Kansai Medical University, 医学部, 教授 (20161630)
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| Co-Investigator(Kenkyū-buntansha) |
ONISHI Sayuri 関西医科大学, 医学部, 助教 (50440970)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 生物・生物工学 / 移植・再生医療 / バイオテクノロジー / 脂肪組織 / 幹細胞 / 骨 / 骨新生 / 再建 / 生物・生体工学 / 再生医学 |
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| Research Abstract |
Human adipose-derived stem cells (ASCs) have the capacity to regenerate and the potential to differentiate into multiple lineages of mesenchymal cells, bone, cartilage, and fat cells. The ASC-loaded honeycomb collagen scaffolds cultured for 14 days were subcutaneously transplanted into nude mice, and excised after 8 weeks. Bone formation in vivo was examined using HE stain, von Kossa stain, and osteocalcin immunostain. These results suggest that this carrier is a suitable scaffold for ASCs and will be useful as a three-dimensional bone tissue engineering scaffold in vitro and in vivo.
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Report
(4 results)
Research Products
(24 results)
