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Establishment of antibody titer measurement against Vibrio vulnificus

Research Project

Project/Area Number 19592091
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionSaga University

Principal Investigator

ARAKI Kazukuni  Saga University, 医学部, 准教授 (50193066)

Co-Investigator(Kenkyū-buntansha) MITHUMIZO Shinji  佐賀大学, 医学部, 講師
NAKASHIMA Mikio  佐賀大学, 医学部, 教授 (70315191)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords集中治療医学 / Vibrio vulnificus / Micro-IF / 血清抗体価 / 血清抗体価測定法 / 壊死性筋膜炎 / Micro-IF assay / micro-IF assay
Research Abstract

We studied blood plasma IgG antibody (IgG Ab) titer in Vibrio vulnificus patients and two control groups(chronic liver dysfunction group and normal liver function group). To determine the Vibrio vulnificus antigens, we investigated two-dimensional gel electrophoresis and western blot. We discovered the time course of IgG Ab titer and specific antigen. Although we could not conclude that the IgG Ab titer analysis system is useful for screening for people who are susceptible to Vibrio vulnificus infection, it seems possible to predict the prognosis of the patients.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (20 results)

All 2009 2008 2007

All Journal Article (20 results) (of which Peer Reviewed: 7 results)

  • [Journal Article] ビブリオ・バルニフィカス感染症対策臨床医学的アプローチ(第四報)2009

    • Author(s)
      中島幹夫, 大石浩隆, 松本浩一, 冨田由紀子, 三溝慎次, 荒木和邦
    • Journal Title

      佐賀大学有明海総合研究プロジェクト成果報告集 第5巻

      Pages: 141-146

    • Related Report
      2009 Final Research Report
  • [Journal Article] ビブリオバルニフィカス感染症対策-臨床医学的アプローチ-(第四報)2009

    • Author(s)
      中島幹夫
    • Journal Title

      佐賀大学有明海総合研究プロジェクト成果報告集 5

      Pages: 141-146

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 佐賀大学医学部附属病院における壊死性筋膜炎55例の検討2009

    • Author(s)
      三溝慎次
    • Journal Title

      佐賀大学有明海総合研究プロジェクト成果報告集 5

      Pages: 159-162

    • Related Report
      2009 Annual Research Report
  • [Journal Article] ビブリオ・バルニフィカス感染症対策臨床医学的アプローチ(第三報)2008

    • Author(s)
      中島幹夫, 大石浩隆, 冨田由紀子, 松本浩一, 前田祥範, 三溝慎次, 荒木和邦
    • Journal Title

      佐賀大学有明海総合研究プロジェクト成果報告集 第4巻

      Pages: 131-136

    • Related Report
      2009 Final Research Report
  • [Journal Article] ビブリオ・バルニフィカス感染症対策基礎医学的アプローチ(第三報)2008

    • Author(s)
      大石浩隆, 中島幹夫, 田代幸寛, 他4名
    • Journal Title

      佐賀大学有明海総合研究プロジェクト成果報告集 第4巻

      Pages: 137-142

    • Related Report
      2009 Final Research Report
  • [Journal Article] Clinical features and an epidemiological review of vidrio vulnificus infections in Japan2008

    • Author(s)
      Koichi Matsumoto
    • Journal Title

      Antibiotics and Chemotherapy 24

      Pages: 81-88

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid Detection of Vibrio vulnificus Using a Loop-mediated Isothermal Amplication Method2008

    • Author(s)
      Jiro Nemoto
    • Journal Title

      The Journal of the Japanese Association for Infectious Diseases 82

      Pages: 407-413

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ビブリオ・バルニフィカス感染症対策-臨床医学的アプローチ-(第三報)2008

    • Author(s)
      中島幹夫
    • Journal Title

      佐賀大学有明海総合研究プロジェクト成果報告集 4

      Pages: 131-136

    • Related Report
      2008 Annual Research Report
  • [Journal Article] ビブリオ・バルニフィカス感染症対策-基礎医学的アプローチ-(第三報)2008

    • Author(s)
      大石浩隆
    • Journal Title

      佐賀大学有明海総合研究プロジェクト成果報告集 4

      Pages: 137-142

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 救命しえたA群β溶血連鎖球菌毒素性ショック症候群の1例2008

    • Author(s)
      三溝慎次
    • Journal Title

      佐賀大学有明海総合研究プロジェクト成果報告集 4

      Pages: 143-146

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Loop-mediated Isothermal Amplication (LAMP)法を利用した起炎菌迅速診断法の検討2008

    • Author(s)
      草場耕二
    • Journal Title

      佐賀大学有明海総合研究プロジェクト成果報告集 4

      Pages: 147-150

    • Related Report
      2008 Annual Research Report
  • [Journal Article] A fatal case of necrotizing fasciitis due to bacterial translocation of Klebsiella oxytoca2008

    • Author(s)
      Hirotaka Oishi
    • Journal Title

      Journal of Infection and Chemotherapy 14

      Pages: 62-65

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Survived Case of Vibrio Vulnificus Infections with Multiple Endocrine Neoplasia Type I2007

    • Author(s)
      Hiroko Amemori, Masaki Hyakutake, Yoshinori Maeda, Yukiko Tomita, Shinji Mitsumizo, Hirotaka Oishi, Shunzo Koizumi, Mikio Nakashima, Kazukuni Araki
    • Journal Title

      Fukuoka Acta Medica 98(9)

      Pages: 346-352

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] ビブリオ・バルニフィカス感染症対策基礎医学的アプローチ(第二報)2007

    • Author(s)
      大石浩隆, 中島幹夫, 中島由佳理, 他3名
    • Journal Title

      佐賀大学有明海総合研究プロジェクト成果報告集 第3巻

      Pages: 153-158

    • Related Report
      2009 Final Research Report
  • [Journal Article] ビブリオ・バルニフィカス感染症対策臨床医学的アプローチ(第二報)2007

    • Author(s)
      中島幹夫, 大石浩隆, 浦由紀子, 前田祥範, 三溝慎次, 荒木和邦
    • Journal Title

      佐賀大学有明海総合研究プロジェクト成果報告集 第3巻

      Pages: 147-152

    • Related Report
      2009 Final Research Report
  • [Journal Article] A survived case of Vibrio vulnificus infection with multiple endocrine neoplasia type I2007

    • Author(s)
      Hiroko Amemori
    • Journal Title

      Fukuoka Acta Medica 98

      Pages: 346-352

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A chromogenic substrate culture plate for early identification of Vibrio vulnificus and isolation of other marine Vibrios2007

    • Author(s)
      Yukari Nakashima
    • Journal Title

      Annals of Clinical and Laboratory Science 37

      Pages: 330-334

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Iodoform intoxication; A case report of prolonged consciousness disturbance in a patient with a high plasma iodine level2007

    • Author(s)
      Kazukuni Araki
    • Journal Title

      Fukuoka Acta Medica 98

      Pages: 397-401

    • NAID

      40015832062

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ビブリオ・バルニフィカス感染症対策-臨床医学的アプローチー(第二報)2007

    • Author(s)
      中島 幹夫
    • Journal Title

      佐賀大学有明海総合研究プロジェクト成果報告集 3

      Pages: 147-152

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 当院で経験した敗血症性ショックの2症例2007

    • Author(s)
      三溝 慎次
    • Journal Title

      佐賀大学有明海総合研究プロジェクト成果報告集 3

      Pages: 159-162

    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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