| Project/Area Number |
19592124
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
GOTO Tetsuya Kyushu Dental College, 歯学部, 准教授 (70253458)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Shigeru 九州歯科大学, 歯学部, 教授 (10118078)
牧 憲司 九州歯科大学, 歯学部, 教授 (60209400)
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| Co-Investigator(Renkei-kenkyūsha) |
MAKI Kenshi 九州歯科大学, 歯学部, 教授 (60209400)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 神経ペプチド / 知覚神経 / 三叉神経節 / 骨芽細胞 / 破骨細胞 / 顎骨 / ニューロキニンB |
|---|
| Research Abstract |
For studying the cooperative regulation of bone metabolism between upper and lower jaw through the trigeminal ganglion, we examined the regulation system by using the cultured osteoblasts and the orthodontic tooth movement model for the rat upper molar. Our results demonstrated that the neurons for mandibular and maxilla secret the neuropeptides, such as substance P and neurokinin B, to regulate their bone metabolism through the activation of satellite cells around the neurons.
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