| Project/Area Number |
19592134
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
SHIMONO Masaki Tokyo Dental College, 歯学部, 教授 (00085771)
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| Co-Investigator(Kenkyū-buntansha) |
橋本 貞充 東京歯科大学, 歯学部, 准教授 (10201708)
村松 敬 東京歯科大学, 歯学部, 講師 (00276982)
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| Research Collaborator |
正岡 孝康 東京歯科大学, 歯学部
杉澤 幹雄 東京歯科大学, 歯学部
土谷 穏史 東京歯科大学, 歯学部
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 付着上皮 / 実験的歯周炎 / 細胞接着 / 細胞移動 / 内側基底板 / laminin γ_2 / integrin β_4 / integrin α_3 / 長い付着上皮 / 接着タンパク / laminin5 / Integrinα_6β_4 / Iaminin 5 |
|---|
| Research Abstract |
The aim of this study was, examine the expression of laminin γ_2, integrin β_4 and integrin α_3 in the normal and regenerating gingival junctional epithelium in order to understand the mechanism of wound healing and function of cell migration. Our results suggest that secretion of laminin γ_2 in the connective tissue may induce epithelial cell migration, and that binding of laminin γ_2 to integrin α_6β_4 and integrin α_3β_1 in the IBL may provoke cell adhesion and migration of cells facing the tooth on the enamel surface of the regenerating junctional epithelium.
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