Loss of heterozygosity analysis and its relationship with Clinicopathological features in ameloblastoma

• Project/Area Number: 19592109
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Okayama University
• Principal Investigator: NAGATSUKA Hitoshi Okayama University, 大学院・医歯薬学総合研究科, 准教授 (70237535)
• Co-Investigator(Kenkyū-buntansha): NAGAI Noriyuki 岡山大学, 名誉教授 (90085770) ; MEMETUTO Gundeuzu 岡山大学, 大学院・医歯薬学総合研究科, 助教 (70333507) ; TUJIGIWA Hidetugu 岡山大学, 大学院・医歯薬学総合研究科, 助教 (70335628) ; TAMAMURA Ryo 岡山大学, 大学院・医歯薬学総合研究科, 助教 (00403494)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 歯原性腫瘍 / エナメル上皮腫 / 遺伝子解析 / ヘテロ接合性 / LOH解析癌抑制遺伝子 / INGファミリー / LOH解析 / 癌抑制遺伝子

Research Abstract

腫瘍の発生には癌関連遺伝子の遺伝的変化が重要であることが知られている。本研究では、代表的な歯原性腫瘍であり、いまだ決定的治療法のないエナメル上皮腫について、腫瘍特異的な癌抑制遺伝子の同定と解析を目的とし、ヘテロ接合性消失解析による広範な遺伝子レベルでの検索を行った。結果からは、エナメル上皮腫瘍の再発や顎骨侵襲性に関連する癌抑制遺伝子の存在が示唆され、同腫瘍の特異性を解明する一助となる成果が見られた。

Research Products

• [Journal Article] Frequent deletion of ING2 locus at 4q35. 1 associates with advanced tumor stage in head and neck squamous cell carcinoma (2009)
  • Author(s): Borkosky, SS, Gunduz, M, Nagatsuka, H, Beder, LB, Gunduz, E, AI, Sheikh, Ali, M, Rodriguez, AP, Cilek, MZ, Tominaga, S, Yamanaka, N, Shimizu, K, Nagai, N
  • Journal Title: J Cancer Res Clin Oncol 135巻5号 Pages: 703-713
  • Peer Reviewed
• [Journal Article] Downregulation of TESTIN and its association with cancer history and a tendency toward poor survival in head and neck squamous cell carcinoma. (2009)
  • Author(s): Gunduz E
  • Journal Title: Arch Otolaryngol Head Neck Sure. 135(3) Pages: 254-260
  • Peer Reviewed
• [Journal Article] Fine deletion analysis of 1p36 chromosomal region in oral squamous cell carcinomas. (2009)
  • Author(s): Lefeuvre M
  • Journal Title: J Oral Pathol Med. 38(1) Pages: 94-98
  • Peer Reviewed
• [Journal Article] Fine deletion analysis of 1p36 chromosomal region in oral squamous cell carcinomas (2008)
  • Author(s): Lefeuvre M, Gunduz M, Nagatsuka H, Gunduz E, Al Sheikh Ali M, Beder L, Fukushima K, Yamanaka N, Shimizu K, Nagai N
  • Journal Title: J Oral Pathol Med 38巻1号 Pages: 94-98
  • Peer Reviewed
• [Journal Article] Deletion at Dickkopf (dkk)-3 locus (11p15. 2) is related with lower lymph node metastasis and better prognosis in head and neck squamous cell carcinomas (2008)
  • Author(s): Katase N, Gunduz M, Beder L, Gunduz E, Lefeuvre M, Hatipoglu OF, Borkosky SS, Tamamura R, Tominaga S, Yamanaka N, Shimizu K, Nagai N, Nagatsuka H
  • Journal Title: Oncol Res 17巻6号 Pages: 273-282
  • Peer Reviewed
• [Journal Article] Sequential expressions of Notchl, Jagged2 and Mathl in molar tooth germ of mouse (2008)
  • Author(s): Borkosky SS, Nagatsuka H, Orita Y, Tsujigiwa H, Yoshinobu J, Gunduz M, Rodriguez AP, Missana LR, Nishizaki K, Nagai N,
  • Journal Title: Biocell 32巻3号 Pages: 251-258
  • Peer Reviewed
• [Journal Article] Lack of B-RAF mutations in head and neck squamous cell carcinoma (2008)
  • Author(s): Al Sheikh Ali M, Gunduz M, Gunduz E, Tamamura R, Beder L, Tominaga S, Onoda T, Yamanaka N, Grenman R, Shimizu K, Nagai N, Nagatsuka H
  • Journal Title: Folia Biol (Praha) 54巻5号 Pages: 157-161
