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Clarification of molecular mechanism that deteriorates periodontitis with alveolar bone resorption by nicotine and lipopolysaccharide.

Research Project

Project/Area Number 19592182
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionNihon University

Principal Investigator

MAENO Masao  Nihon University, 歯学部, 教授 (60147618)

Co-Investigator(Kenkyū-buntansha) SUZUKI Naoto  日本大学, 歯学部, 准教授 (10226532)
田中 秀樹  日本大学, 歯学部, 専修研究員 (90434076)
田邊 奈津子  日本大学, 歯学部, 助教 (10409097)
Co-Investigator(Renkei-kenkyūsha) TANABE Natsuko  日本大学, 歯学部, 助教 (10409097)
TANAKA Hideki  日本大学, 歯学部, 専修研究員 (90434076)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords喫煙 / ニコチン / リボ多糖(LPS) / 骨芽細胞 / 破骨細胞 / ロスタグランジンE2 / マトリックス金属プロテアーゼ / リポ多糖 (LPS) / プロスタグランジンE_2 / プラスミノーゲンアクチベーター / 歯周病 / リポ多糖(LPS) / シクロオキシゲナーゼ
Research Abstract

ニコチンとLPSが,歯肉上皮を浸透して骨芽細胞および破骨細胞前駆細胞に作用することを想定し,本研究を企図した。ニコチンとLPSは,骨芽細胞に対して破骨細胞形成を促進する種々の因子の発現を増加させるとともに,骨芽細胞による類骨層のタンパク代謝を分解系に傾けた。破骨細胞前駆細胞に対しては,骨基質タンパク分解酵素の発現増加を介して骨吸収能を上昇させた。これらの結果,歯槽骨吸収が促進されて歯周病が増悪する可能性が示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (38 results)

All 2009 2008 2007

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (28 results)

  • [Journal Article] IL-Iβ stimulates the expression of prostaglandin receptor EP4 in human chondrocytes by increasing production of prostaglandin E22009

    • Author(s)
      Watanabe Y, Suzuki N, Tanabe N, Maeno M, 他5名
    • Journal Title

      Connect Tissue Res in press

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of nicotine and lipopolysaccharide on the expression of matrix metalloproteinases, plasminogenactivators, and their inhibitors in human osteoblasts2009

    • Author(s)
      Katono T, Tanabe N, Tanaka H, Suzuki N, Maeno M, 他5名
    • Journal Title

      Arch Oral Biol 54(2)

      Pages: 146-155

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of nicotine and lipopolysaccharide on the expression of matrix metalloproteinases, plasminogen activators, and their inhibitors in human osteoblasts.2009

    • Author(s)
      Tomoko Katono
    • Journal Title

      Archives of Oral Biology 54

      Pages: 146-155

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-1β stimulates the expression of prostaglandin receptor EP4 in human chondrocytes by increasing production of prostaglandin E_2.2009

    • Author(s)
      Yusuke Watanabe
    • Journal Title

      Connective Tissue Research (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sodium butyrate stimulates mineralized nodule formation and osteoprotegerin expression by human osteoblasts2008

    • Author(s)
      Katono T, Tanabe N, Suzuki N, Maeno M, '他4名
    • Journal Title

      Arch Oral Biol 53(10)

      Pages: 903-909

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sodium butyrate stimulates mineralized nodule formation and osteoprotegerin expression by human osteoblasts,2008

    • Author(s)
      Tomoko Katono
    • Journal Title

      Archives of Oral Biology (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of IL-6 and soluble IL-6 receptor on the expression of cartilage matrixproteins in human chondrocytes2007

    • Author(s)
      Namba A, Suzuki N, Maeno M, 他6名
    • Journal Title

      Connect Tissue Res 48(5)

      Pages: 263-270

    • NAID

      10021232531

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lipopolysaccharide enhances the production of nicotine-induced prostaglandin E2 by an increase in cyclooxygenase-2 expression in osteoblasts2007

    • Author(s)
      Shoji M, Tanabe N, Suzuki N, Maeno M, 他4名
    • Journal Title

      Acta Biochim Biophys Sin 39(3)

      Pages: 163-172

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lipopolysaccharide enhances the production of nicotine-induced prostaglandin E_2 by an increase in cyclooxygenase-2 expression in osteoblasts.2007

