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Development of pathogenesis based therapy for xerostomia

Research Project

Project/Area Number 19592177
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionKyushu Dental College

Principal Investigator

TANAKA Tatsurou  Kyushu Dental College, 歯学部, 講師 (50326469)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords口腔乾燥症 / MRI / sialography / 唾液腺 / 機能 / 治療 / 唾液 / シェーグレン症候群 / クエン酸
Research Abstract

We reported the functional differences between the parotid and submandibular glands in the healthy volunteer using dynamic MR sialography. In addition, Differences between the parameters of dynamic MR sialography were elucidated between the healthy volunteer and the patient with dry mouth as chief complaint. The maximum area of the detectable ducts in the patient group was significantly smaller, while the change in detectable duct area was significantly lower. In other words, our study suggests that dynamic MR sialographic images and data can be useful in the diagnosis of patients with dry mouth as chief complaint.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (48 results)

All 2009 2008 2007 Other

All Journal Article (26 results) (of which Peer Reviewed: 23 results) Presentation (18 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Small salivary gland size in patients with xerostomia of unknown etiology.2009

    • Author(s)
      Ono K, Tanaka T, Inoue H, Ansai T, Wakasugi-Sato, Muraoka K, Yokota M, Takehara T, Morimoto Y, Inenaga K.
    • Journal Title

      Arch Oral Biol 54

      Pages: 369-73

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between the curative effects of carbamazepine administration and the neurovascular compression volume of the trigeminal nerve measured using magnetic resonance cisternography.2009

    • Author(s)
      Tanaka T, Sakamoto E, Shiiba S, Oda M, Kito S, Wakasugi-Sato N, Matsumoto-Takeda S, Imamura Y, Nakanishi O, Morimoto Y.
    • Journal Title

      Clin J Pain 25

      Pages: 752-9

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Importance of clinical features and CT findings in numb chin syndrome: report of two cases.2009

    • Author(s)
      Yoshioka I, Shiiba S, Tanaka T, Nishikawa T, Sakamoto E, Kito S, Oda M, Wakasugi-Sato N, Matsumoto-Takeda S, Kagawa S, Nakanishi O, Tominaga K, Morimoto Y.
    • Journal Title

      J Am Dent Assoc 140

      Pages: 550-4

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between the curative effects of carbamazepine administration and the neurovascular compression volume of the trigeminal nerve measured using magnetic resonance cisternography2009

    • Author(s)
      Tanaka T, Sakamoto E, Shiiba S, Oda M, Kito S, Wakasugi-Sato N, Matsumoto-Takeda S, Imamura Y, Nakanishi O, Morimoto Y
    • Journal Title

      Clin J Pain 25

      Pages: 752-759

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Small salivary gland size in patients with xerostomia of unknown etiology2009

    • Author(s)
      Ono K, Tanaka T, Inoue H, Ansai T, Wakasugi-Sato, Muraoka K, Yokota M, Takehara T, Morimoto Y, Inenaga K
    • Journal Title

      Arch Oral Biol 54

      Pages: 369-373

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Importance of clinical features and CT findings in numb chin syndrome : report of two cases2009

    • Author(s)
      Yoshioka I, Shiiba S, Tanaka T, Nishikawa T, Sakamoto E, Kito S, Oda M, Wakasugi-Sato N, Matsumoto-Takeda S, Kagawa S, Nakanishi O, Tominaga K, Morimoto Y
    • Journal Title

      J Am Dent Assoc 140

      Pages: 550-554

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      Tanaka T, Konoo T, Yoshioka I, Habu M, Kito S, Kodama M, Oda M, Wakasugi-Sato N, Matsumoto S, Kagawa S, Terashita M, Tominaga K, Morimoto Y
    • Journal Title

      In RESEARCH ADVANCES IN ORAL DISEASES(GLOBAL RESEARCH NETWORK)

      Pages: 15-22

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Usefulness of CT scan images for planning thebone cut for Intra-oralVertical Ramus Osteotomy.2008

    • Author(s)
      Yoshioka I, Tanaka T, Oda M, Kodama M, Habu M, Kito S, Okabe S, Wakasugi-Sato N, Kuroiwa H, Tominaga K, Morimoto Y.
    • Journal Title

      Journal of Maxillofacial & Oral Surgery 7

      Pages: 245-250

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of the relationship between the mandibular cortex on panoramic radiographs and the risk of bone fracture and vascular disease in 80-year-olds2008

