Effects of atropine and oximes on neuronal actions of organophospholus cholinesterase inhibitors.

• Project/Area Number: 19592093
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Sapporo Medical University
• Principal Investigator: NARIMATSU Eichi Sapporo Medical University, 医学部, 准教授 (70295343)
• Co-Investigator(Kenkyū-buntansha): KAWAMATA Mikito 信州大学, 医学部, 教授 (90315523) ; KAWAMATA Tomoyuki 信州大学, 医学部, 准教授 (80336388) ; NIIYA Tomohisa 札幌医科大学, 医学部, 助教 (80510312)
• Project Period (FY): 2007 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 海馬 / 伝達 / 有機リン剤 / オキシム剤 / アトロピン / 海馬スライス / 興奮性シナプス伝達 / グルタミン酸 / アセチルコリン / パラオキソン / プラリドキシム / コリンエステラーゼ / シナプス伝達 / 神経筋接合部 / パラチオン / ロクロニウム

Research Abstract

We investigated influences of paraoxon (an organophospholus cholinesterase inhibitor), atropine and pralidoxime (an oxime) on glutamatergic excitatory synaptic transmission and neuronal somatic excitability using rat hippocampal slices. Paraoxon depressed the excitatory synaptic transmission and facilitates the excitability. Pralidoxime and atropine prevent and depress the actions of paraoxon and are more effective with earlier treatment.