  • Peer Reviewed
• [Journal Article] Notch signaling in benign and malignant ameloblastic neoplasms (2008)
  • Author(s): Nakano K, Siar CH, Tsujigiwa H, Nagatsuka H, Nagai N, Kawakami T
  • Journal Title: Eur J Med Res 13巻10号 Pages: 476-480
  • Peer Reviewed
• [Journal Article] Stromal cells promote bone invasion by suppressing bone formation in ameloblastoma (2008)
  • Author(s): Sathi GSA, Nagatsuka H, Tamamura R, Fujii M, Gunduz M, Inoue M, Rivera RS, Nagai N
  • Journal Title: Histopathology 53巻 Pages: 458-467
  • Peer Reviewed
• [Journal Article] Expression and mutation analysis of epidermal growth factor receptor in head and neck squamous cell carcinoma (2008)
  • Author(s): Sheikh Ali MA, Gunduz M, Nagatsuka H, Gunduz E, Cengiz B, Fukushima K, Beder LB, Demircan K, Fujii M, Yamanaka N, Shimizu K, Grenman R, Nagai N
  • Journal Title: Cancer Sci 99巻8号 Pages: 1589-1594
  • NAID: 10024009803
  • Peer Reviewed
• [Journal Article] The inhibitor of growth (ING) gene family : potential role in cancer therapy (2008)
  • Author(s): Gunduz M, Gunduz E, Rivera RS, Nagatsuka H
  • Journal Title: Curr Cancer Drug Targets 8巻4号 Pages: 275-284
  • Peer Reviewed
• [Journal Article] Downregulation of ING3 mRNA expression predicts poor prognosis in head and neck cancer (2008)
  • Author(s): Gunduz M, Beder LB, Gunduz E, NagatsukaH, Fukushima K, Pehlivan D, Cetin E, Yamanaka N, Nishizaki K, Shimizu K, Nagai N
  • Journal Title: Cancer Sci 99巻3号 Pages: 531-538
  • NAID: 10024003741
  • Peer Reviewed
• [Journal Article] Deletion mapping of chromosome 4q22-35 and identification of four frequently deleted regions in head and neck cancers (2008)
  • Author(s): Cetin E, Cengiz B, Gunduz E, Gunduz M, Nagatsuka H, Bekir-Beder L, Fukushima K, Pehlivan D, N MO, Nishizaki K, Shimizu K, Nagai N
  • Journal Title: Neoplasma 55巻4号 Pages: 299-304
  • Peer Reviewed
• [Journal Article] Involvement of EphA2 in head and neck squamous cell carcinoma : mRNA expression, loss of heterozygosity and immunohistochemical studies (2008)
  • Author(s): Rivera RS, Gunduz M, Nagatsuka H, Gunduz E, Cengiz B, Fukushima K, Beder LB, Pehlivan D, Yamanaka N, Shimizu K, Nagai N
  • Journal Title: Oncol Rep 19巻5号 Pages: 1079-1084
  • Peer Reviewed
• [Journal Article] Inhibitor of growth (ING) family : An emerging molecular target for cancer therapy (2008)
  • Author(s): Gunduz E, Gunduz M, Beder LB, Tamamura R, Nagatsuka H, Nagai N
  • Journal Title: Journal of Hard Tissue Biology 17巻1号 Pages: 1-10
  • NAID: 110006791909
  • Peer Reviewed
• [Journal Article] Deletion at Dickkopf (dkk)-3 locus (11p15. 2)is related with lower lymph node metastasis and better prognosis in head and neck squamous cell carcinomas. (2008)
  • Author(s): Katase N
  • Journal Title: Oncol Res. 17(6) Pages: 273-282
  • Peer Reviewed
• [Journal Article] Sequential expressions of Notch1, Jagged2 and Math1 in molar tooth germ of mouse. (2008)
  • Author(s): Borkosky ss
  • Journal Title: Bioce11. 32(3) Pages: 251-258
  • Peer Reviewed
• [Journal Article] Lack of B-RAF mutations in head and neck squamous cell carcinoma. (2008)
