| Project/Area Number |
19592184
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pathobiological dentistry/Dental radiology
|
|---|
| Research Institution | The Nippon Dental University |
|---|
Principal Investigator |
NASU Masanori The Nippon Dental University, 生命歯学部, 准教授 (50130688)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MITSUHASHI Fusako 日本歯科大学, 生命歯学部, 助教 (60187896)
|
|---|
| Project Period (FY) |
2007 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | amifostine / 放射線防護 / 唾液腺 / 血管内皮細胞 / X線 / 細胞樹立 / 免疫染色 / PCR / TEM / tube formation / マウス / アミフォスチン / 顎下腺 / 電顕オートラジオグラフィ / 耳下腺 / 光顕オートラジオグラフィ |
|---|
| Research Abstract |
Xerostomia is one of the most common complications during and after radiation therapy for head and neck cancer, because irreparable damage is caused to the salivary glands, which are included in the radiation fields. In order to prevent of the damage, the radioprotect drug, amifostine, is clinically used in USA.
.we have examined the effect of amifostine from the secretory ability of mice salivary gland acinar cells before radiation. We confirmed that the damage of the acinar cells of mice salivary glands were inhibited by amifostine during radiation compared to nonamifostine treated.
|