Research Products

• [Journal Article] Effects of atropine and pralidoxime on neuronal actions of paraoxon in rat hippocampal slices. (2010)
  • Author(s): Narimatsu Eichi, Niiya Tomohisa, Kawamata Tomoyuki, Kawamata Mikito, Yamakage Michiaki
  • Journal Title: Neurosci Res 68 Pages: 276-84
  • Peer Reviewed
• [Journal Article] Effects of atropine and pralidoxime on neuronal actions of paraoxon in rat hippocampal slices. (2010)
  • Author(s): Narimatsu E, Niiya T, Kawamata T, Kawamata M, Yamakage M.
  • Journal Title: Neuroscience Research Volume: 68 Pages: 276-284
  • Peer Reviewed
• [Journal Article] Effects of sepsis on the neuromuscular blocking actions of d-tubocurarine on rat adductor and abductor laryngeal muscules. (2009)
  • Author(s): Nishikawa Kouki, Narimatsu Eichi, Igarashi Motohiko, Namiki Akiyoshi
  • Journal Title: J Anesth 23 Pages: 520-525
  • Peer Reviewed
• [Journal Article] 筋弛緩薬の基礎-神経筋接合部に対する非脱分極性筋弛緩薬の作用- (2009)
  • Author(s): 成松英智, 新谷知久
  • Journal Title: Pharacoanesthesiology 20 Pages: 22-28
  • Peer Reviewed
• [Journal Article] 神経筋接合部を意識した筋弛緩投与法とモニタリング-種々の病態での神経筋接合部の変化と筋弛緩モニタリングの留意点- (2009)
  • Author(s): 成松英智, 新谷知久, 並木昭義
  • Journal Title: 日本臨床麻酔学会誌 29 Pages: 23-34
  • Peer Reviewed
• [Journal Article] Effects of sepsis on the neuromuscular blocking actions of d-tubocurarine on rat adductor and abductor laryngeal muscules. (2009)
  • Author(s): Nishikawa K, Narimatsu E, Igarashi M, Namiki A
  • Journal Title: J Anesth 23 Pages: 520-525
  • Peer Reviewed
• [Journal Article] Effects of sepsis on the neuromuscular blocking actions of d-tubocurarine on rat adductor and abductor laryngeal muscules (2009)
  • Author(s): Nishikawa K, Narimatsu E, et al.
  • Journal Title: Journal of Anesthesia 23 Pages: 520-525
  • Peer Reviewed
• [Journal Article] Adenosine and adenosine uptake inhibitors potentiate the neuromuscular blocking action of rocuronium mediated by adenosine A_1 receptors in isolated rat diaphragms. (2008)
  • Author(s): Narimatsu Eichi, Niiya Tomohisa, Kawamata Mikito, Namiki Akiyoshi
  • Journal Title: Acta Anesth Scand 52 Pages: 1415-22
  • Peer Reviewed
• [Journal Article] Adenosine and adenosine uptake inhibitors potentiate the neuromuscular blocking action of rocuronium mediated by adenosine A1 receptors in isolated rat diaphragms. (2008)
  • Author(s): Narimatsu E, Niiya T, Kawamata M, Namiki A
  • Journal Title: Acta Anesth Scand 52 Pages: 1415-22
  • Peer Reviewed
• [Journal Article] Adenosine and adenosine uptake inhibitors potentiate the neuromuscular blocking action of rocuronium mediated by adenosine A_1 receptors in isolated rat diaphragms. (2008)
  • Author(s): Narimatsu E, et al.
  • Journal Title: Acta Anaesth. Scand. 52 Pages: 1415-1422
  • Peer Reviewed
• [Journal Article] Lack in Effects of Therapeutic Concentrations of Dexmedetomidine and Clonidine on the Neuromuscular Blocking Action of Rocuronium in Isolated Rat Diaphragms. (2007)
  • Author(s): Narimatsu Eichi, Niiya Tomohisa, Kawamata Mikito, Namiki Akiyoshi
  • Journal Title: Anesth Analg 104 Pages: 1116-20
  • Peer Reviewed
• [Journal Article] Lack in Effects of Therapeutic Concentrations of Dexmedetomidine and Clonidine on the Neuromuscular Blocking Action of Rocuronium in Isolated Rat Diaphragms. (2007)
  • Author(s): Narimatsu E, et. al.
  • Journal Title: Anesthesia & Analgesia 104 Pages: 1116-1120
  • Peer Reviewed
• [Presentation] Effects of atropine and pralidoxime on neuronal actions of paraoxon in rat hippocampal slices. (2010)
  • Author(s): Narimatsu Eichi, Niiya Tomohisa, Kawamata Tomoyuki, Kawamata Mikito, Yamakage Michiaki
  • Organizer: In : 2010 Annual Meeting, American Society of Anesthesiologists
  • Place of Presentation: San Diego, USA
• [Presentation] 救急医療におけるDexmedetomidineの有効な使用法(ランチョンセミナー) (2010)
  • Author(s): 成松英智
  • Organizer: 第29回日本蘇生学会
  • Place of Presentation: 宇都宮
