Taste of fatty acids and taste modulation by fatty acids

• Project/Area Number: 19592149
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Functional basic dentistry
• Research Institution: Kyushu University
• Principal Investigator: YASUMATSU Keiko Kyushu University, 大学院・歯学研究院, 研究員 (50380704)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 生理学 / 神経科学 / 味覚 / 脂肪酸 / 受容 / 鼓索神経 / 舌咽神経 / 脂肪酸受容体 / 遺伝子改変マウス

Research Abstract

本研究課題において、脂肪酸の味覚および味覚修飾について味覚神経応答と組織学的検索を行った。脂肪酸による味覚神経応答と、苦味抑制が見られKO マウス実験により脂肪酸受容・伝達に関わる分子が示唆された。

Research Products

• [Journal Article] Multiple sweet receptors and transduction pathways revealed in knockout mice by temperature dependence and gurmarin sensitivity (2009)
  • Author(s): Ohkuri T, Yasumatsu K, Horio N, Jyotaki M, Margolskee RF, Ninomiya Y
  • Journal Title: Am J Physiol Regul Integr Comp Physiol 296 Pages: 960-971
  • Peer Reviewed
• [Journal Article] NaCl responsive taste cells in the mouse fungiform taste buds (2009)
  • Author(s): Yoshida R, Horio N, Murata Y, Yasumatsu K, Shigemura N, Ninomiya Y
  • Journal Title: Neuroscience 159 Pages: 795-803
  • Peer Reviewed
• [Journal Article] Multiple receptors underlie glutamate tasteresponses in mice. (2009)
  • Author(s): Yasumatsu K, Horio N, MurataY, Shirosaki S, Ohkuri T, Yoshida R, Ninomiya Y
  • Journal Title: Am. J. Clin, Nutr. (In press)
  • Peer Reviewed
• [Journal Article] Multiple sweet receptors and transduction pathways revealed in knockout mice by temperature dependence and gurmarin sensitivity. (2009)
  • Author(s): Ohkuri T, Yasumatsu K, Horio N, Jyotaki M, Margolskee RF, Ninomiya Y.
  • Journal Title: Am J Physiol Regul Integr Comp Physiol. 296
  • Peer Reviewed
• [Journal Article] NaCl responsive taste cells in the mouse fungiform taste buds. (2009)
  • Author(s): Yoshida R, Horio N, Murata Y, Yasumatsu K, Shigemura N, Ninomiya Y
  • Journal Title: Neuroscience. 159 Pages: 795-803
  • Peer Reviewed
• [Journal Article] Multiple receptor systems for glutamate detection in the taste organ (2008)
  • Author(s): Yasuo T, Kusuhara Y, Yasumatsu K, Ninomiya Y
  • Journal Title: Biol Pharm Bull 31 Pages: 1833-1837
  • NAID: 110006936316
  • Peer Reviewed
• [Journal Article] マウス鼓索神経挫滅後の再生過程におけるうま味応答の回復 (2008)
  • Author(s): 楠原庸子、安松啓子、大栗弾宏、堀尾奈央、前田勝正、二ノ宮裕三
  • Journal Title: 日本味と匂学会誌 15 Pages: 289-292
  • NAID: 110007369620
  • Peer Reviewed
• [Journal Article] Gurmarin sensitivity of sweet taste responses is associated with co-expression patterns of T1r2, T1r3, and gustducin (2008)
  • Author(s): Shigemura N, Nakao K, Yasuo T, Murata Y, Yasumatsu K, Nakashima A, Katsukawa H, Sako N, Ninomiya Y
  • Journal Title: Biochem. Biophys. Res. Commun. 367 Pages: 356-363
  • Peer Reviewed
• [Journal Article] Amiloride-sensitive NaCl taste responses are associated with genetic variation of ENaC alpha-subunit in mice (2008)
  • Author(s): Shigemura N, Ohkuri T, Sadamitsu C, Yasumatsu K, Yoshida R, Beauchamp GK, Bachmanov AA, Ninomiya Y
  • Journal Title: Am. J Physiol. Regul. Integr. Comp. Physiol 294 Pages: 66-75
  • Peer Reviewed
• [Journal Article] Multiple receptor systems for glutamate detection in the taste organ. (2008)