  • Author(s): Al Sheikh Ali M
  • Journal Title: Folia Biol(Praha). 54(5) Pages: 157-161
  • Peer Reviewed
• [Journal Article] Notch signaling in benign and malignant ameloblastic neoplasms. (2008)
  • Author(s): Nakano K
  • Journal Title: Eur J Med Res. 13(10) Pages: 476-480
  • Peer Reviewed
• [Journal Article] Stromal cells promote bone invasion by suppressing bone formation in ameloblastoma. (2008)
  • Author(s): Sathi GSA
  • Journal Title: Histopathology. 53 Pages: 458-467
  • Peer Reviewed
• [Journal Article] Expression and mutation analysis of epidermal growth factor receptor in head and neck squamous cell carcinoma. (2008)
  • Author(s): AlSheikh Ali M
  • Journal Title: Cancer Sci. 99(8) Pages: 1589-1594
  • Peer Reviewed
• [Journal Article] The inhibitor of growth (ING)gene family : potential role in cancertherapy. (2008)
  • Author(s): Gunduz M
  • Journal Title: Curr Cancer Drug Targets. 8(4) Pages: 275-284
  • Peer Reviewed
• [Journal Article] Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas. (2008)
  • Author(s): Pehlivan D
  • Journal Title: J Cancer Res Clin Oncol. 134(12) Pages: 1267-1276
  • Peer Reviewed
• [Journal Article] Deletion mapping of chromosome 4q22-35 and identification of four frequently deleted regions in head and neck cancers. (2008)
  • Author(s): Cetin E
  • Journal Title: Neoplasma. 55(4) Pages: 299-304
  • Peer Reviewed
• [Journal Article] Involvement of EphA2 in head and neck squamous cell carcinoma : mRNA exspression, loss of heterozygos ity and immunohistochemical studies. (2008)
  • Author(s): Rivera RS
  • Journal Title: Oncol Rep. 19(5) Pages: 1079-1084
  • Peer Reviewed
• [Journal Article] A study of recurrent giant odontogenic myxoma of the mandible with immunohistochemical examination of Notch. (2008)
  • Author(s): Nakano K
  • Journal Title: Oral Medicine & Pathology. 12(2) Pages: 53-56
  • Peer Reviewed
• [Journal Article] Inhibitor of growth(ING)family : An emerging molecular target for cancer therapy. (2008)
  • Author(s): Gunduz E
  • Journal Title: Journal of Hard Tissue Biology. 17(1) Pages: 1-10
  • Peer Reviewed
• [Journal Article] Localization of oxytalan fiber, type III collagen and BMP family in conventional and desmoplastic ameloblastoma. (2008)
  • Author(s): Inoue M
  • Journal Title: Journal of Hard Tissue Biology. 17(1) Pages: 23-30
  • Peer Reviewed
• [Journal Article] Juxta-Epithelial Hyalinization Inhibits Tumor Growth and Invasion in Ameloblastoma. (2008)
  • Author(s): Sathi GSA
  • Journal Title: Journal of Hard Tissue Biology. 17(2) Pages: 63-68
  • Peer Reviewed
• [Journal Article] Immunohistochemical Characteristics of Odontogenic Neoplasms and Their Physiological Counterparts. (2008)
  • Author(s): Nakano K
  • Journal Title: Journal of Hard Tissue Biology. 17(3) Pages: 79-90
  • Peer Reviewed
• [Journal Article] Gene expression of jagged2 in mandibular condylar cartilage development. (2008)
  • Author(s): Shimizu T
  • Journal Title: Eur J Med Res 13(1) Pages: 1-3
  • Peer Reviewed
• [Journal Article] Downregulation of ING3 mRNA expression predicts poor prognosis in head and neck cancer. (2008)