    • Author(s)
      Maiko Shoji
    • Journal Title

      Acta Biochimica et Biophysica Sinica 39

      Pages: 163-172

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of IL-6 and soluble IL-6 receptor on the expression of cartilage matrix proteins in human chondrocytes.2007

    • Author(s)
      Aki Namba
    • Journal Title

      Connective Tissue Research 48

      Pages: 263-270

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] IL-1BはPGE2産生を介して軟骨細胞のEP4受容体発現を促進する2008

    • Author(s)
      渡部悠介, 他6名
    • Organizer
      第26回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2008-10-29
    • Related Report
      2008 Final Research Report
  • [Presentation] IL-1βはPGE_2産生を介して軟骨細胞のEP4受容体発現を促進する2008

    • Author(s)
      渡部悠介
    • Organizer
      第26回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場, 大阪
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] IL-17は破骨細胞の形成を抑制する2008

    • Author(s)
      北見聡, 他7名
    • Organizer
      第57回日本口腔衛生学会・総会
    • Place of Presentation
      大宮
    • Year and Date
      2008-10-04
    • Related Report
      2008 Final Research Report
  • [Presentation] ニコチンは破骨細胞のERKを介して酸産生酵素の発現を増加する2008

    • Author(s)
      田中秀樹, 他6名
    • Organizer
      第57回日本口腔衛生学会
    • Place of Presentation
      大宮
    • Year and Date
      2008-10-04
    • Related Report
      2008 Final Research Report
  • [Presentation] 骨芽細胞の骨基質タンパク代謝に及ぼすニコチンとリボ多糖の影響2008

    • Author(s)
      上遠野朋子, 他6名
    • Organizer
      第57回日本口腔衛生学会・総会
    • Place of Presentation
      大宮
    • Year and Date
      2008-10-04
    • Related Report
      2008 Final Research Report
  • [Presentation] 骨芽細胞の骨基質タンパク代謝に及ぼすニコチンとリポ多糖の影響.2008

    • Author(s)
      上遠野朋子
    • Organizer
      第57回日本口腔衛生学会・総会
    • Place of Presentation
      大宮ソニックシティ, 大宮
    • Year and Date
      2008-10-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] ニコチンは破骨細胞のERKを介して酸産生酵素の発現を増加する.2008

    • Author(s)
      田中秀樹
    • Organizer
      第57回日本口腔衛生学会・総会
    • Place of Presentation
      大宮ソニックシティ, 大宮
    • Year and Date
      2008-10-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] IL-17は破骨細胞の形成を抑制する.2008

    • Author(s)
      北見 聡
    • Organizer
      第57回日本口腔衛生学会・総会
    • Place of Presentation
      大宮ソニックシティ, 大宮
    • Year and Date
      2008-10-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] ニコチンは破骨細胞の炭酸脱水酵素II型の発現を増加させる2008

    • Author(s)
      田中秀樹, 他4名
    • Organizer
      第17回硬組織再生生物学会学術大会・総会
    • Place of Presentation
      徳島
    • Year and Date
      2008-08-30
    • Related Report
      2008 Final Research Report
  • [Presentation] ニコチンは破骨細胞の炭酸脱水酵素II型の発現を増加させる.2008

    • Author(s)
      田中秀樹
    • Organizer
      第17回硬組織再生生物学会学術大会・総会
    • Place of Presentation
      徳島文理大学, 徳島
    • Year and Date
      2008-08-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 酪酸が骨芽細胞による石灰化nodule形成と破骨細胞分化調節因子の発現に及ぼす影響2008

    • Author(s)
      上遠野朋子, 他3名
    • Organizer
      第81回日本細菌学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-03-24
    • Related Report
      2008 Final Research Report
  • [Presentation] 酷酸が骨芽細胞による石灰化nodule形成と破骨細胞分化調節因子の発現に及ぼす影響2008

    • Author(s)
      上遠野朋子
    • Organizer
      第81回日本細菌学会総会
    • Place of Presentation
      京都国際会議場,京都
    • Year and Date
      2008-03-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] ニコチンは破骨細胞の炭酸脱水酵素II型とカテプシンKの発現を増加させる2007

    • Author(s)
      田中秀樹, 他7名
    • Organizer
      第56回日本口腔衛生学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-10-04
    • Related Report
      2008 Final Research Report
  • [Presentation] 酪酸は骨芽細胞の石灰化nodule形成を促進し破骨細胞分化を抑制する2007

