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The effect of exercise training on circulatory shock with special reference on hepatic circulation

Research Project

Project/Area Number 19592103
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionKanazawa Medical University

Principal Investigator

MIYAMAE Shunichi  Kanazawa Medical University, 医学部, 講師 (30121263)

Co-Investigator(Kenkyū-buntansha) SHIBAMOTO Toshishige  金沢医科大学, 医学部, 教授 (90178921)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords救急蘇生学 / 循環ショック / 運動トレーニング / エンドトキシンショック / 出血性ショック / ラット / 肝循環 / 門脈圧 / 血管反応性 / アナフィラキシーショック / 摘出灌流肝臓 / 無麻酔
Research Abstract

運動トレーニングがアナフィラキシーショック、敗血症によるショックのモデルであるエンドトキシンショック、出血性ショックを軽減できるかどうか、ラット実験モデルで検討した。運動はトレッドミルで、速度10m/min、持続10分間から30m/min、30分間まで4週かけて漸増し負荷した。運動トレーニングはアナフィラキシー肝血管収縮を抑制したがアナフィラキシー低血圧は抑制しなかった。エンドトキシンショック、出血性ショックでは抑制効果はみられかった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (9 results)

All 2009 2008 2007 Other

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (2 results)

  • [Journal Article] Hepatic microvascular pressure during anaphylactic shock in anesthetized rats2009

    • Author(s)
      Takano H, Shibamoto T, Zhang W, Kurata Y, Toga H.
    • Journal Title

      Microvasc. Res 78(2)

      Pages: 169-173

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 7-nitroindazole, but not L-name or aminoguanidine, attenuates anaphylactic hypotension in conscious rats2009

    • Author(s)
      Zhang W, Shibamoto T, Cui S, Takano H, Kurata Y.
    • Journal Title

      Shock 31(2)

      Pages: 201-6

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 7-Nitroindazole, but not L-NAME or aminoguanidine, attenuates anaphylactic hypotension in conscious rats.2009

    • Author(s)
      Zhang W
    • Journal Title

      Shock 31(2)

      Pages: 201-206

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The roles of mast cells and Kupffer cells in rat systemic anaphylaxis2007

    • Author(s)
      Shibamoto T, Shimo T, Cui S, Zhang W, Takano H, Kurata Y, Tsuchida H.
    • Journal Title

      Am. J. Physiol. Regul. Integr. Comp. Physiol. 293(6)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The roles of mast cells and Kupffer cells in rat systemic anaphylaxis.2007

    • Author(s)
      Shibamoto T.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol. 293(6)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exercise training attenuates anaphylactic venoconstriction in perfused rat livers, but does not affect anaphylactic hypotension in conscious rats.

    • Author(s)
      Cui S, Shibamoto T, Zhang W, Kurata Y, Kashimura O, Miyamae S.
    • Journal Title

      Clin. Exp. Pharmacol. Physiol. (in press)

    • Related Report
      2008 Final Research Report
  • [Journal Article] Liver volume, as assessed by four ultrasonic crystals arranged to form a tetrahedron, decreases during anaphylactic shock in anesthetized rats

    • Author(s)
      Takano H, Shibamoto T, Zhang W, Kurata Y.
    • Journal Title

      Shock (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] 運動トレーニングのラットアナフィラキシーショックへ及ぼす影響2009

    • Author(s)
      張偉, 芝本利重, 宮前俊一, 倉田康孝
    • Organizer
      第56回中部日本生理学会
    • Place of Presentation
      石川県金沢市
    • Year and Date
      2009-12-04
    • Related Report
      2008 Final Research Report
  • [Presentation] The role of nitric oxide in anaphylactic shock in conscious rats2008

    • Author(s)
      Wei Zhang, Toshishige Shibamoto, Sen Cui, Hiromichi Takano, Yasutaka Kurata
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京都新宿
    • Year and Date
      2008-03-27
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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