| Project/Area Number |
19592131
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
|
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
ABE Shin-ichi Tokyo Dental College, 歯学部, 准教授 (40256300)
|
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| Co-Investigator(Kenkyū-buntansha) |
崎山 浩司 東京歯科大学, 歯学部, 助教 (50385142)
吉成 正雄 東京歯科大学, 歯学部, 准教授 (10085839)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 筋線維 / 筋活性 / 成長因子 / 筋幹細胞 / 筋原線維 / 筋機能 / 筋芽細胞 / 筋収縮タンパク / 筋衛星細胞 / 筋SP細胞 / IGF-1 / 遺伝子導入 / 細胞内ストレス / 筋肥大 / 細胞伸展 |
|---|
| Research Abstract |
Decreased muscle function is a major cause of the deterioration of eating function including mastication and swallowing in the elderly. We evaluated two processes involved in the mechanism of restoring muscle function. In one process, muscle protein synthesis (promotion) exceeded its degradation (inhibition), and a resulting increase in muscle fiber thickness increases muscle tissue weight, and also improves muscle function. In the other process, muscle-specific stem cells produce new muscle fibers. Thus, the interaction of various factors is important.
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