Regulation of osteogenesis and skeketal patterning by Hox9

• Project/Area Number: 19592119
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Nagasaki University
• Principal Investigator: SHIBATA Yasuaki Nagasaki University, 大学院・医歯薬学総合研究科, 助教 (80253673)
• Co-Investigator(Kenkyū-buntansha): FUJITA Shuichi 長崎大学, 大学院・医歯薬学総合研究科, 準教授 (00181355) ; IKEDA Tohru 長崎大学, 大学院・医歯薬学総合研究科, 教授 (00211029)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 口腔解剖学(含組織学・発生学) / 骨芽細胞 / hoxc9 / BMP / runx2 / smads

Research Abstract

Hoxc9の発現はrhBMP-2によって正に、smad-2によって負に制御されており、かつHoxc9はアルカリフォスファターゼ(ALP)の発現を正に制御した。すなわちHoxc9は骨分化に促進的に関与することが明らかになった。

Research Products

• [Journal Article] Photo-induced hydrophilicity enhances initial cell behavior and early bone apposition (2008)
  • Author(s): Sawase, T., Jimbo, R., Baba, K., Shibata, Y., Ikeda, T., Atsuta, M
  • Journal Title: Clin. Oral Impl. Res 19 Pages: 491-496
  • Peer Reviewed
• [Journal Article] The slow resorption with replacement by bone of a hydrothermally synthesized pure calcium-deficient hydroxyapatite (2008)
  • Author(s): Okuda, T., Ioku, K., Yonezawa, I., Minagi, H., Gonda, Y., Kawachi, G., Kamitakahara, M., Shibata, Y., Murayama, H., Kurosawa, H., Ikeda, T
  • Journal Title: Biomaterials 29 Pages: 2719-2728
  • Peer Reviewed
• [Journal Article] Enhanced initial cell responses to chemically modified anodized titanium (2008)
  • Author(s): Jimbo, R., Sawase, T., Baba, K., Kurogi, T., Shibata, Y., Atsuta, M
  • Journal Title: Clin Implant Dent Relat Res 10 Pages: 55-61
  • NAID: 120006984724
  • Peer Reviewed
• [Journal Article] Photo-induced hydrophilicity enhances initial cell behavior and early bone apposition. (2008)
  • Author(s): Sawase T, et al.
  • Journal Title: Clin. Oral Impl. Res. 19 Pages: 491-496
  • Peer Reviewed
• [Journal Article] The slow resorption with replacement by bone of a hydr o-thermally synthesized pure calcium -deficient hydroxyapatite. (2008)
  • Author(s): Okuda T, et al.
  • Journal Title: Biomaterials 29 Pages: 2719-2728
  • Peer Reviewed
• [Journal Article] Enhanced initial cell responses to chemically modified anodized titani um. (2008)
  • Author(s): Jimbo R, et al.
  • Journal Title: Clin Implant Dent Relat Res. 10 Pages: 55-61
  • Peer Reviewed
• [Journal Article] Enhanced initial cell responses to chemically modified anodized titanium (2008)
  • Author(s): Jimbo R, et. al.
  • Journal Title: Clin Implant Dent Relat Res 10 Pages: 55-61
  • Peer Reviewed
• [Journal Article] The effect of the microstructure of b-tricalcium phosphate on the metabolism of subsequently formed bone tissue (2007)
  • Author(s): Okuda T, Ioku K, Yonezawa I, Minagi H, Kawachi G, Gonda Y, Murayama H, Shibata Y, Minami S, Kamihira S, Kurosawa H, Ikeda T
