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The role of phospholipase A2 in post-hemorrhagic shock mesenteric lymph on the development of distant organ injury.

Research Project

Project/Area Number 19592101
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionNippon Medical School

Principal Investigator

MASUNO Tomohiko  Nippon Medical School, 医学部, 助教 (00318528)

Co-Investigator(Kenkyū-buntansha) SATO Norio  日本医科大学, 医学部, 助教 (30409205)
YOKOTA Hiroyuki  日本医科大学, 医学研究科, 教授 (60182698)
鈴木 崇生  日本医科大学, 医学部, 助教 (40328810)
山本 保博  日本医科大学, 大学院・医学研究科, 教授 (70125079)
相星 淳一  東京医科歯科大学, 医学部附属病院, 講師 (50256913)
小池 薫  京都大学, 大学院・医学研究科, 教授 (10267164)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsショック / 腸管リンパ液 / 脂質メディエータ / 腸管虚血 / ホスホリパーゼA2 / 臓器障害 / 腸間膜リンパ / 出血性ショック
Research Abstract

The purpose of this study is to determine the role of phospholipase A2 in post-hemorrhagic shock mesenteric lymph (PSML) on the development of distant organ injury. Mesenteric ischemia increases or generates PLA2 protein in PSML. PLA_2 inhibition, in vitro and in vivo, attenuates the neutrophil priming effect of PSML and prevents acute lung injury in a two-event model.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report

Research Products

(8 results)

All 2009

All Journal Article (2 results) Presentation (6 results)

  • [Journal Article] 出血性ショック後に生じる臓器不全と腸管リンパ液の関与2009

    • Author(s)
      増野智彦
    • Journal Title

      生体と侵襲 18巻

      Pages: 19-28

    • Related Report
      2009 Final Research Report
  • [Journal Article] 出血性ショック後に生じる臓器不全と腸管リンパ液の関与2009

    • Author(s)
      増野智彦
    • Journal Title

      免疫と侵襲 18

      Pages: 19-28

    • Related Report
      2009 Annual Research Report
  • [Presentation] 出血性ショック後に生じる臓器不全と腸管リンパ液の関与2009

    • Author(s)
      増野智彦
    • Organizer
      Young Investigators Supporting Critical Care Conference
    • Place of Presentation
      千葉
    • Year and Date
      2009-06-27
    • Related Report
      2009 Final Research Report
  • [Presentation] 出血性ショック後に生じる臓器不全と 腸管リンパ液の関与2009

    • Author(s)
      増野智彦
    • Organizer
      Young Investigators Supporting Critical Care Conference
    • Place of Presentation
      千葉
    • Year and Date
      2009-06-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 出血性ショック後肺臓器は腸管リンパ液を介し発生する-IIa型ホスホリパーゼA2由来メディエーターの関与-2009

    • Author(s)
      増野智彦
    • Organizer
      第45回日本腹部救急医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-03-21
    • Related Report
      2009 Final Research Report
  • [Presentation] 出血性ショック後肺障害は腸管リンパ液を介し発生する-IIa型ホスホリパーゼA2由来メディェーターの関与-2009

    • Author(s)
      増野, 智彦
    • Organizer
      第45回日本腹部救急医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-03-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 出血性ショック後に生じる臓器不全と腸管リンパ液の関与2009

    • Author(s)
      増野智彦
    • Organizer
      第10回侵襲と生体反応研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-02-21
    • Related Report
      2009 Final Research Report
  • [Presentation] 出血性ショック後に生じる臓器不全と腸管リンパ液の関与2009

    • Author(s)
      増野, 智彦
    • Organizer
      第10回 侵襲と生体反応研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-02-21
    • Related Report
      2008 Annual Research Report

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Published: 2007-03-31   Modified: 2016-04-21  

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