Molecular mechanism of cell adhesion and cell migration in gingival junctional epithelium.
| Project/Area Number |
19592134
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
SHIMONO Masaki Tokyo Dental College, 歯学部, 教授 (00085771)
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| Co-Investigator(Kenkyū-buntansha) |
橋本 貞充 東京歯科大学, 歯学部, 准教授 (10201708)
村松 敬 東京歯科大学, 歯学部, 講師 (00276982)
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| Research Collaborator |
正岡 孝康 東京歯科大学, 歯学部
杉澤 幹雄 東京歯科大学, 歯学部
土谷 穏史 東京歯科大学, 歯学部
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 付着上皮 / 実験的歯周炎 / 細胞接着 / 細胞移動 / 内側基底板 / laminin γ_2 / integrin β_4 / integrin α_3 / 長い付着上皮 / 接着タンパク / laminin5 / Integrinα_6β_4 / Iaminin 5 |
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| Research Abstract |
The aim of this study was, examine the expression of laminin γ_2, integrin β_4 and integrin α_3 in the normal and regenerating gingival junctional epithelium in order to understand the mechanism of wound healing and function of cell migration. Our results suggest that secretion of laminin γ_2 in the connective tissue may induce epithelial cell migration, and that binding of laminin γ_2 to integrin α_6β_4 and integrin α_3β_1 in the IBL may provoke cell adhesion and migration of cells facing the tooth on the enamel surface of the regenerating junctional epithelium.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Ca2+ Extrusion via Na+-Ca2+ Exchangers in Rat Odontoblasts.2010
Author(s)
Tsumura M., Okumura R., Tatsuyama S., Ichikawa H., Muramatsu T., Matsuda T., Baba A., Suzuki K., Kajiya H., Sahara Y., Tokuda M., Momose Y., Tazaki M., Shimono M., Shibukawa Y.
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Journal Title
Journal of Endodontics 36(4)
Pages: 668-674
Related Report
Peer Reviewed
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