  • Author(s): Gunduz M
  • Journal Title: Cancer Sci 99(3) Pages: 531-8
  • Peer Reviewed
• [Journal Article] C-kit protein expression correlated with activating mutations in KIT gene in oral mucosal melanoma. (2008)
  • Author(s): Rivera RS
  • Journal Title: Virchows Arch 452(1) Pages: 27-32
  • Peer Reviewed
• [Journal Article] Fine deletion mapping of chromosome 2q21-37 shows three preferentially deleted regions in oral cancer (2007)
  • Author(s): Cengiz B, Gunduz M, Nagatsuka H, Beder L, Gunduz E, Tamamura R, Mahmut N, Fukushima K, Ali MA, Naomoto Y, Shimizu K, Nagai N
  • Journal Title: Oral Oncol 43巻3号 Pages: 241-247
  • Peer Reviewed
• [Journal Article] Notch signaling in mandibular condylar cartilage development. (2007)
  • Author(s): Shimizu T
  • Journal Title: Eur J Med Res 12(10) Pages: 515-9
  • Peer Reviewed
• [Journal Article] Immunolocalization of cell signaling molecules in the granular cell ameloblastoma. (2007)
  • Author(s): Sathi GS
  • Journal Title: J Oral Pathol Med 36(10) Pages: 609-14
  • Peer Reviewed
• [Journal Article] Analysis of the neoplastic nature and biological potential of sporadic and nevoid basal cell carcinoma syndrome-associated keratocystic odontogenic tumor. (2007)
  • Author(s): Katase N
  • Journal Title: J Oral Pathol Med 36(9) Pages: 550-4
  • Peer Reviewed
• [Journal Article] Comprehensive loss of heterozygosity analysis and identification of a novel hotspot at 3p21 in salivary gland neoplasms. (2007)
  • Author(s): Honjo N
  • Journal Title: Otolaryngol Head Neck Surg 137(1) Pages: 119-25
  • Peer Reviewed
• [Journal Article] Depletion of O6-methylguanine-DNA methyltransferase by O6-benzylguanine enhances 5-FU cytotoxicity in colon and oral cancer cell lines. (2007)
  • Author(s): Murakami J
  • Journal Title: Oncol Rep 17(6) Pages: 1461-7
  • Peer Reviewed
• [Journal Article] Heparanase promotes angiogenesis through Cox-2 and HIFlalpha. (2007)
  • Author(s): Naomoto Y
  • Journal Title: Med Hypotheses 68(1) Pages: 162-5
  • Peer Reviewed
• [Journal Article] Translocation of heparanase into nucleus results in cell differentiation. (2007)
  • Author(s): Nobuhisa T
  • Journal Title: Cancer Sci 98(4) Pages: 535-40
  • Peer Reviewed
• [Journal Article] An immunohistochemical evaluation of BMP-2, -4, osteopontin, osteocalcin and PCNA between ossifying fibromas of the jaws and peripheral cemento-ossifying fibromas on the gingiva. (2007)
  • Author(s): Ono A
  • Journal Title: Oral Oncol 43(4) Pages: 339-44
  • Peer Reviewed
• [Journal Article] Effects of a novel palatinose based enteral formula (MHN-01) carbohydrate-adjusted fluid diet in improving the metabolism of carbohydrates and lipids in patients with esophageal cancer complicated by diabetes mellitus. (2007)
  • Author(s): Fujiwara T
  • Journal Title: J Surg Res 138(2) Pages: 231-40
  • Peer Reviewed
• [Journal Article] Role of Heparanase in the Release of Heparan Sulphate Binding Growth Factors in Odontogenic Tumors. (2007)
  • Author(s): Phuu Pwint Han
  • Journal Title: J Hard Tissue Biology 16(1) Pages: 23-30
  • Peer Reviewed
