Therapeutic efficacy of immunoglobulin on the multiple organ injury associated with severe sepsis

• Project/Area Number: 19592094
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Nagoya City University
• Principal Investigator: HARADA Naoaki Nagoya City University, 大学院・医学研究科, 准教授 (00309915)
• Co-Investigator(Kenkyū-buntansha): OKAJIMA Kenji 名古屋市立大学, 大学院・医学研究科, 教授 (60152295)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 免疫グロブリン / 虚血再灌流障害 / インスリン様成長因子-I / 知覚神経 / アポトーシス / 腎障害 / 脊髄後根神経節細胞 / カルシトニン遺伝子関連ペプチド / インスリン様成長因子-1 / 賢障害

Research Abstract

本研究では、人免疫グロブリン製剤(Ig)の新しい臓器保護作用を解析するためにIgがカプサイシン感受性知覚神経の活性化を促進して、虚血再灌流性臓器障害を軽減するか否かを解析した。Ig は知覚神経を刺激して、臓器保護作用に重要なインスリン様成長因子-I(IGF-I)の生成を促し、マウスの虚血再灌流性腎障害を軽減することが判明した。よって、Igは重症敗血症などによる臓器障害抑制を目的とした治療にも有用である可能性が示された

Research Products

• [Journal Article] Promotion of insulin-like growth factor-I production by sensory neuron stimulation (2008)
  • Author(s): 岡嶋研二、原田直明
  • Journal Title: molecular mechanism(s) and therapeutic implications、Current Medicinal Chemistry 15 Pages: 3095-3112
  • Peer Reviewed
• [Journal Article] Effect of capsaicin on plasma and tissue levels of insulin-like growth factor-I in spontaneously hypertensive rats (2008)
  • Author(s): 原田直明、岡嶋研二
  • Journal Title: Growth Hormone & IGF Research 18 Pages: 75-81
  • Peer Reviewed
• [Journal Article] Role of neutrophil elastase in development of pulmonary vascular injury and septic shock in rats (2008)
  • Author(s): 原田直明、岡嶋研二、礒部博隆
  • Journal Title: Shock30 Pages: 379-387
  • Peer Reviewed
• [Journal Article] Antithrombin prevents reperfusion-induced hepatic apoptosis by enhancing insulin-like growth factor-I production in mice (2008)
  • Author(s): 原田直明、岡嶋研二、栗原裕基、中潟直巳
  • Journal Title: Critical Care Medicine 36 Pages: 971-974
  • Peer Reviewed
• [Journal Article] Antithrombin inhibits LPS-induced TNF production by monocytes in vitro through inhibition of Egr-1 expression (2008)
  • Author(s): 幸村英文、内場光浩、水落雄一朗、新井正徳、原田直明、勝屋弘忠、岡嶋研二
  • Journal Title: Journal of Thrombosis and Haemostasis 6 Pages: 499-507
  • Peer Reviewed
• [Journal Article] Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans (2008)
  • Author(s): 原田直明、岡嶋研二、栗原裕基、中潟直巳
  • Journal Title: Growth Hormone & IGF Research 18 Pages: 335-344
  • Peer Reviewed
• [Journal Article] Promotion of insulin-like growth factor-I production by sensory neuron stimulation ; molecular mechanism (s) and therapeutic implications (2008)
  • Author(s): 岡嶋研二, 原田直明
  • Journal Title: Current Medicinal Chemistry 15 Pages: 3095-3112
  • Peer Reviewed
• [Journal Article] Effect of capsaicin on plasma and tissue levels of insulin-like growth factor-I in spontaneously hypertensive rats. (2008)
  • Author(s): 原田直明, 岡嶋研二
  • Journal Title: Growth Hormone & IGF Research 18 Pages: 75-81
  • Peer Reviewed
• [Journal Article] Role of neutrophil elastase in development of pulmonary vascular injury and septic shock in rats (2008)
  • Author(s): 原田直明, 岡嶋研二, 礒部博隆
  • Journal Title: Shock 30 Pages: 379-387
  • Peer Reviewed
• [Journal Article] Antithrombin prevents reperfusion-induced hepatic apoptosis by enhancing insulin-like growth factor-I production in mice. (2008)
  • Author(s): 原田直明, 岡嶋研二, 栗原裕基, 中潟直巳
  • Journal Title: Critical Care Medicine 36 Pages: 971-974
  • Peer Reviewed
• [Journal Article] Antithrombin inhibits LPS-induced TNF production by monocytes in vitro through inhibition of Egr-1 expression. (2008)
  • Author(s): 幸村英文, 内場光浩, 水落雄一朗, 新井正徳, 原田直明, 勝屋弘忠, 岡嶋研二
