Cell dynamics in transition stage from crown to tooth root formation and effects of growth factors in development of Hertwig epithelial root sheath
| Project/Area Number |
19592128
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Iwate Medical University |
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Principal Investigator |
FUJIWARA Naoki Iwate Medical University, 歯学部, 講師 (20190100)
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| Co-Investigator(Kenkyū-buntansha) |
鍵谷 忠慶 岩手医科大学, 歯学部, 助教 (30405774)
石関 清人 岩手医科大学, 歯学部, 准教授 (50057775)
大島 勇人 新潟大学, 医歯学系, 教授 (70251824)
原田 英光 岩手医科大学, 歯学部, 教授 (70271210)
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| Co-Investigator(Renkei-kenkyūsha) |
HARADA Hidemitsu 岩手医科大学, 歯学部, 教授 (70271210)
OHSHIMA Hayato 新潟大学, 医歯学系, 教授 (70251824)
ISHIZEKI Kiyoto 岩手医科大学, 歯学部, 准教授 (50057775)
KAGIYA Tadayoshi 岩手医科大学, 歯学部, 助教 (30405774)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 歯の発生 / 歯根形成 / ヘルトヴィッヒ上皮鞘 / 器官培養 / EGF / サービカルループ / 上皮成長因子 / GFP / 歯根形戌 |
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| Research Abstract |
臼歯の歯根形成にはヘルトヴィッヒ上皮鞘(HERS)が重要な役割を果たすことが知られているが、その中で理解が乏しいHERS発達のメカニズムについて今回検討した。我々は2つのオリジナルな器官培養系を用いて上皮成長因子epidermal growth factor、インスリン様成長因子insulin-like growth factor-Iが、それぞれ歯冠形成からHERS形成の移行時期、HERSの伸長・発達に重要な作用を示すことを明らかにした。
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Report
(3 results)
Research Products
(47 results)
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[Journal Article] MAPK mediates Hsp25 signaling in incisor development2009
Author(s)
Lee, MJ, Cai, J, Kwak, SW, Cho, SW, Harada, H, Jung, HS.
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Journal Title
Histochem Cell Biol 19(e-Pub)
Related Report
Peer Reviewed
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[Journal Article] Egf signaling regulates transition from crown to root formation in the development of mouse molars2008
Author(s)
Fujiwara, N., Akimoto, T., Kagiya, T., Ishizeki, K., Harada, H.
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Journal Title
Journal of Experimental Zoology-Molecular and Developmental Evolution, Dec. 17(e-Pub)
Related Report
Peer Reviewed
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[Journal Article] BMP2-induced gene profiling in dental epithelial cell line2008
Author(s)
Miyoshi, K., Nagata, H., Horiguchi, T., Abe, K., Wahyudi, I.A., Baba, Y., Harada H., Noma, T.
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Journal Title
J. Med. Invest 55
Pages: 216-226
NAID
Related Report
Peer Reviewed
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[Journal Article] Establishment of immortalized dental follicle cells for generating periodontal ligament in vivo2007
Author(s)
Yokoi, T., Saito, M., Kiyono, T., Iseki, S., kosaka,K., Nishida, E., Tsubakimoto, T., Harada, H., Eto, K., Noguchi, T. and Teranaka, T.
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Journal Title
Cell Tissue Res. 327(2)
Pages: 301-11
Related Report
Peer Reviewed
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[Presentation] Hertwig's epithelial root sheath is made of outer enamel epithelium2008
Author(s)
Fujiwara, N., Kagiya, T., Ishizeki, K., Otsu, K., Akimoto and T., Harada, H.
Organizer
Gordon Research Conference on Craniofacial Morphogenesis & Tissue Regeneration
Place of Presentation
Ciocco, Barga, Italy
Related Report
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[Presentation] Mechanisms on maintenance of dental stem cells and how to make a biotooth2007
Author(s)
Harada, H., Fujiwara, N., Yokohama-Tamaki, T., Kagiya, T., Tabata, Y. and Ishizeki. K.
Organizer
1^<st> Asian Biomaterials Congress(Integrated Congress of 6^<th> Asian International Symposium on Biomaterials and 8^<th> Asian Symposium on Biomedical Materials)
Place of Presentation
Tsukuba, Japan
Year and Date
2007-12-08
Related Report
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