• [Journal Article] Characterization and Gene Expression Profiling of Human Mesenchymal Stem Cells. (2007)
  • Author(s): Hiroki Mori
  • Journal Title: J Hard Tissue Biology 16(1) Pages: 36-41
  • Peer Reviewed
• [Journal Article] Origin of Osteoblasts Involved in the Mechanisn of Ectopic Bone Formation Induced by KUSA/A1 Cells with Honeycomb Carrier. (2007)
  • Author(s): Rodriguez Andrea P
  • Journal Title: J Hard Tissue Biology 16(2) Pages: 75-8
  • Peer Reviewed
• [Journal Article] Wnt5a Overexpression in Thick Primary Oral Mucosal Melanomas: Implications for its Role in Tumor Progression. (2007)
  • Author(s): Jing Xiao
  • Journal Title: J Hard Tissue Biology 16(2) Pages: 79-86
  • Peer Reviewed
• [Journal Article] The Study of Palatal Cell Proliferation and Apoptosis in Retinoic Acid Induced Mouse Cleft Palate Varied with Different Developmental Stage. (2007)
  • Author(s): Jing Xiao
  • Journal Title: J Hard Tissue Biology 16(3) Pages: 125-30
  • Peer Reviewed
• [Journal Article] A pigmented calcifying cystic odontogenic tumor associated with compound odontoma: a case report and review of literature. (2007)
  • Author(s): Han PP
  • Journal Title: Head Face Med 3:35(online)
  • Peer Reviewed
• [Journal Article] Biological Analysis of a Candidate Stem Cell-KUSA/A1 cell-for Bone Tissue Engineering. (2007)
  • Author(s): Andrea P. Rodriguez
  • Journal Title: J Hard Tissue Biology 16(1) Pages: 1-14
  • Peer Reviewed
• [Presentation] Role of Tumor-Stromal Cells Interaction in Bone Resorption in Ameloblastoma (2008)
  • Author(s): Sathi GSA
  • Organizer: 第29回岡山歯学会
  • Place of Presentation: 岡山
  • Year and Date: 2008-11-24
• [Presentation] Microsatellite analysis of the ING tumor suppressor genes and relationship with clinicopathological features in ameloblastoma (2008)
  • Author(s): Borkosky ss
  • Organizer: 第29回岡山歯学会
  • Place of Presentation: 岡山
  • Year and Date: 2008-11-24
• [Presentation] Analysis of the epidermal growth factor receptor and related signaling molecules in head and neck squamous cell carcinoma (2008)
  • Author(s): Al Sheikh All M
  • Organizer: 第29回岡山歯学会
  • Place of Presentation: 岡山
  • Year and Date: 2008-11-24
• [Presentation] Examination of loss of heterozygosity in 1p36 chromosomal region in oral squamous cell carcinoma (2008)
  • Author(s): Lefeuvre Mathieu
  • Organizer: 第50回歯科基礎医学会
  • Place of Presentation: 東京
  • Year and Date: 2008-09-23
• [Presentation] Microsatellite analysis of ING tumor suppressor genes in ameloblastoma (2008)
  • Author(s): Silvia Susana Borkosky
  • Organizer: 第17回硬組織再生生物学会
  • Place of Presentation: 徳島
  • Year and Date: 2008-08-30
• [Presentation] Stromal Cells Promote Bone Invasion by Suppressing BoneFormation in Ameloblastoma (2008)
  • Author(s): Gul San Ara Sathi
  • Organizer: 第17回硬組織再生生物学会
  • Place of Presentation: 徳島
  • Year and Date: 2008-08-30
• [Presentation] Stromal Cells Promote Bone Invasion by Suppressing Bone Formation in Ameloblastoma (2008)
  • Author(s): Sathi GSA
  • Organizer: 第19回日本臨床口腔病理学会
  • Place of Presentation: 徳島
  • Year and Date: 2008-08-30
• [Presentation] 下顎に再発した巨大な歯原性粘液腫の1症例-Notchの免疫組織化学的検討- (2008)
  • Author(s): 中野敬介
