The stduy of sensory and motor neurons in dystonin deficient dystonia musculorum mice.

• Project/Area Number: 19592110
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Okayama University
• Principal Investigator: ICHIKAWA Hiroyuki Okayama University, 大学院・歯学研究科, 教授 (20193435)
• Co-Investigator(Kenkyū-buntansha): 杉本 朋貞 岡山大学, 大学院・医歯薬学総合研究科, 教授 (50135729)
• Project Period (FY): 2007 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: ジストニン / ノックアウトマウス / 知覚ニューロン / 運動ニューロン / 三叉神経中脳路核 / 三叉神経節 / isolectin B4 / TrkA / CGRP / caspase 3 / ノックアウト / 中脳路核 / カスパーゼ / パルブアルブミン / 免疫組織化学 / マウス

Research Abstract

The trigeminal motor nucleus, mesencephalic trigeminal tract nucleus and trigeminal ganglion were investigated in wild type and dystonia musculorum (dt) mice to study the effect of dystonin deficiency on motor and sensory neurons in the trigeminal nervous system.

Research Products

• [Journal Article] Increase of CGRP Expression in Motor Endplates Within Fore and Hind Limb Muscles of the Degenerating Muscle Mouse (Scn8a ( dmu )). (2011)
  • Author(s): Sato T, Shimizu Y, Kano M, Suzuki T, Kanetaka H, Chu LW, Cote PD, Shimauchi H, Ichikawa H
  • Journal Title: Cell Mol Neurobiol. 巻未定印刷中
  • Peer Reviewed
• [Journal Article] Increase of CGRP Expression in Motor Endplates Within Fore and Hind Limb Muscles of the Degenerating Muscle Mouse (Scn8a(dmu )). (2011)
  • Author(s): T.Sato, et al.
  • Journal Title: Cell Mol Neurobiol Volume: 未定
  • Peer Reviewed
• [Journal Article] Increase of c-Fos and c-Jun Expression in Spinal and Cranial Motoneurons of the Degenerating Muscle Mouse (Scn8a ( dmu )). (2010)
  • Author(s): Ichikawa H, Kano M, Shimizu Y, Suzuki T, Sawada E, Ono W, Chu LW, Cote PD
  • Journal Title: Cell Mol Neurobiol. 30 Pages: 737-742
  • Peer Reviewed
• [Journal Article] Increase of c-Fos and c-Jun Expression in Spinal and Cranial Motoneurons of the Degenerating Muscle Mouse (Scn8a (dmu)) (2010)
  • Author(s): Ichikawa H, Kano M, Shimizu Y, Suzuki T, Sawada E, Ono W, Chu LW, Cote PD.
  • Journal Title: Cell Mol Neurobiol (印刷中)
  • Peer Reviewed
• [Journal Article] Increase of c-Fos and c-Jun Expression in Spinal and Cranial Motoneurons of the Degenerating Muscle Mouse(Scn8a(dmu)). (2010)
  • Author(s): H.Ichikawa, et al.
  • Journal Title: Cell Mol Neurobiol (未定, accepted)
  • Peer Reviewed
• [Journal Article] The number of nociceptors in the trigeminal ganglion but not proprioceptors in the mesencephalic trigeminal tract nucleus is reduced in dystonin deficient dystonia musculorum mice. (2008)
  • Author(s): Ichikawa H, Terayama R, Yamaai T, De Repentigny Y, Kothary R, Sugimoto T
  • Journal Title: Brain Res. 1226 Pages: 33-38
  • Peer Reviewed
• [Journal Article] The number of nociceptors in the trigeminal ganglion but not proprioceptors in the mesencephalic trigeminal tract nucleus is reduced in dystonin deficient dystonia musculorum mice (2008)
  • Author(s): Ichikawa H, Terayama R, Yamaai T, De Repentigny Y, Kothary R, Sugimoto T
  • Journal Title: Brain Res. 1226 Pages: 33-38
  • Peer Reviewed
• [Journal Article] The number of nociceptors in the trigeminal ganglion but not proprioceptors in the mesencephalic trigeminal tract nucleus is reduced in dystonin deficient dystonia musculorum mice (2008)
  • Author(s): Ichikawa, et al.
  • Journal Title: Brain Research 1226 Pages: 33-38
  • Peer Reviewed
• [Journal Article] Dystonin deficiency reduces taste buds and fungiform papillae in the anterior part of the tongue. (2007)
  • Author(s): Ichikawa H, Terayama R, Yamaai T, De Repentigny Y, Kothary R, Sugimoto T
  • Journal Title: Brain Res. 1129 Pages: 142-146
  • Peer Reviewed
• [Journal Article] Dystonin deficiency reduces taste buds and fungiform papillae in the anterior part of the tongue (2007)
  • Author(s): Ichikawa H, Terayama R, Yamaai T, De Repentigny Y, Kothary R, Sugimoto T.
  • Journal Title: Brain Res. 1129 Pages: 142-146
  • Peer Reviewed
• [Journal Article] Brain-derived neurotrophic factor-immunoreactive neurons in the rat vagal and glossopharyngeal sensory ganglia (2007)
  • Author(s): H. Ichiltawa, et. al.
  • Journal Title: Brain Research 1155 Pages: 93-99
  • Peer Reviewed
• [Journal Article] The reduction of proprioceptors in the mesencephalic trigeminal tract nucleus after neonatal masseteric nerve transection (2007)
  • Author(s): H. Ichikawa, et. al.
  • Journal Title: Brain Research 1153 Pages: 98-102
  • Peer Reviewed
• [Remarks] ホームページ等