The activation and regulation of protease-activated receptor in human dental pulp cells

• Project/Area Number: 19592212
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Nihon University
• Principal Investigator: HASHIZUME Hideki Nihon University, 松戸歯学部, 講師 (10256894)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: プロテアーゼレセプター / 細胞内カルシウム / アンタゴニスト / アゴニスト / PARs / プラスミン / 歯髄炎

Research Abstract

ヒト歯髄細胞(HDP)におけるプロテアーゼレセプター(PARs)の生理的・病態生理学的役割について研究し、以下の事項を明らかにした。1.HDP におけるPARs のCharacterization2.HDP におけるPARsの活性化調節機能3・4.PARs 活性化ペプチド・アンタゴニストがHDP のCa2+動態に及ぼす影響5.プラスミンがHDP のCa2+に及ぼす影響6.PAR-1 活性化と歯髄炎の関係

Research Products

• [Journal Article] Plasmin is involved in inflammation via protease-activated receptor-1 activation in human dental pulp (2008)
  • Author(s): N.Kamio, H.Hashizume, S.Nakao, K.Matsushima, H.Sugiya
  • Journal Title: Biochem. Pharmacol 15;75(10) Pages: 1974-1980
  • Peer Reviewed
• [Journal Article] Protein kinase C synergistically stimulates tumor necrosis factor-a-induced secretion of urokinase-type plasminogen activator in human dental pulp cells (2008)
  • Author(s): Hideki Hahsizume, Naoto Kamio, Sumi Nakao, Kiyoshi Matsushima and Hiroshi Sugiya
  • Journal Title: Journal of Physiological science 58(1) Pages: 83-86
  • Peer Reviewed
• [Journal Article] Plasmin is involved in inflammation via protease-activated receptor-1 activation in human dental pulp. (2008)
  • Author(s): N. Kamio, H. Hashizume, S. Nakao, K. Matsushima, H. Sugiya
  • Journal Title: Biochem Pharmacol 15 ; 75(10) Pages: 1974-1980
  • Peer Reviewed
• [Journal Article] IL-1b stimulates urokinase-type plasminogen activator expression and secretion in human dental pulp cells (2007)
  • Author(s): Naoto Kamio, Hideki Hahsizume, Sumi Nakao, Kiyoshi Matsushima and Hiroshi Sugiya
  • Journal Title: Journal of Physiological science 28(6) Pages: 315-322
  • Peer Reviewed
• [Journal Article] IL-lb stimulates urokinase-type plasminogen activator expression and secretion in human dental pulp cells (2007)
  • Author(s): Naoto Kamio, Hideki Hahsizume, Sumi Nakao, Kiyoshi Matsushima and Hiroshi Sugiya
  • Journal Title: Biomedical Research 28(6) Pages: 315-322
  • Peer Reviewed
• [Presentation] 培養ヒト歯根膜細胞におけるプロテアーゼ受容体PARs(protease-activated receptors)の発現について (2008)
  • Author(s): 室町幸一郎、神尾直人、橋爪英城、山浦賀弘、中尾寿美、松島潔
  • Organizer: 2008年秋季歯科保存学会,(第129回)
  • Place of Presentation: 富山
  • Year and Date: 2008-11-06
• [Presentation] 培養ヒト歯根膜細胞におけるプロテアーゼ受容体PARs(protease-activated receptors)の発現について (2008)
  • Author(s): 室町幸一郎, 神尾直人, 橋爪英城, 山浦賀弘, 中尾寿美, 松島潔
  • Organizer: 2008年 秋季 歯科保存学会(第129回)
  • Place of Presentation: 富山
  • Year and Date: 2008-11-06
• [Presentation] ヒト歯髄培養細胞におけるProtease Activity Reseptor-1を介した細胞内カルシウム動態とPGE2産生 (2007)
  • Author(s): 神尾直人、橋爪英城、武内ひとみ、三浦孝司、村上芳弘、松島潔
  • Organizer: 春季日本歯科保存学会(第126回)
  • Place of Presentation: 埼玉
  • Year and Date: 2007-06-08
• [Presentation] ヒト歯髄培養細胞におけるProtease Activity Reseptor-1を介した細胞内カルシウム動態とPGE_2産生 (2007)
  • Author(s): 神尾直人、橋爪英城、武内ひとみ、三浦孝司、村上芳弘、松島潔
  • Organizer: 日本歯科保存学会(第126回)
  • Place of Presentation: 埼玉 大宮
  • Year and Date: 2007-06-08