The elucidation and the strategy for multiple organ dysfunction syndrome following severe burn injury.

• Project/Area Number: 19592102
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Nippon Medical School
• Principal Investigator: SATO Norio Nippon Medical School, 医学部, 助教 (30409205)
• Co-Investigator(Kenkyū-buntansha): MASUNO Tomohiko 日本医科大学, 医学部, 助教 (00318528) ; YOKOTA Hiroyuki 日本医科大学, 大学院・医学研究科, 教授 (60182698) ; 鈴木 崇生 日本医科大学, 医学部, 助教 (40328810) ; 山本 保博 日本医科大学, 大学院・医学研究科, 教授 (70125079) ; 相星 淳一 東京医科歯科大学, 医学部付属病院, 講師 (50256913) ; 小池 薫 京都大学, 大学院・医学研究科, 教授 (10267164)
• Research Collaborator: HIRAKAWA Keiko 日本医科大学, 医学部, 助教 (30165162) ; KOIKE Kaoru 京都大学, 大学院・医学研究科, 教授 (10267164) ; KOBAYASHI Tetsuyuki お茶の水女子大学, 大学院・人間文化創成科学研究科, 教授 (50178323)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 免疫調整栄養剤 / 脂肪酸代謝 / 腸管粘膜障害 / 腸上皮細胞 / n-3系脂肪酸 / 熱傷 / 栄養素 / 酸化ストレス / 臓器障害 / ω3系脂肪酸 / 腸粘膜 / 細菌感染症 / 多臓器障害 / 免疫栄養

Research Abstract

One of the major complications following severe burn is an infection.
This causes increasing high mortality rate and prolonged hospital stay. Early enteral nutrition is an important to preserve immune function and decrease complications. This study focused metabolism of fatty acids under inflammation using imunomodulating diets which usually is used clinically. First we investigated the basal experiment related with a continuous enteral nutrition of rat. Second we tested to change of metabolites following LPS stimulation as second hit after burned rat using 1H-NMR. We observed the different peak of metabolites between the groups.

Research Products

• [Presentation] 1H-NMR based metabolomics study of the intestinal epithelial cell Under oxidative stress (2010)
  • Author(s): 中田敬司
  • Organizer: Academic Surgical Congress
  • Place of Presentation: San Antonio
  • Year and Date: 2010-02-03
• [Presentation] 1H-NMR based metabolomics study of the intestinal epithelial cell (IEC-6) under the oxidative stress. (2010)
  • Author(s): K Nakata, N Sato, T. Asakura, K. Hirakawa, R Zhu, T Masuno, S Shiraishi, Y Ohno, K Koike, H Yokota.
  • Organizer: 5^<th> ASC (Academic Surgical Congress)
  • Place of Presentation: San Antonio, Texas USA
• [Presentation] Pattern recognition using 1H-NMR of the intestinal epithelial cell (IEC-6) under oxidative stress. (2010)
  • Author(s): K Nakara, N Sato, T Asakura, K Hirakawa, R Zhu, T Masuno, Y Ohno, K Koike, H Yokota.
  • Organizer: 33rd Shock Society.
  • Place of Presentation: Portland Oregon USA