Effects of atropine and oximes on neuronal actions of organophospholus cholinesterase inhibitors.
| Project/Area Number |
19592093
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
NARIMATSU Eichi Sapporo Medical University, 医学部, 准教授 (70295343)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAMATA Mikito 信州大学, 医学部, 教授 (90315523)
KAWAMATA Tomoyuki 信州大学, 医学部, 准教授 (80336388)
NIIYA Tomohisa 札幌医科大学, 医学部, 助教 (80510312)
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 海馬 / 伝達 / 有機リン剤 / オキシム剤 / アトロピン / 海馬スライス / 興奮性シナプス伝達 / グルタミン酸 / アセチルコリン / パラオキソン / プラリドキシム / コリンエステラーゼ / シナプス伝達 / 神経筋接合部 / パラチオン / ロクロニウム |
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| Research Abstract |
We investigated influences of paraoxon (an organophospholus cholinesterase inhibitor), atropine and pralidoxime (an oxime) on glutamatergic excitatory synaptic transmission and neuronal somatic excitability using rat hippocampal slices. Paraoxon depressed the excitatory synaptic transmission and facilitates the excitability. Pralidoxime and atropine prevent and depress the actions of paraoxon and are more effective with earlier treatment.
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Report
(6 results)
Research Products
(36 results)