    • Author(s)
      Okabe S, Morimoto Y, Ansai T, Yoshioka I, Tanaka T, Taguchi A, Kito S, Wakasugi-Sato N, Oda M, Kuroiwa H, Ohba T, Awano S, Takata Y, Takehara T.
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 106

      Pages: 433-42

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic magnetic resonance sialography for patients with xerostomia.2008

    • Author(s)
      Tanaka T, Ono K, Ansai T, Yoshioka I, Habu M, Tomoyose T, Yamashita Y, Nishida I, Oda M, Kuroiwa H, Wakasugi-Sato N, Okabe S, Kito S, Takahashi T, Tominaga K, Inenaga K, Morimoto Y.
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 106

      Pages: 115-23

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic MR sialography for patients with xerostomia2008

    • Author(s)
      Tanaka T, Ono K, Ansai T, Yoshioka I, Habu M, Tomoyose T, Yamashita Y, Nishida I, Oda M, Kuroiwa H, Wakasugi-Sato N, Okabe S, Kito S, Takahashi T, Tominaga K, Inenaga K, Morimoto Y
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106

      Pages: 939-947

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Usefulness of CT scan images for planning the bone cut for intra-oral vertical ramus osteotomy2008

    • Author(s)
      Yoshioka I, Tanaka T, Oda M, Kodama M, Habu M, Kito S, Okabe S, Wakasugi-Sato N, Kuroiwa H, Tominaga K, Morimoto Y
    • Journal Title

      J Maxillofac Oral Surg 7

      Pages: 245-250

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of the relationship between the mandibular cortex on panoramic radiographs and the risk of fractures and vascular diseases in 80-year-olds2008

    • Author(s)
      Okabe S, Morimoto Y, Ansai T, Yoshioka I, Tanaka T, Taguchi A, Kito S, Wakasugi-Sato N, Oda M, Kuroiwa H, Ohba T, Awano S, Takata Y, Takehara T
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106

      Pages: 433-442

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic MR sialographyを用いた唾液腺の機能評価2008

    • Author(s)
      田中達朗, 若杉奈緒, 岡部幸子, 鬼頭慎司, 森本泰宏
    • Journal Title

      北九医工誌 18

      Pages: 35-38

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Relationship between cortical bone formation on mandibular condyles and alternation of the magnetic resonance signals characteristic during growth.2007

    • Author(s)
      Morimoto Y, Konoo T, Tominaga K, Tanaka T, Yamaguchi K, Fukuda J, Ohba T.
    • Journal Title

      Am J Orthod Dentofacial Orthop. 131

      Pages: 473-80

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship of chewing-stimulated whole saliva flow rate and salivary gland size.2007

    • Author(s)
      Ono K, Inoue H, Masuda W, Morimoto Y, Tanaka T, Yokota M, Inenaga K.
    • Journal Title

      Arch Oral Biol. 52

      Pages: 427-431

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional evaluations of the parotid and submandibular glands using dynamic MR sialography.2007

    • Author(s)
      Tanaka T, Ono K, Habu M, Inoue H, Tominaga K, Okabe S, Kito S, Yokota M, Fukuda J, Inenaga K, Morimoto Y.
    • Journal Title

      Dentomaxillofac Radiol 36

      Pages: 218-223

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in temporomandibular disc position during growth in young Japanese.2007

    • Author(s)
      Tominaga K, Konoo T, Morimoto Y, Tanaka T, Habu M, Fukuda J.
    • Journal Title

      Dentomaxillofac Radiol 36

      Pages: 397-401

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intraoperative surgical clearance confirmation of tongue carcinomas using ultrasound.2007

    • Author(s)
      Tominaga K, Yamamoto K, Khanal A, Morimoto Y, Tanaka T, Kodama M, Fukuda J.
    • Journal Title

      Dentomaxillofac Radiol 36

      Pages: 409-411

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic MR sialographyを用いた唾液腺の機能評価2007

    • Author(s)
      田中達朗、若杉奈緒、岡部幸子、鬼頭慎司、森本泰宏
    • Journal Title

      北九医工誌 16

      Pages: 23-26

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional evaluations of the parotid and submandibular glands using dynamic MR sialography2007

    • Author(s)
      Tanaka T, Ono K, Habu M, Inoue H, Tominaga K, Okabe S, Kito S, Yokota M, Fukuda J, Inenaga K, Morimoto Y
    • Journal Title

      Dentomaxillofac Radiol 36

      Pages: 218-223

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship of chewing-stimulated whole saliva flow rate and salivary gland size2007

    • Author(s)
      Ono K, Inoue H, Masuda W, Morim oto Y, Tanaka T, Yokota M, Inenaga K
    • Journal Title