  • Journal Title: Biomaterials 28 Pages: 2612-22621
  • Peer Reviewed
• [Journal Article] Enhanced osseointegration by the chemotactic activity of plasma fibronectin for cellular fibronectin positive cells (2007)
  • Author(s): Jimbo R, Sawase T, Shibata Y, Hirata K, Hishikawa Y, Tanaka Y, Bessho K, Ikeda T, Atsuta M
  • Journal Title: Biomaterials 28 Pages: 3469-3477
  • NAID: 120006984664
  • Peer Reviewed
• [Journal Article] BMP-2 promotes differentiation of osteoblasts and chondroblasts in Runx2-deficient cell lines (2007)
  • Author(s): Liu T, Gao Y, Sakamoto K, Minamizato T, Furukawa K, Tsukazaki T, Shibata Y, Bessho K, Komori T, Yamaguchi A
  • Journal Title: J Cell Physiol 211 Pages: 728-735
  • Peer Reviewed
• [Journal Article] The effect of the microstructure of beta-tricalcium phosphate on the metabolism of subsequently formed bone tissue (2007)
  • Author(s): Okuda T, et. al.
  • Journal Title: Biomaterials 28 Pages: 2612-2621
  • Peer Reviewed
• [Journal Article] Enhanced osseointegration by the chemotactic activity of plasma fibronectin for cellular fibronectin positive cells (2007)
  • Author(s): Jimbo R, et. al.
  • Journal Title: Biomaterials 28 Pages: 3469-3477
  • Peer Reviewed
• [Presentation] 柱状粒子ハイドロキシアパタイト球状顆粒の骨組織への移植による吸収と骨伝導(抄録集演題番号P-191, p.183) (2008)
  • Author(s): 権田芳範、柴田恭明、井奥洪二、池田通
  • Organizer: 第50 回歯科基礎医学会総会
  • Place of Presentation: 東京
• [Presentation] 柱状粒子β-リン酸三カルシウム球状顆粒の不動化骨組織における吸収と骨伝導(抄録集演題番号P2-26, p.240) (2008)
  • Author(s): 権田芳範、奥田貴俊、井奥洪二、柴田恭明、米澤郁穂、黒澤尚、池田通
  • Organizer: 第26 回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 胸腺上皮細胞株及び胎仔胸腺器管培養を用いたAIRE発現制御機構の検討 (2008)
  • Author(s): 吉松昌子, 柴田恭明, 関 幸子, 笠井道之, 池田通
  • Organizer: 第19回Kyoto T Cell Conference
  • Place of Presentation: 京都
• [Presentation] デキサメタゾンによる胸腺AIRE 発現制御 (2008)
  • Author(s): 柴田恭明, 吉松昌子, 関 幸子, 笠井道之, 池田通
  • Organizer: 第49回日本組織細胞化学会総会・学術集会
  • Place of Presentation: 長崎
• [Presentation] 柱状粒子ハイドロキシアパタイト球状顆粒の骨組織への移植による吸収と骨伝導 (2008)
  • Author(s): 権田芳典
  • Organizer: 第50回歯科基礎医学会総会
  • Place of Presentation: 東京
• [Presentation] 柱状粒子β-リン酸三カルシウム球状顆粒の不動化骨組織における吸収と骨伝導 (2008)
  • Author(s): 権田芳範
  • Organizer: 第26回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
• [Presentation] デキサメタソンによる胸腺AIRE発現制御 (2008)
  • Author(s): 柴田恭明
  • Organizer: 第49回日本組織細胞化学会総会
  • Place of Presentation: 長崎
• [Presentation] 骨代替材料の吸収性と新生骨形成の関係に対する評価(抄録集演題番号P1-63, p.254) (2007)
  • Author(s): 奥田貴俊, 井奥洪二, 米澤郁穂, 権田芳範, 柴田恭明, 黒澤 尚, 池田通
  • Organizer: 第25回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 微細柱状粒子β-リン酸三カルシウム球状顆粒の開発と骨代替材料としての評価(抄録集演題番号P1-67, p.256) (2007)
  • Author(s): 権田芳範, 奥田貴俊, 井奥洪二, 米澤郁穂, 黒澤 尚, 柴田恭明, 池田通
  • Organizer: 第25 回日本骨代謝学会学術集会
  • Place of Presentation: 大阪