  • Journal Title: Journal of Thrombosis and Haemostasis 6 Pages: 499-507
  • Peer Reviewed
• [Journal Article] Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans. (2008)
  • Author(s): 原田直明, 岡嶋研二, 栗原裕基, 中潟直巳
  • Journal Title: Growth Hormone & 1GF Research 18 Pages: 335-344
  • Peer Reviewed
• [Journal Article] Stimulation of sensory neurons by capsaicin increase tissue levels of IGF-I, thereby reducing reperfusion-induced apoptosis in mice (2007)
  • Author(s): 原田直明
  • Journal Title: Neuropharmacology 52 Pages: 1303-1311
  • Peer Reviewed
• [Journal Article] Danaparoid sodium reduces ischemia/reperfusion-induced liver injury in rats by attenuating inflammatory responses (2007)
  • Author(s): 原田直明
  • Journal Title: Thrombosis and Haemostasis 97 Pages: 81-87
  • Peer Reviewed
• [Journal Article] Effect of capsaicin on plasma and tissue levels of insulin-like growth factor-I in spontaneously hypertensive rats (2007)
  • Author(s): 原田直明
  • Journal Title: Growth Horm IGF Res 18 Pages: 75-81
  • Peer Reviewed
• [Journal Article] Stimulation of sensory neurons by capsaicin increase tissue levels of IGF-I, thereby reducing reperfusion-induced apoptosis in mice. (2007)
  • Author(s): Harada N
  • Journal Title: Neuropharmacology 52 Pages: 1303-1311
  • Peer Reviewed
• [Journal Article] Danaparoid sodium reduces ischemia/reperfusion-induced liver injury in rats by attenuating inflammatory responses (2007)
  • Author(s): Harada N
  • Journal Title: Thrombosis and Haemostasis 97 Pages: 81-87
  • Peer Reviewed
• [Journal Article] Effect of capsaicin on plasma and tissue levels of insulin-like growth factor-I in spontaneously hypertensive rats. (2007)
  • Author(s): Harada N
  • Journal Title: Growth Horm IGF Res 18 Pages: 75-81
  • Peer Reviewed
• [Presentation] Anti-inflammatory activity of immunoglobulins : involvement of interaction of FcgRI on sensory neurons (2008)
  • Author(s): 原田直明, 岡嶋研二
  • Organizer: 6th International Congress on Autoimmunity
  • Place of Presentation: Porto, Portugal
  • Year and Date: 2008-09-12
• [Presentation] Intravenous immunoglobulin reduces the ischemia/reperfusion-induced renal injury by increasing insulin-like growth factor-I production in mice (2008)
  • Author(s): 原田直明、岡嶋研二
  • Organizer: 28nd International Symposium on Intensive Care and Emergency Medicine
  • Place of Presentation: Brussels, Belgium
  • Year and Date: 2008-03-18
• [Presentation] Intravenous immunoglobulin reduces the ischemia/reperfusion-induced renal injury by increasing insulin-like growth factor-I production in mice (2008)
  • Author(s): Harada N
  • Organizer: 28th International Symposium on Intensive Care and Emergency Medicine
  • Place of Presentation: ベルギー国、ブリュッセル市
  • Year and Date: 2008-03-18
• [Book] Tanaka K, Davie EW (eds) Recent Advances in Thrombosis and Hemostasis (2008)
  • Author(s): 原田直明、岡嶋研二
  • Publisher: Springer Japan (Tokyo)、New aspects of anti-inflammatory activities of antithrombin-Molecular mechanism(s) and therapeutic implications-. In
• [Book] New aspects of anti-inflammatory activities of antithrombin-Molecular mechanism (s) and therapeutic implications-. In : Tanaka K, Davie EW (eds) Recent Advances in Thrombosis and Hemostasis. (2008)
  • Author(s): 原田直明, 岡嶋研二
  • Total Pages: 13
  • Publisher: Springer Japan (Tokyo)
• [Book] Xa阻害薬のすべて (2007)
  • Author(s): 原田直明
  • Publisher: 先端医学社
• [Book] Xa阻害薬のすべて (2007)
  • Author(s): 原田直明
  • Publisher: Xa阻害薬の炎症制御による臓器障害抑制を探る
• [Remarks]
  • URL: http://www.med.nagoya-cu.ac.jp/molbio.dir/