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The stduy of sensory and motor neurons in dystonin deficient dystonia musculorum mice.

Research Project

Project/Area Number 19592110
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionOkayama University

Principal Investigator

ICHIKAWA Hiroyuki  Okayama University, 大学院・歯学研究科, 教授 (20193435)

Co-Investigator(Kenkyū-buntansha) 杉本 朋貞  岡山大学, 大学院・医歯薬学総合研究科, 教授 (50135729)
Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsジストニン / ノックアウトマウス / 知覚ニューロン / 運動ニューロン / 三叉神経中脳路核 / 三叉神経節 / isolectin B4 / TrkA / CGRP / caspase 3 / ノックアウト / 中脳路核 / カスパーゼ / パルブアルブミン / 免疫組織化学 / マウス
Research Abstract

The trigeminal motor nucleus, mesencephalic trigeminal tract nucleus and trigeminal ganglion were investigated in wild type and dystonia musculorum (dt) mice to study the effect of dystonin deficiency on motor and sensory neurons in the trigeminal nervous system.

Report

(6 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (13 results)

All 2011 2010 2008 2007 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Remarks (1 results)

  • [Journal Article] Increase of CGRP Expression in Motor Endplates Within Fore and Hind Limb Muscles of the Degenerating Muscle Mouse (Scn8a ( dmu )).2011

    • Author(s)
      Sato T, Shimizu Y, Kano M, Suzuki T, Kanetaka H, Chu LW, Cote PD, Shimauchi H, Ichikawa H
    • Journal Title

      Cell Mol Neurobiol. 巻未定印刷中

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increase of CGRP Expression in Motor Endplates Within Fore and Hind Limb Muscles of the Degenerating Muscle Mouse (Scn8a(dmu )).2011

    • Author(s)
      T.Sato, et al.
    • Journal Title

      Cell Mol Neurobiol

      Volume: 未定

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increase of c-Fos and c-Jun Expression in Spinal and Cranial Motoneurons of the Degenerating Muscle Mouse (Scn8a ( dmu )).2010

    • Author(s)
      Ichikawa H, Kano M, Shimizu Y, Suzuki T, Sawada E, Ono W, Chu LW, Cote PD
    • Journal Title

      Cell Mol Neurobiol. 30

      Pages: 737-742

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increase of c-Fos and c-Jun Expression in Spinal and Cranial Motoneurons of the Degenerating Muscle Mouse (Scn8a (dmu))2010

    • Author(s)
      Ichikawa H, Kano M, Shimizu Y, Suzuki T, Sawada E, Ono W, Chu LW, Cote PD.
    • Journal Title

      Cell Mol Neurobiol (印刷中)

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Increase of c-Fos and c-Jun Expression in Spinal and Cranial Motoneurons of the Degenerating Muscle Mouse(Scn8a(dmu)).2010

    • Author(s)
      H.Ichikawa, et al.
    • Journal Title

      Cell Mol Neurobiol (未定, accepted)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The number of nociceptors in the trigeminal ganglion but not proprioceptors in the mesencephalic trigeminal tract nucleus is reduced in dystonin deficient dystonia musculorum mice.2008

    • Author(s)
      Ichikawa H, Terayama R, Yamaai T, De Repentigny Y, Kothary R, Sugimoto T
    • Journal Title

      Brain Res. 1226

      Pages: 33-38

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The number of nociceptors in the trigeminal ganglion but not proprioceptors in the mesencephalic trigeminal tract nucleus is reduced in dystonin deficient dystonia musculorum mice2008

    • Author(s)
      Ichikawa H, Terayama R, Yamaai T, De Repentigny Y, Kothary R, Sugimoto T
    • Journal Title

      Brain Res. 1226

      Pages: 33-38

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] The number of nociceptors in the trigeminal ganglion but not proprioceptors in the mesencephalic trigeminal tract nucleus is reduced in dystonin deficient dystonia musculorum mice2008

    • Author(s)
      Ichikawa, et al.
    • Journal Title

      Brain Research 1226

      Pages: 33-38

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dystonin deficiency reduces taste buds and fungiform papillae in the anterior part of the tongue.2007

    • Author(s)
      Ichikawa H, Terayama R, Yamaai T, De Repentigny Y, Kothary R, Sugimoto T
    • Journal Title

      Brain Res. 1129

      Pages: 142-146

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dystonin deficiency reduces taste buds and fungiform papillae in the anterior part of the tongue2007

    • Author(s)
      Ichikawa H, Terayama R, Yamaai T, De Repentigny Y, Kothary R, Sugimoto T.
    • Journal Title

      Brain Res. 1129

      Pages: 142-146

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Brain-derived neurotrophic factor-immunoreactive neurons in the rat vagal and glossopharyngeal sensory ganglia2007

    • Author(s)
      H. Ichiltawa, et. al.
    • Journal Title

      Brain Research 1155

      Pages: 93-99

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The reduction of proprioceptors in the mesencephalic trigeminal tract nucleus after neonatal masseteric nerve transection2007

    • Author(s)
      H. Ichikawa, et. al.
    • Journal Title

      Brain Research 1153

      Pages: 98-102

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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