      Arch Oral Biol 52

      Pages: 427-431

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Change of temporomandibular disk position during growth in young Japanese2007

    • Author(s)
      Tominaga K, Konoo T, Morimoto Y, Tanaka T, Habu M, Fukuda J
    • Journal Title

      Dentomaxillofac Radiol 36

      Pages: 409-411

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intraoperative surgical clearance conformation of tongue carcinomas using ultrasonography2007

    • Author(s)
      Tominaga K, Yamamoto K, Khanal A, Morimoto Y, Tanaka T, Kodama M, Fukuda J
    • Journal Title

      Dentomaxillofac Radiol 36

      Pages: 397-401

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between cortical bone formation on mandibular condyles and alternation of the magnetic resonance signals characteristic during growth2007

    • Author(s)
      Morimoto Y, Konoo T, Tominaga K, Tanaka T, Yamaguchi K, Fukuda J, Ohba T
    • Journal Title

      Am J Orthod Dentofacial Orthop 131

      Pages: 473-480

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic MR sialography for patients with Sjogren syndrome.

    • Author(s)
      Tanaka T, Yoshioka I, Kagawa S, Oda M, Wakasugi-Sato N, Matsumoto S, Kito S, Morimoto Y.
    • Journal Title

      The 7th Asian Congress of Oral and Maxillo-Facial Radiology, Nara 20081100

    • Related Report
      2009 Final Research Report
  • [Presentation] 口腔乾燥症患者に対するDynamic MR sialographyの有用性2009

    • Author(s)
      田中達朗, 鬼頭慎司, 若杉奈緒, 松本忍, 小田昌史, 内田朱美, 広松辰巳, 森本泰宏
    • Organizer
      日本歯科放射線学会第14回臨床画像大会
    • Place of Presentation
      北海道大学
    • Year and Date
      2009-10-24
    • Related Report
      2009 Final Research Report
  • [Presentation] 三叉神経痛治療法の選択と予後判定におけるMR cisternographyの有効性2009

    • Author(s)
      田中達朗, 鬼頭慎司, 若杉奈緒, 松本忍, 小田昌史, 内田朱美, 廣松辰己, 森本泰宏
    • Organizer
      第50回日本歯科放射線学会総会・学術大会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] 顎変形症患者における下顎枝垂直骨切り術(IVRO)術前検査におけるX線CT画像の有用性2009

    • Author(s)
      田中達朗, 吉岡泉, 小田昌史, 鬼頭慎司, 若杉奈緒, 松本忍, 内田朱美, 廣松辰己, 森本泰宏
    • Organizer
      第22回日本口腔診断学会総会
    • Place of Presentation
      神奈川
    • Related Report
      2009 Annual Research Report
  • [Presentation] 口腔乾燥症患者に対するDynamic MR sialographyの有用性2009

    • Author(s)
      田中達朗, 鬼頭慎司, 若杉奈緒, 松本忍, 小田昌史, 内田朱美, 広松辰巳, 森本泰宏
    • Organizer
      日本歯科放射線学会 第14回臨床画像大会
    • Place of Presentation
      北海道
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dynamic MR sialography for patients with Sjogren syndrome.2008

    • Author(s)
      Tanaka T, Yoshioka I, Kagawa S, Oda M, Wakasugi-Sato N, Matsumoto S, Kito S, Morimoto Y.
    • Organizer
      The 7th Asian Congress of Oral and Maxillo-Facial Radiology, Nara
    • Related Report
      2009 Final Research Report
  • [Presentation] シェーグレン症候群患者に対するDynamic MR sialographyの有用性2008

    • Author(s)
      田中達朗, 小田昌史, 若杉奈緒, 松本忍, 鬼頭慎司, 森本泰宏
    • Organizer
      日本歯科放射線学会第49回学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 口腔乾燥症治療(唾液腺洗浄法)の効果予測におけるDynamic MR sialographyの可能性2008

    • Author(s)
      森本泰宏, 土生学, 友寄泰樹, 吉岡泉, 尾崎由衛, 小野堅太郎, 田中達朗, 冨永和宏, 安細敏弘, 柿木保明, 高橋哲, 稲永清敏
    • Organizer
      第68回九州歯科学会総会
    • Place of Presentation
      北九州
    • Related Report
      2009 Final Research Report
  • [Presentation] Dynamic MR sialography for patients with Sjogren syndrome2008

