Development of the crude drug combination oral moisture for dry mouth

• Project/Area Number: 19592238
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 補綴理工系歯学
• Research Institution: Hiroshima University
• Principal Investigator: KAGAWA Kazuko Hiroshima University, 病院, 助教 (60432671)
• Co-Investigator(Kenkyū-buntansha): HONG Guang 東北大学, 大学院・歯学研究科, 助教 (70363083) ; 貞森 紳丞 広島大学, 大学院・医歯薬学総合研究科, 准教授 (40187167) ; 濱田 泰三 広島大学, 大学院・医歯薬学総合研究科, 教授 (50034244)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 口腔乾燥症 / 口腔内潤滑補助剤 / 生薬 / 潤滑補助剤

Research Abstract

This research aimed at development of the crude drug combination oral moisture for dry mouth. The significant differences were found among different materials in initial viscocity and adhesive strength of oral moisture. The values of adhesive strength increased after immersing significantly in each material. And the crude drug influenced distribution of AQP5 in salivary duct membrane of parotid positively. The results was suggest that the development of the crude drug combination oral moisture for dry mouth is possible.

Research Products

• [Journal Article] nfluence of PMMA polymer on the dynamic viscoelasticity and plasticizer leachability of tissue conditioner. (2010)
  • Author(s): G. Hong, T. Maeda, Y.A. Li, S. Sadamori, T. Hamada, H. Murata
  • Journal Title: Dent Mater J (n press)
  • Peer Reviewed
• [Journal Article] Effect of PMMA polymer on the dynamic viscoelasticity and plasticizer leachability of PEMA-based tissue conditioners (2010)
  • Author(s): G.Hong, T.Maeda, Y.A.Li, S.Sadamori, T.Hamada
  • Journal Title: Dent Mater J (Accept)
  • NAID: 10026564712
  • Peer Reviewed
• [Journal Article] The clinical application of silicone type resilient denture liner. (2009)
  • Author(s): Jin C., Hong G., Hamada T.
  • Journal Title: Dental Resource Guide 2009-03 Pages: 44-48
  • Peer Reviewed
• [Journal Article] The clinical application of hard direct denture liner. (2009)
  • Author(s): Jin C., Hong G., Hamada T.
  • Journal Title: Dental Resource Guide 2009-06 Pages: 34-41
  • Peer Reviewed
• [Journal Article] Influence of storage methods on the surface roughness of tissue conditioners. (2008)
  • Author(s): G. Hong, Y.A. Li, T. Maeda, W. Mizumachi, S. Sadamori, T. Hamada, H. MURATA
  • Journal Title: Dent Mater J 27(2) Pages: 153-158
  • NAID: 110006649443
  • Peer Reviewed
• [Journal Article] Influence of storage methods on the surface roughness of tissue conditioners (2008)
  • Author(s): Hong G.
  • Journal Title: Dent Mater J 27(2) Pages: 153-158
  • NAID: 110006649443
  • Peer Reviewed
• [Journal Article] Influence of storage methods on the surface roughness of tissue conditioners (2008)
  • Author(s): Hong G.
  • Journal Title: Dent Mater J 27(2)(in press)
  • NAID: 110006649443
  • Peer Reviewed
• [Journal Article] 義歯床用レジンの表面ぬれ性および抗真菌性に及ぼすセリシン液の影響 (2008)
  • Author(s): 洪 光
  • Journal Title: 広大歯誌 39(2)(in press)
  • NAID: 10021955777
  • Peer Reviewed
• [Journal Article] 義歯床用レジンの表面ぬれ性および抗菌性に及ぼすセリシン液の影響. (2007)
  • Author(s): 洪光, 李英愛, 前田武志, 濱田泰三
  • Journal Title: 広大歯誌 39(2) Pages: 121-126
  • Peer Reviewed
• [Presentation] セリシンパウダーの添加が粘膜調整材の表面ぬれに及ぼす影響 (2010)