  • Author(s): Yasuo T, Kusuhara Y, Yasumatsu K Ninomiva Y
  • Journal Title: Biol Pharm Bull. 31 Pages: 1833-1837
  • NAID: 110006936316
  • Peer Reviewed
• [Journal Article] マウス鼓索神経挫滅後の再生過程におけるうま味応答の回復 (2008)
  • Author(s): 楠原庸子, 安松啓子, 大栗弾宏, 堀尾奈央, 前田勝正, 二ノ宮裕三
  • Journal Title: 日本味と匂学会誌 15 Pages: 289-292
  • NAID: 110007369620
  • Peer Reviewed
• [Journal Article] Gurmarin sensitivity of sweet taste responses is associated with co-expression patterns of T1r2,T1r3,and gustducin (2008)
  • Author(s): Shigemura N, Nakao K, Yasuo T, Murata Y, Yasumatsu K, Nakashima A, Katsukawa H, Sako N, Ninomiya Y.
  • Journal Title: Biochem.Biophys.Res.Commun. 367 Pages: 356-363
  • Peer Reviewed
• [Journal Article] Amiloride-sensitive NaCl taste responses are associated with genetic variation of ENaC alpha-subunit in mice (2008)
  • Author(s): Shigemura N, Ohkuri T, Sadamitsu C, Yasumatsu K, Yoshida R, Beauchamp GK, Bachmanov A A, Ninomiya Y.
  • Journal Title: Am J Physiol.Regul.Integr.Comp.Physiol. 294
  • Peer Reviewed
• [Journal Article] The taste transduction channel TRPM5 is a locus for bitter-sweet taste interactions (2007)
  • Author(s): Talavera K, Yasumatsu K, Yoshida R, Margolskee RF, Voets T, Ninomiya Y, Nilius B
  • Journal Title: FASEB J 22 Pages: 1343-1355
  • Peer Reviewed
• [Journal Article] Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor (2007)
  • Author(s): Hisatsune C, Yasumatsu K, Takahashi Iwanaga H, Ogawa N, Kuroda Y, Yoshida R, Ninomiya Y, Mikoshiba K
  • Journal Title: J Biol Chem 282 Pages: 37225-37231
  • Peer Reviewed
• [Journal Article] Recovery of two independent sweet taste systems during regeneration of the mouse chorda tympani nerve after nerve crush (2007)
  • Author(s): Yasumatsu K, Kusuhara Y, Shigemura N, Ninomiya Y
  • Journal Title: Eur J Neurosci 26 Pages: 1521-1529
  • Peer Reviewed
• [Journal Article] 塩味、酸味、苦味物質混合によるマウス鼓索神経甘味応答の修飾 (2007)
  • Author(s): 安松啓子、大栗弾宏、吉田竜介、DamakS、Margolskee RF、二ノ宮裕三
  • Journal Title: 日本味と匂学会誌 14 Pages: 387-390
  • NAID: 110006651244
  • Peer Reviewed
• [Journal Article] The taste transduction channel TRPM5 is a locus for bittersweet taste interactions (2007)
  • Author(s): Talavera K, Yasumatsu K, Yoshida R, Margolskee RF, Voets T, Ninomiya Y, Nilius B.
  • Journal Title: FASEB J. (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor (2007)
  • Author(s): Hisatsune C, Yasumatsu K, Takahashi-Iwanaga H, Ogawa N, Kuroda Y, Yoshida R, Ninomiya Y, Mikoshiba K.
  • Journal Title: J Biol Chem 282 Pages: 37225-37231
  • Peer Reviewed
• [Journal Article] Recovery of two independent sweet taste systems during regeneration of the mouse chorda tympani nerve after nerve crush (2007)
  • Author(s): Yasumatsu K, Kusuhara Y, Shigemura N, Ninomiya Y.
  • Journal Title: Eur J Neurosci. 26 Pages: 1521-1529
  • Peer Reviewed
• [Journal Article] 塩味、酸味、苦味物質混合によるマウス鼓索神経甘味応答の修飾 (2007)
  • Author(s): 安松 啓子、大栗 弾宏、吉田 竜介、Damak S、Margolskee RF、二ノ宮 裕三
  • Journal Title: 日本味と匂学会誌 14 Pages: 387-390
  • NAID: 110006651244
  • Peer Reviewed
• [Journal Article] Multiple receptors underlie glutamate taste responses in mice