  • Organizer: 第19回日本臨床口腔病理学会
  • Place of Presentation: 東京
  • Year and Date: 2008-08-22
• [Presentation] Expression and mutation analysis of epidermal growth factor receptor(EGFR)in head and neck squamous cell carcinoma (2008)
  • Author(s): Al Sheikh All M
  • Organizer: 第19回日本臨床口腔病理学会
  • Place of Presentation: 東京
  • Year and Date: 2008-08-22
• [Presentation] 上顎歯肉腫瘍 (2008)
  • Author(s): 片瀬直樹
  • Organizer: 第19回日本臨床口腔病理学会
  • Place of Presentation: 東京
  • Year and Date: 2008-08-21
• [Presentation] Expression and mutation analysis of epidermal growth factor receptor (EGER) in head and neck squamouscellcarcinoma (2008)
  • Author(s): Mahmoud Al Sheikh Ali
  • Organizer: 第19回日本臨床口腔病理学会
  • Place of Presentation: 東京
  • Year and Date: 2008-08-20
• [Presentation] CLINICAL SIGNIFICANCE OF TESTIN EXPRESSION IN HEAD AND NECK SQUAMOUS CELL CARCINOMAS (2008)
  • Author(s): Gunduz M
  • Organizer: 7th International Conference on Head and Neck Cancer
  • Place of Presentation: San Francisco
  • Year and Date: 2008-07-20
• [Presentation] SOMATIC MUTATIONS IN C-KIT, NRAS AND BRAF IN ORAL MUCOSAL MELANOMA (2008)
  • Author(s): Rivera R
  • Organizer: The 14^<th> International Congress of Oral Pathology and Medicine (IAOP)
  • Place of Presentation: San Francisco
  • Year and Date: 2008-06-26
• [Presentation] 頭頭部扁平上皮癌におけるDkk遺伝子ファミリーのLOH解析 (2008)
  • Author(s): 片瀬直樹
  • Organizer: 第9 7回日本病理学会
  • Place of Presentation: 石川
  • Year and Date: 2008-05-16
• [Presentation] Ameloblastomaとameloblastic carcinomaにおけるNotchの発現 (2008)
  • Author(s): 中野敬介
  • Organizer: 第9 7回日本病理学会
  • Place of Presentation: 石川
  • Year and Date: 2008-05-16
• [Presentation] エナメル上皮腫間質細胞における骨吸収因子の免疫組織化学的検討 (2008)
  • Author(s): 玉村亮
  • Organizer: 第9 7回日本病理学会
  • Place of Presentation: 石川
  • Year and Date: 2008-05-16
• [Presentation] 口腔悪性黒色腫におけるKIT遺伝子機能獲得型突然変異とc-kit蛋白発現 (2008)
  • Author(s): 長塚仁
  • Organizer: 第9 7回日本病理学会
  • Place of Presentation: 石川
  • Year and Date: 2008-05-16
• [Presentation] 頭頸部扁平上皮癌におけるDkk遺伝子ファミリーのLOH解析 (2008)
  • Author(s): 片瀬直樹
  • Organizer: 第97回日本病理学会
  • Place of Presentation: 金沢
  • Year and Date: 2008-05-15
• [Presentation] エナメル上皮腫問質細胞における骨吸収因子の免疫組織化学的検討 (2008)
  • Author(s): 玉村亮
  • Organizer: 第97回日本病理学会
  • Place of Presentation: 金沢
  • Year and Date: 2008-05-15
• [Presentation] 頭頸部扁平上皮癌における転移抑制遺伝子候補遺伝子に関する研究 (2008)
  • Author(s): Beder, Levent
  • Organizer: 第26回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 大阪
  • Year and Date: 2008-02-21
• [Presentation] Clinicopathological Evaluation of Oral Mucosal Melanoma. (2007)
  • Author(s): Rivera RS
  • Organizer: 2nd International Working Group Meeting on Tropical Oral Health
  • Place of Presentation: Okayama
  • Year and Date: 2007-11-02
• [Presentation] Molecular Analysis of ING3 andING4 and Their Prognostic Role in HeadandNeck Cancers (2007)
  • Author(s): Gunduz, E
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-03
• [Presentation] シェーグレン症候群の進行と口唇腺中のヒトβデフェンシンの発現様式との関係 (2007)
  • Author(s): 金田祥弘
  • Organizer: 第52回日本口腔外科学会総会・学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-09-29