  • Author(s): 洪光, ディリヌル・マイマイティサウット, 濱田泰三, 佐々木啓一
  • Organizer: 日本義歯ケア学会第2回学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-01-23
• [Presentation] 試作クリームタイプ義歯安定剤の理工学的性質について (2009)
  • Author(s): 洪光, 濱田泰三
  • Organizer: 第55回東北大学歯学会
  • Place of Presentation: 仙台
  • Year and Date: 2009-06-26
• [Presentation] 組成成分が粘膜調整材の理工学的性質に及ぼす影響.アルコールフリー試作粘膜調整材の動的粘弾性について (2009)
  • Author(s): 柄博紀, 洪光, 前田武志, 濱田泰三, 赤川安正, 野村雄二, 岡崎正之
  • Organizer: 第53回日本歯科理工学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-11
• [Presentation] アルコールフリー試作粘膜調整材の動的粘弾性について (2009)
  • Author(s): 柄博紀, 洪光, 前田武志
  • Organizer: 第53回日本歯科理工学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-11
• [Presentation] The influence of Sericin solution on wettability and antifungal effect of resin surface (2009)
  • Author(s): Hong G., Hamada T., Maeda T., Yuda S., Yamada H., Tsujimoto K., Sadamori S.
  • Organizer: The 3rd International Symposium for Interface Oral Health Science
  • Place of Presentation: Sendai
• [Presentation] PVM-MAおよびCMC含有量が試作クリームタイプ義歯安定剤の理工学的性質に及ぼす影響 (2008)
  • Author(s): 洪光, 林田健太郎, 前田武志, 水町亘, 柄博紀, 貞森紳丞, 村田比呂司
  • Organizer: 日本補綴歯科学会九州支部・中国・四国支部共同平成20年度学術大会
  • Place of Presentation: 別府
  • Year and Date: 2008-08-30
• [Presentation] 義歯安定剤の組成成分が初期粘度および粘着強さに及ぼす影響 (2008)
  • Author(s): 洪光, 林田健太郎, 村田比呂司, 前田武志, 水町亘, 濱田泰三
  • Organizer: 第117回日本補綴歯科学会学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-06-07
• [Presentation] 長時間作用型試作クリームタイプ義歯安定剤の物性について (2008)
  • Author(s): 林田健太郎, 洪光, 前田武志, 濱田泰三, 村田比呂司
  • Organizer: 第10回軟質義歯裏装材研究会
  • Place of Presentation: 広島
  • Year and Date: 2008-01-27
• [Presentation] Influence of Component on Viscoelasticity of Tissue Conditioners (2008)
  • Author(s): T. Maeda, G. Hong, W. Mizumachi, H. Tsuka, S. Sadamori, T. Hamada
  • Organizer: The 4th Sino-Japan Conference on Stomatology
  • Place of Presentation: Xi'an, China
• [Presentation] Effect of CMC Content on Mechanical Properties of Denture Adhesives. (2008)
  • Author(s): G. Hong
  • Organizer: The 4^<th> Sino-Japan Conference on Stomatology
  • Place of Presentation: Xi'an, China
• [Presentation] Influence of Component on Viscoelasticity of Tissue Conditioners. (2008)
  • Author(s): T. Maeda
  • Organizer: The 4^<th> Sino-Japan Conference on Stomatology
  • Place of Presentation: Xi'an, China
• [Presentation] 貞森紳丞:ホームリライナーの動的粘弾性の経時的変化について (2007)
  • Author(s): 前田武志, 洪光, 濱田泰三
  • Organizer: 第18回日本老年歯科医学総会
  • Place of Presentation: 札幌
  • Year and Date: 2007-06-22
• [Presentation] ホームリライナーの動的粘弾性の経時的変化について (2007)
  • Author(s): 前田 武志
  • Organizer: 第18回日本老年歯科医学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2007-06-22
• [Presentation] 水溶性高分子の含有量が義歯安定剤の粘度および粘着力に及ぼす影響 (2007)
  • Author(s): 林田健太郎, 洪光, 李英愛, 前田武志, 水町亘, 濱田泰三, 村田比呂司
  • Organizer: 第40回広島大学歯学会総会
  • Place of Presentation: 広島
  • Year and Date: 2007-06-16
• [Presentation] 義歯安定剤の組成が粘度および粘着力の経時的変化に及ぼす影響 (2007)
  • Author(s): 洪光, 村田比呂司, 前田武志, 濱田泰三
  • Organizer: 第49回日本歯科理工学会学術講演会
  • Place of Presentation: 札幌
  • Year and Date: 2007-05-13
• [Presentation] 長時間作用型試作クリームタイプ義歯安定剤の物性について (2007)
  • Author(s): 林田 健太郎
  • Organizer: 第10回軟質義歯裏装材研究会
  • Place of Presentation: 広島
  • Year and Date: 2007-01-27