The role of phospholipase A2 in post-hemorrhagic shock mesenteric lymph on the development of distant organ injury.
| Project/Area Number |
19592101
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Nippon Medical School |
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Principal Investigator |
MASUNO Tomohiko Nippon Medical School, 医学部, 助教 (00318528)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Norio 日本医科大学, 医学部, 助教 (30409205)
YOKOTA Hiroyuki 日本医科大学, 医学研究科, 教授 (60182698)
鈴木 崇生 日本医科大学, 医学部, 助教 (40328810)
山本 保博 日本医科大学, 大学院・医学研究科, 教授 (70125079)
相星 淳一 東京医科歯科大学, 医学部附属病院, 講師 (50256913)
小池 薫 京都大学, 大学院・医学研究科, 教授 (10267164)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ショック / 腸管リンパ液 / 脂質メディエータ / 腸管虚血 / ホスホリパーゼA2 / 臓器障害 / 腸間膜リンパ / 出血性ショック |
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| Research Abstract |
The purpose of this study is to determine the role of phospholipase A2 in post-hemorrhagic shock mesenteric lymph (PSML) on the development of distant organ injury. Mesenteric ischemia increases or generates PLA2 protein in PSML. PLA_2 inhibition, in vitro and in vivo, attenuates the neutrophil priming effect of PSML and prevents acute lung injury in a two-event model.
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Report
(4 results)
Research Products
(8 results)
