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Role of Six gene in the morphogenesis of lingual papillae and taste buds

Research Project

Project/Area Number 19592125
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

SUZUKI Yuko)  Health Sciences University of Hokkaido, 歯学部, 准教授 (90137422)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsSix遺伝子 / 茸状乳頭 / 有郭乳頭 / 葉状乳頭 / 味蕾 / 転写因子 / Six1 / Six4 / Six1欠損マウス / in situ hybridization / 免疫組織化学
Research Abstract

Sixホメオボックス遺伝子は眼、耳、鼻などの感覚器の発生に共通して作用することが知られ、なかでもSix1 とSix4が欠損すると嗅上皮や内耳の形成が著しく阻害される。味覚器である味蕾と味蕾を生じる舌乳頭に影響があるかどうか組織学的手法を用いて調べた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (20 results)

All 2009 2008 2007

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (10 results) Book (2 results)

  • [Journal Article] Expression of Sox2 in relation to innervation2008

    • Author(s)
      Suzuki Y
    • Journal Title

      Cell Tissue Res 332

      Pages: 393-401

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Sox2 in mouse taste buds and its relation to innervation2008

    • Author(s)
      Suzuki Y.
    • Journal Title

      Cell Tissue Research 332

      Pages: 393-401

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 有郭乳頭と味蕾の分化におけるSox2の発現2008

    • Author(s)
      鈴木裕子
    • Journal Title

      日本味と匂学会誌 15

      Pages: 347-348

    • NAID

      110007369636

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Uchida N. Detection of neurotrophic factors in taste buds by laser capture microdissection2007

    • Author(s)
      Suzuki Y, Mizoguchi I
    • Journal Title

      immunohistochemistry, and in situ hybridization. Arch. Histol. Cytol 70

      Pages: 117-126

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Apoptosis and the insulin-like growth factor family in the developing olfactory epithelium2007

    • Author(s)
      Suzuki Y
    • Journal Title

      Anat. Sci. Int 82

      Pages: 200-206

    • NAID

      10019992587

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of neurotrophic factors in taste buds by laser capture microdissection,immunohistochemistry,and in situ hybridization2007

    • Author(s)
      Suzuki Y, Mizoguchi I, Uchida N
    • Journal Title

      Arch.Histol.Cytol 70

      Pages: 117-126

    • NAID

      10019551037

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apoptosis and the insulin-like growth factor family in the developing olfactory epithelium2007

    • Author(s)
      Suzuki Y
    • Journal Title

      Anatomical Science International 82

      Pages: 200-206

    • NAID

      10019992587

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 舌乳頭形成に関わるSix1遺伝子2007

    • Author(s)
      鈴木 裕子、池田 啓子、川上 潔
    • Journal Title

      日本味と匂学会誌 14

      Pages: 267-268

    • NAID

      110006651209

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 嗅上皮と味蕾における転写因子Sixの局在2009

    • Author(s)
      鈴木裕子
    • Organizer
      解剖学会総会
    • Place of Presentation
      岡山
    • Year and Date
      2009-03-30
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 転写因子Sox2の味蕾における発現と神経支配の関係2008

    • Author(s)
      鈴木裕子
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      東京
    • Year and Date
      2008-09-25
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] マウス下顎頭軟骨発生過程におけるIGF familyの発現に関する研究2008

    • Author(s)
      柴田俊一、田巻玉器、鈴木裕子
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      東京
    • Year and Date
      2008-09-25
    • Related Report
      2008 Final Research Report
  • [Presentation] 舌乳頭形成過程におけるSix4の発現2008

    • Author(s)
      鈴木裕子、池田啓子、川上潔
    • Organizer
      解剖学会総会
    • Place of Presentation
      大分
    • Year and Date
      2008-03-29
    • Related Report
      2008 Final Research Report
  • [Presentation] 舌乳頭形成過程におけるSix4の発現2008

    • Author(s)
      鈴木 裕子、池田 啓子、川上 潔
    • Organizer
      第113回解剖学会総会、全国学術集会
    • Place of Presentation
      大分
    • Year and Date
      2008-03-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] 有郭乳頭と味蕾の分化におけるSox2の発現2008

    • Author(s)
      鈴木裕子
    • Organizer
      日本味と匂学会
    • Place of Presentation
      富山
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 再生および発達過程の味蕾のSix12007

    • Author(s)
      鈴木裕子、恒川寛明、内田暢彦
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      札幌
    • Year and Date
      2007-08-31
    • Related Report
      2008 Final Research Report
  • [Presentation] 再生および発達過程の味蕾のSix12007

    • Author(s)
      鈴木 裕子、恒川 寛明、内田 暢彦
    • Organizer
      第49回歯科基礎医学会
    • Place of Presentation
      札幌
    • Year and Date
      2007-08-31
    • Related Report
      2007 Annual Research Report
  • [Presentation] 舌乳頭形成に関わるSix1遺伝子2007

    • Author(s)
      鈴木裕子、池田啓子、川上潔
    • Organizer
      日本味と匂学会
    • Place of Presentation
      東京
    • Year and Date
      2007-07-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 舌乳頭形成に関わるSix遺伝子2007

    • Author(s)
      鈴木 裕子、池田 啓子、川上 潔
    • Organizer
      第41回日本味と匂学会
    • Place of Presentation
      東京
    • Year and Date
      2007-07-28
    • Related Report
      2007 Annual Research Report
  • [Book] 「匂いと香りの科学」嗅覚器の発生(渋谷達明、市川真澄編)2007

    • Author(s)
      鈴木裕子
    • Publisher
      朝倉書店
    • Related Report
      2008 Final Research Report
  • [Book] レーヴンジョンソン生物学、活動のための燃料の供給:消化2007

    • Author(s)
      鈴木裕子
    • Publisher
      培風館
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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