• [Presentation] A basic research of CaTiO3-C as a coating material for implants (2007)
  • Author(s): 胡 海龍
  • Organizer: 第16回硬組織再生生物学会
  • Place of Presentation: 長野
  • Year and Date: 2007-09-22
• [Presentation] 新規生体材料(チタン酸カルシウム-非晶質炭素複合物CaTiO3-C)の細胞学的検討 (2007)
  • Author(s): 井上美穂
  • Organizer: 第16回硬組織再生生物学会
  • Place of Presentation: 長野
  • Year and Date: 2007-09-22
• [Presentation] 間接リウマチ滑膜細胞におけるクラスター分化抗原CD81の役`割 (2007)
  • Author(s): 森宏樹
  • Organizer: 第16回硬組織再生生物学会
  • Place of Presentation: 長野
  • Year and Date: 2007-09-22
• [Presentation] Biological analysis of a candidate stem cell-KUSA/A1 cell-for bone tissue engineering. (2007)
  • Author(s): Rodriguez Andrea Paola
  • Organizer: 第16回硬組織再生生物学会
  • Place of Presentation: 長野
  • Year and Date: 2007-09-22
• [Presentation] 骨髄由来間葉系幹細胞の歯牙構成細胞への分化能についての検討 (2007)
  • Author(s): 辻極秀次
  • Organizer: 第16回硬組織再生生物学会
  • Place of Presentation: 長野
  • Year and Date: 2007-09-22
• [Presentation] 歯原性腫瘍の悪性変化とNotchシグナリング (2007)
  • Author(s): 中野敬介
  • Organizer: 第16回硬組織再生生物学会
  • Place of Presentation: 長野
  • Year and Date: 2007-09-22
• [Presentation] 下顎頭軟骨の発生におけるNotchシグナルの出現 (2007)
  • Author(s): 清水貴子
  • Organizer: 第16回硬組織再生生物学会
  • Place of Presentation: 長野
  • Year and Date: 2007-09-22
• [Presentation] 頭頸部癌における癌抑制遺伝子ファミリー新規メンバーING3及びING4の分子生物学的解析 (2007)
  • Author(s): グンデゥズエスラ
  • Organizer: 第49回歯科基礎医学会
  • Place of Presentation: 札幌
  • Year and Date: 2007-08-31
• [Presentation] 頭頸部癌におけるEGFRシグナル経路の分子生物学及び組織病理的解析 (2007)
  • Author(s): グンデゥズメーメット
  • Organizer: 第49回歯科基礎医学会
  • Place of Presentation: 札幌
  • Year and Date: 2007-08-31
• [Presentation] Ameloblastomaの悪性変化におけるNotchシグナルの関与 (2007)
  • Author(s): 中野敬介
  • Organizer: 第49回歯科基礎医学会学術大会ならびに総会
  • Place of Presentation: 北海造
  • Year and Date: 2007-08-31
• [Presentation] 頭頸部癌におけるEGFRシグナル経路の分子生物学及び組織病理的解析 (2007)
  • Author(s): グンデゥズ メーメット
  • Organizer: 第49回歯科基礎医学会学術大会ならびに総会
  • Place of Presentation: 北海道
  • Year and Date: 2007-08-31
• [Presentation] 頭頸部癌における癌抑制遺伝子ファミリー新規メンバーING3及びING4の分子生物学的解析 (2007)
  • Author(s): グンデゥズ エスラ
  • Organizer: 第49回歯科基礎医学会学術大会ならびに総会
  • Place of Presentation: 北海道
  • Year and Date: 2007-08-31
• [Presentation] インプラントコーティング材としてのチタン酸カルシウム-非晶質炭素複合物(CaTiO3-C)の基礎的研究 (2007)
  • Author(s): 岡内美佳
  • Organizer: 第49回歯科基礎医学会学術大会ならびに総会
  • Place of Presentation: 北海道
  • Year and Date: 2007-08-30
• [Presentation] NOTCH SIGNALINGによる下顎軟骨発生の調節 (2007)
  • Author(s): 清水貴子
  • Organizer: 第49回歯科基礎医学会学術大会ならびに総会
  • Place of Presentation: 北海道
  • Year and Date: 2007-08-30
• [Presentation] 顆粒細胞型エナメル上皮腫におけるシグナル分子の免疫組織化学的検討 (2007)
  • Author(s): 玉村亮
  • Organizer: 第18回日本口腔病理学会総会・学術大会
  • Place of Presentation: 岐阜
  • Year and Date: 2007-08-11
• [Presentation] 下顎歯肉腫瘍 (2007)
  • Author(s): 片瀬直樹
  • Organizer: 第18回日本口腔病理学会総会・学術大会
  • Place of Presentation: 岐阜
  • Year and Date: 2007-08-10
• [Presentation] Down-regulation of ING3 mRNA Expression Predicts Poor Prognosis inHeadandNeckcancer (2007)
  • Author(s): Beder, Levent
  • Organizer: 第31回日本頭頸部癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-06-13
• [Presentation] Tumor suppressor genes, Oncogenes and gene therapy in cancer (2007)