    • Author(s)
      Tanaka T, Yoshioka I, Kito S, Matumoto S, Wakasugi-Sato N, Oda M, Kagawa S, Ono Y, Shiki K, Momozono A, Morimoto Y
    • Organizer
      The 7th Asian Congress of Oral and Maxillofacial Radiology
    • Place of Presentation
      Nara
    • Related Report
      2008 Annual Research Report
  • [Presentation] 三叉神経痛治療法の選択と予後判定におけるMR画像の有効性2008

    • Author(s)
      田中達朗, 椎葉俊司, 坂本英治, 鬼頭慎司, 松本 忍, 若杉奈緒, 小田昌史, 仲西 修, 森本泰宏
    • Organizer
      第21回日本口腔診断学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] Alteration of the magnetic resonance imaging signals characteristic of mandibular condyles in growing children.2007

    • Author(s)
      Tanaka T, Okabe S, Yoshioka I, Tominaga K, Konoo T, Kito S, Morimoto Y
    • Organizer
      16th IADMFR, Beijing, China
    • Related Report
      2009 Final Research Report
  • [Presentation] Functional evaluation of parotid glands using dynamic MR sialography with citric acid stimulation2007

    • Author(s)
      Morimoto Y, Okabe S, Yoshioka I, Ono K, Tanaka T, Kito S, Inenaga K
    • Organizer
      The 16th International Congress of Dentomaxillofacial Radiology, Beijing, China
    • Related Report
      2009 Final Research Report
  • [Presentation] 成長期顎関節のMRI所見の変化.2007

    • Author(s)
      田中達朗, 岡部幸子, 鬼頭慎司, 森本泰宏
    • Organizer
      第48回日本歯科放射線学会総会・学術大会
    • Place of Presentation
      大宮
    • Related Report
      2009 Final Research Report
  • [Presentation] MR sialographyを用いた唾液腺機能の評価2007

    • Author(s)
      田中達朗, 若杉奈緒, 小田昌史, 岡部幸子, 鬼頭慎司, 森本泰宏
    • Organizer
      第12回臨床画像大会
    • Place of Presentation
      柏
    • Related Report
      2009 Final Research Report
  • [Presentation] 正常ボランティアにおけるDynamic MR sialography2007

    • Author(s)
      岡部幸子, 田中達朗, 鬼頭慎司, 森本泰宏
    • Organizer
      第48回日本歯科放射線学会総会・学術大会
    • Place of Presentation
      大宮
    • Related Report
      2009 Final Research Report
  • [Presentation] 排泄機能を指標にした唾液腺病変の診断に対する新たなアプローチ2007

    • Author(s)
      森本泰宏, 小野堅太郎, 田中達朗, 冨永和宏, 安細敏弘, 柿木保明, 高橋哲, 稲永清敏
    • Organizer
      第67回九州歯科学会総会
    • Place of Presentation
      北九州
    • Related Report
      2009 Final Research Report
  • [Presentation] Alteration of the magnetic resonance imaging signals characteristic of mandibular condyles in growing children2007

    • Author(s)
      Tanaka T. Okabe S, Yoshioka I, Tominaga K, Konoo T, Kito S, Morimoto Y
    • Organizer
      The 16th International Congress of Dentomaxillofacial Radiology
    • Place of Presentation
      Beijing,China
    • Related Report
      2007 Annual Research Report
  • [Presentation] 成長期顎関節のMRI所見の変化2007

    • Author(s)
      田中 達朗, 岡部 幸子, 鬼頭 慎司, 森本 泰宏
    • Organizer
      第48回日本歯科放射線学会総会・学術大会
    • Place of Presentation
      大宮
    • Related Report
      2007 Annual Research Report
  • [Presentation] MR sialographyを用いた唾液腺機能の評価2007

    • Author(s)
      田中 達朗, 若杉 奈緒, 小田 昌史, 岡部 幸子, 鬼頭 慎司, 森本 泰宏
    • Organizer
      第12回日本歯科放射線学会臨床画像大会
    • Place of Presentation
      柏
    • Related Report
      2007 Annual Research Report
  • [Book] Double contour-like structures", characteristic magnetic resonance signals on mandibular condyles seen during child growth.2009

    • Author(s)
      Tanaka T, Konoo T, Yoshioka I, Habu M, Kito S, Kodama M, Oda M, Wakasugi-Sato N, Matsumoto S, Kagawa S, Terashita M, Tominaga K, Morimoto Y
    • Publisher
      In RESEARCH ADVANCES IN ORAL DISEASES
    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www2.kyu-dent.ac.jp/depart/radiology/study.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www2.kyu-dent.ac.jp/depart/radiology/study.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www2.kyu-dent.ac.jp/depart/radiplogy/study.html

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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