| Project/Area Number |
19592245
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KAWANO Fumiaki The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 教授 (60195120)
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| Co-Investigator(Kenkyū-buntansha) |
HAMADA Kenichi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (00301317)
OHISH Mika 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (50263851)
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| Research Collaborator |
SEKINE Kazumitu 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 生体材料 / 硬組織代替材料 / 骨補填材 / 骨再生工学 / セラミックス / リン酸三カルシウム / HAPセメント / 生細胞数 / Sr-HAP / 擬似体液中 / MC3T3-E1 / DNA変化量 / 細胞毒性 / 塩化ストロンチウム水溶液 / 硬化時間 / 溶解速度 / pH / 培養試験 / α-TCP / Sr-HAP結晶 / 溶解性 / XRD / SrCO_3 / DTS |
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| Research Abstract |
The purpose of this study is to evaluate the strength and other properties of CPC containing Sr and carbonate, and to show its superiority to current CPC.
The DTS of set cements containing SrCO_3 were significantly lower than that of non-Sr-containing CPC. The solubility of set cements using 5%SrCO_3 was twice those of set cements without SrCO_3. From histological observations implanted for 1 week, inflammatory macrophages and osteoclast cells migrated into the cavity. Results implanted for 4 weeks showed a small amount of new bone was observed, which covered the cavity. These processes were observed earlier in the group using O%SrCO_3 than in the control group. We have developed Sr-containing CPC with high solubility, which showed several advantages as a bone replacing material.
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