  • Author(s): Gunduz, Mehmet
  • Organizer: 2nd Agean Pharmacogenomics meeting
  • Place of Presentation: Isparta, Turkey
  • Year and Date: 2007-05-25
• [Presentation] Single nucleotide polymorphisms and individualized therapy (2007)
  • Author(s): Gunduz, Mehmet
  • Organizer: 2nd Agean Pharmacogenomics meeting
  • Place of Presentation: Isparta, Turkey
  • Year and Date: 2007-05-25
• [Presentation] The Role of EGFR Pathway in Head and Neck Squamous Cell Carcinomas (2007)
  • Author(s): Gunduz, M
  • Organizer: 第98回AACR
  • Place of Presentation: Los Angeles, USA
  • Year and Date: 2007-04-14
• [Presentation] Molecular analysis of ING4 and its splicing variants in oral cancer (2007)
  • Author(s): Gunduz, E
  • Organizer: 第98回AACR
  • Place of Presentation: Los Angeles, USA
  • Year and Date: 2007-04-14
• [Presentation] 頭頸部癌における転移抑制遺伝子候補のmRNA発現の解析 (2007)
  • Author(s): 福島邦博
  • Organizer: 第31回日本頭頸部癌学会・第28回頭頸部手術手技研究会
  • Place of Presentation: 横浜
• [Presentation] 耳下腺腫瘍におけるヘテロ接合性の消失の検討 (2007)
  • Author(s): 小野田友男
  • Organizer: 第31回日本頭頸部癌学会・第28回頭頸部手術手技研究会
  • Place of Presentation: 横浜
• [Presentation] Down-regulation of ING3 mRNA Expression Predicts Poor Prognosis in Head and Neck cancer. (2007)
  • Author(s): Beder Levent
  • Organizer: 第31回日本頭頸部癌学会・第28回頭頸部手術手技研究会
  • Place of Presentation: 横浜
• [Presentation] Molecular analysis of EGFR-Ras-Raf pathway in head and neck cancer. (2007)
  • Author(s): Gunduz Mehmet
  • Organizer: 第31回日本頭頸部癌学会・第28回頭頸部手術手技研究会
  • Place of Presentation: 横浜
• [Presentation] Molecular and Histopathological Analysis of the EGFR-Ras-Raf Pathway in Head and Neck Squamous Cell Carcinomas. (2007)
  • Author(s): Gunduz M
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Molecular Analysis of ING3 and ING4 and Their Prognostic Role in Head and Neck Cancers. (2007)
  • Author(s): Gunduz E
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] mRNA expression analysis of ADAM-TS-aggrecanases in head and neck cancers. (2007)
  • Author(s): Demircan K
  • Organizer: 98th annual meeting of AACR
  • Place of Presentation: Los Angeles
• [Presentation] Molecular analysis of ING4 and its splicing variants in oral cancer. (2007)
  • Author(s): Gunduz E
  • Organizer: 98th annual meeting of AACR
  • Place of Presentation: Los Angeles
• [Presentation] The Role of EGFR Pathway in Head and Neck Squamous Cell Carcinomas. (2007)
  • Author(s): Gunduz M
  • Organizer: 98th annual meeting of AACR
  • Place of Presentation: Los Angeles
• [Presentation] Tumor suppressor genes, Oncogenes and gene therapy in cancer. (2007)
  • Author(s): Gunduz Mehmet
  • Organizer: 2nd Agean Pharmacogenomics meeting
  • Place of Presentation: Isparta, Turkey
• [Presentation] Single nucleotide polymorphisms and individualized therapy. (2007)
  • Author(s): Gunduz Mehmet
  • Organizer: 2nd Agean Pharmacogenomics meeting
  • Place of Presentation: Isparta, Turkey
• [Presentation] Role of Metastasis Supressor Genes in Head and Neck Squamous Cell Carcinomas. (2007)
  • Author(s): Beder L
  • Organizer: 108th Meeting of the Oto-Rhino-Laryngological Society of Japan
  • Place of Presentation: Kanazawa