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Triggering receptor expressed on myeloid cell-like transcript 2(TLT-2)is a counter-receptor for B7-H3 and enhances T cell responses

Research Project

Project/Area Number 19592168
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

HASHIGUCHI Masaaki  Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 助教 (20372443)

Co-Investigator(Kenkyū-buntansha) AZUMA Miyuki  東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (90255654)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords免疫 / 感染 / 炎症 / 補助シグナル / T細胞 / アレルギー / 破骨細胞
Research Abstract

x補助シグナル分子は細胞間相互作用において正あるいは負に応答を制御することが知られている. 本研究により, これまで詳細な機能が不明であったB7ファミリー分子B7-H3のカウンターレセプターがTremファミリーに属するTrem-like transcript 2(Tlt2, Treml2)であることを同定した. さらに, B7-H3とTlt2の会合はT細胞応答を亢進し, また接触性アレルギーを亢進することを明らかにした.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (6 results)

All 2008 2007

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses2008

    • Author(s)
      Hashiguchi, M., Kobori, H., Ritprajak, P., Kamimura, Y., Kozono, H., Azuma, M.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 105

      Pages: 10495-10500

    • Related Report
      2008 Final Research Report
  • [Journal Article] Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2)is acounter-receptor for B7-H3 and enhances T cell responses2008

    • Author(s)
      Hashiguchi, M., Kobori, H., Ritprajak, P., Kamimura, Y., Kozono, H., Azuma, M.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 105

      Pages: 10495-10500

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Triggering receptor expressed on myeloid cell-like transcript 2(TLT-2)is a counter-receptor for B7-H3 and enhances T cell responses2008

    • Author(s)
      Hashiguchi, M., Kobori, H., Ritprajak, P., Kamimura, Y., Azuma, M.
    • Organizer
      日本免疫学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2)is acounter-receptor for B7-H3 and enhances T cell responses2008

    • Author(s)
      Hashiguchi, M., Kobori, H., Ritprajak, P., Kamimura, Y., Azuma, M.
    • Organizer
      日本免疫学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-03-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] B7-H3 upregulates immune responeses through the ligation with the B7-H3 receptor2007

    • Author(s)
      Hashiguchi, M., Kobori, H., Ritprajak,P., Piao, J., Azuma, M.
    • Organizer
      American Association of Immunologist
    • Place of Presentation
      Miami Beach, Florida, USA
    • Year and Date
      2007-05-20
    • Related Report
      2008 Final Research Report
  • [Presentation] B7-H3 upregulates immune responeses through the ligation with the B7-H3 receptor2007

    • Author(s)
      M. Hashiguchi, H. Kobori, P, Ritprajak, J. Piao, M. Azuma
    • Organizer
      American Association of Immunologist
    • Place of Presentation
      Miami Beach, Florida,USA
    • Year and Date
      2007-05-20
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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