| Project/Area Number |
19592156
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
|
|---|
| Research Institution | Meikai University |
|---|
Principal Investigator |
SAKAGAMI Hiroshi Meikai University, 歯学部, 教授 (50138484)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Ken 明海大学, 歯学部, 助教 (70343457)
KAWASE Masami 松山大学, 薬学部, 教授 (20112641)
MIMAKI Yoshihiro 東京薬科大学, 薬学部, 教授 (90229790)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 口腔扁平上皮癌細胞 / 細胞死のタイプ / アポトーシス / オートファジー / 構造活性相関 / 環状α / β不飽和ケトン / 細胞間での感受性の差 / 環状α,β-不飽和ケトン / 細胞のタイプ / ベンズアルデヒド誘導体 / ビタミンK_2 / プレニルアルコール |
|---|
| Research Abstract |
Vitamin K_2 and imidazoles showed weak tumor-specificity against human oral squamous cell carcinoma cell lines, whereas benzaldehyde, tetraisoquinolines and cyclic α,β-unsaturated ketones showed much higher tumor-specificity. These compounds induced autophagic cell death characterized by destruction of mitochondrial structure, but autophagy inhibitors failed to prevent the induced cell death. There was a good correlation between their cytotoxicity and chemical descriptors such as hydrophobicity, surface area, volume and width of the molecules.
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