    • Author(s)
      上遠野朋子, 他7名
    • Organizer
      第56回日本口腔衛生学会
    • Place of Presentation
      東京
    • Year and Date
      2007-10-04
    • Related Report
      2008 Final Research Report
  • [Presentation] 酪酸は骨芽細胞の石灰化nodule形成を促進し破骨細胞分化を抑制する2007

    • Author(s)
      上遠野朋子
    • Organizer
      第56回日本口腔衛生学会・総会
    • Place of Presentation
      タワーホール船堀,東京
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] IL-6とsIL-6Rは軟骨細胞の分化を抑制し細胞外基質成分の産生を促進する2007

    • Author(s)
      難波亜希
    • Organizer
      第56回日本口腔衛生学会・総会
    • Place of Presentation
      タワーホール船堀,東京
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] ニコチンは破骨細胞の炭酸脱水酵素II型とカテプシンKの発現を増加させる2007

    • Author(s)
      田中秀樹
    • Organizer
      第56回日本口腔衛生学会・総会
    • Place of Presentation
      タワーホール船堀,東京
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] The effect of IL-6 and sIL-6R on the expression of cartilage matrix proteins2007

    • Author(s)
      Namba A, 他6名
    • Organizer
      JBMR 22. 29th ASBMR Annual Meeting
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2007-09-18
    • Related Report
      2008 Final Research Report
  • [Presentation] Nicotine and lipopolysaccharide stimulate the formation of osteoclast-like cellsby increasing macrophage colony-stimulating factor and prostaglandin E2 production by osteoblasts2007

    • Author(s)
      Tanaka H, 他7名
    • Organizer
      JBMR 22, 29th ASBMR Annual Meeting
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2007-09-18
    • Related Report
      2008 Final Research Report
  • [Presentation] Nicotine and lipopolysaccharide stimulate the formation of osteoclast-like cells by increasing macrophage colony-stimulating fator and prostaglandin E_2 production by osteoblasts.2007

    • Author(s)
      Hideki Tanaka
    • Organizer
      29th ASBMR Annual Meeting
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2007-09-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] The effect of IL-6 and sIL-6R on the expression of cartilage matrix proteins.2007

    • Author(s)
      Aki Namba
    • Organizer
      29th ASBMR Annual Meeting
    • Place of Presentation
      Honolulu, Hawai, USA
    • Year and Date
      2007-09-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] IL-6はsIL-6R存在下でヒト軟骨細胞による軟骨基質タンパク発現を増加する2007

    • Author(s)
      難波亜希
    • Organizer
      第49回歯科基礎医学会学術大会・総会
    • Place of Presentation
      北海道大学,札幌
    • Year and Date
      2007-08-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] IL-6はsIL-6R存在下でヒト軟骨細胞による軟骨基質タンパク発現を増加する2007

    • Author(s)
      難波亜希, 他4名
    • Organizer
      第49回歯科基礎医学会学術大会・総会
    • Place of Presentation
      札幌
    • Year and Date
      2007-07-19
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒト軟骨細胞の軟骨基質形成に及ぼすIL-6とslL-6Rの影響2007

    • Author(s)
      難波亜希
    • Organizer
      第25回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場,大阪
    • Year and Date
      2007-07-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] IL-6はsIL-6R存在下で軟骨細胞の分化を抑制し軟骨基質形成を促進する2007

    • Author(s)
      難波亜希, 他6名
    • Organizer
      第59回日本大学歯学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-05-19
    • Related Report
      2008 Final Research Report
  • [Presentation] 骨芽細胞の骨タンパク代謝におけるニコチンの影響2007

    • Author(s)
      上遠野朋子, 他5名
    • Organizer
      第59回日本大学歯学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-05-19
    • Related Report
      2008 Final Research Report
  • [Presentation] 骨芽細胞の骨タンパク代謝におけるニコチンの影響2007

    • Author(s)
      上遠野朋子
    • Organizer
      第59回日本大学歯学会総会
    • Place of Presentation
      日本大学歯学部,東京
    • Year and Date
      2007-05-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] IL-6はsIL-6R存在下で軟骨細胞の分化を抑制し軟骨基質形成を促進する2007

    • Author(s)
      難波亜希
    • Organizer
      第59回日本大学歯学会総会
    • Place of Presentation
      日本大学歯学部,東京
    • Year and Date
      2007-05-19
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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