  • Author(s): Yasumatsu K, Horio N, Murata Y, Shirosaki S, Ohkuri T, Yoshida R, Ninomiya Y
  • Journal Title: Am. J. Clin. Nutr (In press)
  • Peer Reviewed
• [Presentation] マウス鼓索神経再生時におけるうま味応答の回復 (2008)
  • Author(s): 安松啓子、楠原庸子、大栗弾宏、吉田竜介、二ノ宮裕三
  • Organizer: 第50回歯科基礎医学会
  • Place of Presentation: 東京
  • Year and Date: 2008-09-25
• [Presentation] マウス鼓索神経挫滅後の再生過程におけるうま味応答の回復 (2008)
  • Author(s): 楠原庸子、安松啓子、大栗弾宏、堀尾奈央、前田勝正、二ノ宮裕三
  • Organizer: 日本味と匂学会第42回大会
  • Place of Presentation: 富山
  • Year and Date: 2008-09-18
• [Presentation] Recovery of umami taste responses after crush of the mouse chorda tympani nerve (2008)
  • Author(s): Yasumatsu K, Kusuhara Y, Ninomiya Y
  • Organizer: ISOT XV
  • Place of Presentation: サンフランシスコ・USA
  • Year and Date: 2008-07-23
• [Presentation] Recovery of umami taste responses after crush of the mouse chorda tympam nerve (2008)
  • Author(s): Yasumatsu K, Kusuhara Y, Ninomiya Y.
  • Organizer: ISOT XV
  • Place of Presentation: サンフランシスコ・USA
  • Year and Date: 2008-07-23
• [Presentation] T1R3-KO, TRPM5-KO マウス単一鼓索神経記録によるうま味応答およびその細胞内伝達経路の解析 (2008)
  • Author(s): 安松啓子、吉田竜介、Margolskee RF、二ノ宮裕三
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10
• [Presentation] T1R3-KO, TRPM5-KOマウス単一鼓索神経記録によるうま味応答およびその細胞内伝達経路の解析 (2008)
  • Author(s): 安松啓子, 吉田竜介, Margolskee RF, 二ノ宮裕三
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10
• [Presentation] マウス鼓索神経ショ糖応答における苦味、塩味、酸味物質混合の効果 (2007)
  • Author(s): 安松啓子、大栗弾宏、吉田竜介、DamakS、Margolskee RF、二ノ宮裕三
  • Organizer: 第58回西日本生理学会
  • Place of Presentation: 福岡
  • Year and Date: 2007-10-20
• [Presentation] Modulations of sweet taste responses by salts, acids and bitter compounds in the mouse chorda tympani nerve (2007)
  • Author(s): Yasumatsu K, Yoshida R, Margolskee RF, Ninomiya Y
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-12
• [Presentation] Modulations of sweet taste responses by salts,acids and bitter compounds in the mouse chorda tvmnani nerve (2007)
  • Author(s): Yasumatsu K, Yoshida R, Margolskee RF, Ninomiya Y
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-12
• [Presentation] 塩味、酸味、苦味物質によるマウス鼓索神経甘味応答の修飾 (2007)
  • Author(s): 安松 啓子、大栗 弾宏、吉田 竜介、二ノ宮 裕三
  • Organizer: 第49回歯科基礎医学会
  • Place of Presentation: 札幌
  • Year and Date: 2007-08-30
• [Presentation] マウス鼓索神経における塩味、酸味、苦味物質混合ショ糖応答の解析 (2007)
  • Author(s): 安松啓子、大栗弾宏、吉田竜介、S. Damak、R.F. Margolskee、二ノ宮裕三
  • Organizer: 日本味と匂学会第41回大会
  • Place of Presentation: 東京
  • Year and Date: 2007-07-28
• [Presentation] Single fiber responses of the chorda tympani nerve to umami taste compounds in wild type, T1R3-KO and TRPM5-KO mice (2007)
  • Author(s): Yasumatsu K, Yoshida R, Murata Y, Damak S, Margolskee RF, Ninomiya Y
  • Organizer: AChemS XXIX
  • Place of Presentation: フロリダ・USA
  • Year and Date: 2007-04-28
• [Presentation] Single fiber responses of the chorda tympani nerve to umami taste compounds in wild type,T1R3-KO and TRPM5-KO mice (2007)
  • Author(s): Yasumatsu K, Yoshida R, Murata Y, Damak S, Margolskee RF, Ninomiya Y
  • Organizer: AChemS XXIX
  • Place of Presentation: フロリダ・USA
  • Year and Date: 2007-04-28