Loss of heterozygosity analysis and its relationship with Clinicopathological features in ameloblastoma
Project/Area Number |
19592109
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Morphological basic dentistry
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Research Institution | Okayama University |
Principal Investigator |
NAGATSUKA Hitoshi Okayama University, 大学院・医歯薬学総合研究科, 准教授 (70237535)
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Co-Investigator(Kenkyū-buntansha) |
NAGAI Noriyuki 岡山大学, 名誉教授 (90085770)
MEMETUTO Gundeuzu 岡山大学, 大学院・医歯薬学総合研究科, 助教 (70333507)
TUJIGIWA Hidetugu 岡山大学, 大学院・医歯薬学総合研究科, 助教 (70335628)
TAMAMURA Ryo 岡山大学, 大学院・医歯薬学総合研究科, 助教 (00403494)
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Project Period (FY) |
2007 – 2008
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Project Status |
Completed (Fiscal Year 2008)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | 歯原性腫瘍 / エナメル上皮腫 / 遺伝子解析 / ヘテロ接合性 / LOH解析癌抑制遺伝子 / INGファミリー / LOH解析 / 癌抑制遺伝子 |
Research Abstract |
腫瘍の発生には癌関連遺伝子の遺伝的変化が重要であることが知られている。本研究では、代表的な歯原性腫瘍であり、いまだ決定的治療法のないエナメル上皮腫について、腫瘍特異的な癌抑制遺伝子の同定と解析を目的とし、ヘテロ接合性消失解析による広範な遺伝子レベルでの検索を行った。結果からは、エナメル上皮腫瘍の再発や顎骨侵襲性に関連する癌抑制遺伝子の存在が示唆され、同腫瘍の特異性を解明する一助となる成果が見られた。
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Report
(3 results)
Research Products
(106 results)
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[Journal Article] Frequent deletion of ING2 locus at 4q35. 1 associates with advanced tumor stage in head and neck squamous cell carcinoma2009
Author(s)
Borkosky, SS, Gunduz, M, Nagatsuka, H, Beder, LB, Gunduz, E, AI, Sheikh, Ali, M, Rodriguez, AP, Cilek, MZ, Tominaga, S, Yamanaka, N, Shimizu, K, Nagai, N
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Journal Title
J Cancer Res Clin Oncol 135巻5号
Pages: 703-713
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[Journal Article] Deletion at Dickkopf (dkk)-3 locus (11p15. 2) is related with lower lymph node metastasis and better prognosis in head and neck squamous cell carcinomas2008
Author(s)
Katase N, Gunduz M, Beder L, Gunduz E, Lefeuvre M, Hatipoglu OF, Borkosky SS, Tamamura R, Tominaga S, Yamanaka N, Shimizu K, Nagai N, Nagatsuka H
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Journal Title
Oncol Res 17巻6号
Pages: 273-282
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Peer Reviewed
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[Journal Article] Sequential expressions of Notchl, Jagged2 and Mathl in molar tooth germ of mouse2008
Author(s)
Borkosky SS, Nagatsuka H, Orita Y, Tsujigiwa H, Yoshinobu J, Gunduz M, Rodriguez AP, Missana LR, Nishizaki K, Nagai N,
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Journal Title
Biocell 32巻3号
Pages: 251-258
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Peer Reviewed
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[Journal Article] Lack of B-RAF mutations in head and neck squamous cell carcinoma2008
Author(s)
Al Sheikh Ali M, Gunduz M, Gunduz E, Tamamura R, Beder L, Tominaga S, Onoda T, Yamanaka N, Grenman R, Shimizu K, Nagai N, Nagatsuka H
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Journal Title
Folia Biol (Praha) 54巻5号
Pages: 157-161
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Peer Reviewed
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[Journal Article] Expression and mutation analysis of epidermal growth factor receptor in head and neck squamous cell carcinoma2008
Author(s)
Sheikh Ali MA, Gunduz M, Nagatsuka H, Gunduz E, Cengiz B, Fukushima K, Beder LB, Demircan K, Fujii M, Yamanaka N, Shimizu K, Grenman R, Nagai N
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Journal Title
Cancer Sci 99巻8号
Pages: 1589-1594
NAID
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Peer Reviewed
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[Journal Article] Downregulation of ING3 mRNA expression predicts poor prognosis in head and neck cancer2008
Author(s)
Gunduz M, Beder LB, Gunduz E, NagatsukaH, Fukushima K, Pehlivan D, Cetin E, Yamanaka N, Nishizaki K, Shimizu K, Nagai N
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Journal Title
Cancer Sci 99巻3号
Pages: 531-538
NAID
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Peer Reviewed
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[Journal Article] Deletion mapping of chromosome 4q22-35 and identification of four frequently deleted regions in head and neck cancers2008
Author(s)
Cetin E, Cengiz B, Gunduz E, Gunduz M, Nagatsuka H, Bekir-Beder L, Fukushima K, Pehlivan D, N MO, Nishizaki K, Shimizu K, Nagai N
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Journal Title
Neoplasma 55巻4号
Pages: 299-304
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Peer Reviewed
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[Journal Article] Involvement of EphA2 in head and neck squamous cell carcinoma : mRNA expression, loss of heterozygosity and immunohistochemical studies2008
Author(s)
Rivera RS, Gunduz M, Nagatsuka H, Gunduz E, Cengiz B, Fukushima K, Beder LB, Pehlivan D, Yamanaka N, Shimizu K, Nagai N
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Journal Title
Oncol Rep 19巻5号
Pages: 1079-1084
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[Journal Article] Fine deletion mapping of chromosome 2q21-37 shows three preferentially deleted regions in oral cancer2007
Author(s)
Cengiz B, Gunduz M, Nagatsuka H, Beder L, Gunduz E, Tamamura R, Mahmut N, Fukushima K, Ali MA, Naomoto Y, Shimizu K, Nagai N
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Journal Title
Oral Oncol 43巻3号
Pages: 241-247
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Peer Reviewed
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[Presentation] 上顎歯肉腫瘍2008
Author(s)
片瀬直樹
Organizer
第19回日本臨床口腔病理学会
Place of Presentation
東京
Year and Date
2008-08-21
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[Presentation] 下顎歯肉腫瘍2007
Author(s)
片瀬直樹
Organizer
第18回日本口腔病理学会総会・学術大会
Place of Presentation
岐阜
Year and Date
2007-08-10
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