• [Presentation] Effects of atropine and pralidoxime on neuronal actions of paraoxon in rat hippocampal slices. (2010)
  • Author(s): Narimatsu E, Niiya T, Kawamata T, Kawamata M, Yamakage M.
  • Organizer: Annual Meeting, American Society of Anesthesiologists.
  • Place of Presentation: San Diego, USA.
• [Presentation] -筋弛緩拮抗はどのようにすればいいのか-筋弛緩拮抗時の神経筋伝達(シンポジウム) (2009)
  • Author(s): 成松英智
  • Organizer: 第56回日本麻酔科学会学術集会
  • Place of Presentation: 神戸
• [Presentation] -筋弛緩拮抗はどのようにすればいいのか-筋弛緩拮抗時の神経筋伝達 (2009)
  • Author(s): 成松英智
  • Organizer: 第56回日本麻酔科学会学術集会
  • Place of Presentation: 神戸
• [Presentation] 海馬興奮性シナプス伝達に対する有機リン系コリンエステラーゼ阻害薬の影響 (2008)
  • Author(s): 成松英智, 他
  • Organizer: 日本救急医学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2008-10-13
• [Presentation] 筋弛緩薬を正しく理解しよう-ロクロニウムの臨床的有用性-筋弛緩薬の基礎(シンポジウム) (2008)
  • Author(s): 成松英智
  • Organizer: 第30回日本麻酔・薬理学会
  • Place of Presentation: 京都
  • Year and Date: 2008-06-21
• [Presentation] を正しく理解しよう-ロクロニウムの臨床的有用性-筋弛緩薬の基礎(シンポジウム) (2008)
  • Author(s): 成松英智.筋弛緩薬
  • Organizer: 30回日本麻酔・薬理学会
  • Place of Presentation: 京都
  • Year and Date: 2008-06-21
• [Presentation] Effects of an organophosphate and an oxime on the neuromuscular blocking action of rocuronium. (2008)
  • Author(s): Narimatsu Eichi, Niiya Tomohisa, Kawamata Tomoyuki, Namiki Akiyoshi, Asai Yasufumi
  • Organizer: In : 2008 Annual Meeting, American Society of Anesthesiologists
  • Place of Presentation: Orlando, USA
• [Presentation] Effects of an organophosphate and an oxime on the neuromuscular blocking action of rocuronium. (2008)
  • Author(s): Narimatsu E, Niiya T, Kawamata T, Namiki A, Asai Y
  • Organizer: In: 2008 Annual Meeting, American Society of Anesthesiologists
  • Place of Presentation: Orlando, USA
• [Presentation] 海馬興奮性シナプス伝達に対する有機リン系コリンエステラーゼ阻害薬の影響 (2008)
  • Author(s): 成松英智, 新谷知久, 並木昭義, 浅井康文
  • Organizer: 第36回日本救急医学会総会
  • Place of Presentation: 札幌
• [Presentation] 筋収縮力および筋弛緩薬作用性に及ぼす有機リンおよびPAMの影響 (2007)
  • Author(s): 成松英智、他
  • Organizer: 日本救急医学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-10-18
• [Presentation] 神経筋接合部を意識した筋弛緩投与法とモニタリング種々の病態での神経筋接合部の変化と筋弛緩モニタリングの留意点(シンポジウム) (2007)
  • Author(s): 成松英智, 新谷知久, 並木昭義
  • Organizer: 第27回日本臨床麻酔学会
  • Place of Presentation: 東京
• [Presentation] Effects of Adenosine and Adenosine Uptake Inhibitors on the Action of Rocuronium In Vitro. (2007)
  • Author(s): Narimatsu Eichi, Niiya Tomohisa, Kawamata Mikito, Kiya Tomohiro, Namiki Akiyoshi
  • Organizer: In : 2007 Annual Meeting, American Society of Anesthesiologists
  • Place of Presentation: San Francisco, USA
• [Presentation] ICUせん妄に対するdexmedetomidineの有用性と患者精神状態(パネルディスカッション) (2007)
  • Author(s): 成松英智, 窪田生美, 橋本功二, 和田武志, 井上弘行, 岡本博之, 宮田圭, 浅井康文
  • Organizer: 第34回日本集中治療医学会総会
  • Place of Presentation: 神戸
• [Book] 筋弛緩薬(基礎編2.神経筋伝達の解剖と生理.Bシナプス伝達)(岩崎寛編) (2010)
  • Author(s): 成松英智, 新谷知久
  • Publisher: 克誠堂出版
• [Book] 筋弛緩薬(基礎編3.筋弛緩薬の作用機序)(岩崎寛編) (2010)
  • Author(s): 成松英智, 新谷知久
  • Publisher: 克誠堂出版
• [Book] 筋弛緩薬(基礎編2.神経筋伝達の解剖と生理.Cシナプス伝達後の筋線維収縮)(岩崎寛編) (2010)
  • Author(s): 新谷知久, 成松英智
  • Publisher: 克誠堂出版
• [Book] 基礎編3.筋弛緩薬の作用機序(pp80-100).岩崎寛編 筋弛緩薬 (2010)
  • Author(s): 成松英智, 新谷知久
  • Total Pages: 20
  • Publisher: 克誠堂出版
• [Book] すぐに役立つロクロニウムの上手な使い方(第6章-特殊な状態・病態におけるロクロニウムの使い方と留意点,(2)重症筋無力症・筋疾患などの神経筋疾患)(大下修造,他編) (2008)
  • Author(s): 成松英智, 新谷知久
  • Publisher: 日本臨床麻酔学会誌編集室
• [Book] 第6章-特殊な状態・病態におけるロクロニウムの使い方と留意点, (1)肝臓・腎臓障害および移植術.大下修造, 他編, すぐに役立つロクロニウムの上手な使い方 (2008)
  • Author(s): 新谷知久, 成松英智
  • Publisher: 日本臨床麻酔学会誌編集室
• [Book] 第6章-特殊な状態・病態におけるロクロニウムの使い方と留意点, (2)重症筋無力症・筋疾患などの神経筋疾患.大下修造, 他編, すぐに役立つロクロニウムの上手な使い方 (2008)
  • Author(s): 成松英智, 新谷知久
  • Publisher: 日本臨床麻酔学会誌編集室
• [Book] ロクロニウムの上手な使い方 第6章・特殊な状態・病態におけるロクロニウムの使い方と留意点, (2)重症筋無力症・筋疾患などの神経筋疾患 (2008)
  • Author(s): 成松英智, 他
  • Total Pages: 139
  • Publisher: 日本臨床麻酔学会誌編集室
• [Book] 第3章プレセデックスの適応外使用(5)救急領域.デクスメデトミジン (2007)
  • Author(s): 成松英智
  • Publisher: 真興交易医書出版部