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Application of bisphosphonate-immobilized titanium fiber as a three-dimensional scaffold

Research Project

Project/Area Number 19592260
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionNihon University

Principal Investigator

HAYAKAWA Tohru  Nihon University, 松戸歯学部, 准教授 (40172994)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsビスフォスフォネート / チタンファイバー / 3次元スキャホールド / 分子プレカーサー法 / 炭酸含有アパタイト / 薄膜コーティング / ゲル / 骨形成 / ビスワォスフォネート
Research Abstract

本研究では,分子プレカーサー法を用いて炭酸含有アパタイト(CA)薄膜コーティングを施したチタン(Ti)ファイバーに,骨粗鬆症の治療薬であるビスフォスフォネート(BP)を固定化し,3次元スキャホールドとしての有効性について検討した.BP固定化チタンファイバーはファイバー内部での骨形成が良好に起こっており,ファイバー内部への骨侵入度も優れていた.また,BP濃度により,CA薄膜コーティングTi ファイバー周囲にBPゲルを形成でき,ドラッグデリバリーシステムへの応用などが考えられた.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (30 results)

All 2009 2008 2007 Other

All Journal Article (22 results) (of which Peer Reviewed: 22 results) Presentation (8 results)

  • [Journal Article] Hydrogel formation of bisphosphonate around apatite coated titanium web2009

    • Author(s)
      Tohru Hayakawa, Tadao Fukushima, Takeshi Wada, Masao Yoshinari, Mitsunobu Sato
    • Journal Title

      J Oral Tissue Engin 6

      Pages: 189-193

    • NAID

      130004941155

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of apatite crystallinity in porous PLGA/apatite composite scaffold on cortical bone response2009

    • Author(s)
      Tohru Hayakawa, Chihiro Mochizuki, (他6名,1番目)
    • Journal Title

      J Hard Tissue Biol 18

      Pages: 7-12

    • NAID

      10025927525

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pre-intercalated DNA/Lipid/PLGA film as a drug carrier2008

    • Author(s)
      Minoru Kawaguchi, Tadao Fukushima, Tohru Hayakawa, Yusuke Inoue, Jun Ohno
    • Journal Title

      J Oral Tissue Engin 6

      Pages: 97-105

    • NAID

      110007043748

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complexation of DNA with cationic polyamino acid for biomaterial purposes2008

    • Author(s)
      Tadao Fukushima, Tohru Hayakawa, (他7名,3番目)
    • Journal Title

      J Oral Tissue Engin 6

      Pages: 24-32

    • NAID

      110007004836

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene Expression Monitoring in osteoblasts on Fibronectin Derived Peptide Coated Titanium2008

    • Author(s)
      Nobuyuki Yamamichi, Tohru Hayakawa, (他5名,6番目)
    • Journal Title

      Dent Mater J 27

      Pages: 744-750

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Conformational analysis of bisphosphonate/calcium complex2008

    • Author(s)
      Sen-ichi Suzuki, Tohru Hayakawa, Naoto Kamasaki, Hiroyuki Okada, Hirotsugu Yamamoto
    • Journal Title

      Int J Oral-Med Sci 7

      Pages: 45-49

    • NAID

      130000411393

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene Expressions in Osteoblasts on Fibronectin and Its Peptide (GRGDSP)-coated Titanium2008

    • Author(s)
      Tohru Hayakawa, Haruhiko Tsutsumi, Nobuyuki Yamamichi, Yoshimitsu Abiko
    • Journal Title

      医学と生物学 152

      Pages: 286-291

    • NAID

      40016149290

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of thin carbonate-containing apatite (CA) coating of titanium fiber mesh on trabecular bone response2008

    • Author(s)
      Tohru Hayakawa, Kenichi Takahashi, (他5名,1番目)
    • Journal Title

      J Mater Sci : Mater Med 19(5)

      Pages: 2087-2096

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Baculoviral inhibitor of apotosis repeat-containing gene expression in osteoblasts on fibronectin derived peptide coated titanium2008

    • Author(s)
      Watanabe Nobuyuki, Kamolparn Pugdee, Hayakawa Tohru, Abiko Yoshimitsu
    • Journal Title

      日口腔インプラント誌 21

      Pages: 1-6

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Baculoviral inhibitor of apotosis repeat-containing gene expression in osteoblasts on fibronectin derived peptide coated titanium2008

    • Author(s)
      Watanabe Nobuyuki
    • Journal Title

      日本口腔インプラント学会誌 21

      Pages: 1-6

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of thin carbonate-containing apatite (CA) coating of titanium fiber mesh on trabecular bone response2008

    • Author(s)
      Tohru Hayakawa
    • Journal Title

      Journal of Materials Science : Materials in Medicine. 19

      Pages: 2087-2096

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene Expressions in Osteoblasts on Fibronectin and Its Peptide (GRGDSP) -coated Titanium2008

    • Author(s)
      Tohru Hayakawa
    • Journal Title

      医学と生物学 152

      Pages: 286-291

    • NAID

      40016149290

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conformational analysis of bisphosphonate/calcium complex2008

    • Author(s)
      Sen-ichi Suzuki
    • Journal Title

      The International Journal of Oral-Medical Science 7

      Pages: 744-750

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complexation of DNA with cationic polyamino acid for biomaterial purposes2008

    • Author(s)
      Tadao Fukushima
    • Journal Title

      Journal of Oral Tissue Engineering 6

      Pages: 24-32

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pre-intercalated DNA/Lipid/PLGA film as a drug carrier2008

    • Author(s)
      Minoru Kawaguchi
    • Journal Title

      Journal of Oral Tissue Engineering 6

      Pages: 97-105

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation and tissue response of lipid-coated b-FGF2007

    • Author(s)
      Tohru Hayakawa, Tadao Fukushima, Minoru Kawaguchi, Yusuke Inoue
    • Journal Title

      J Oral Tissue Engin 5

      Pages: 96-103

    • NAID

      110006571215

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Drug Binding and Releasing Characteristics of DNA/lipid/PLGA film2007

    • Author(s)
      Tadao Fukushima, Minoru Kawaguchi, Tohru Hayakawa, Shoji Takeda, Yusuke Inoue, Jun Ohno, Kunihisa Taniguchi
    • Journal Title

      Dent Mater J 26

      Pages: 854-860

    • NAID

      110006557236

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Drug Binding and Releasing Characteristics of DNA/lipid/PLGA film2007

    • Author(s)
      Tadao Fukushima
    • Journal Title

      Dental Materials Journal 26

      Pages: 854-860

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] タンパク質固定化GTRメンブレンへのヒト歯肉由来線維芽細胞の付着2007

    • Author(s)
      布施 恵
    • Journal Title

      日本再生歯科医学会誌 5

      Pages: 3-10

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation and tissue response of lipid-coated b-FGF2007

    • Author(s)
      Tohru Hayakawa
    • Journal Title

      Journal of Oral Tissue Engineering 5

      Pages: 96-103

    • NAID

      110006571215

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystallinity controlled apatites through a Ca-EDTA complex and their porous composites with PLGA

    • Author(s)
      Chihiro S. Mochizuki, Tohru Hayakawa, (他7名,5番目)
    • Journal Title

      J Biomedical Mater Res Part B(In press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thin Apatite Coating on Titanium by Molecular Precursor Method

    • Author(s)
      Yamanishi Yasufumi, Tsuneda Yukinari, Izumi Atsuyoshi, Furuta Nobuaki, Hayakawa Tohru
    • Journal Title

      日本口腔インプラント誌 (In press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] EDTA/Ca錯体を用いた結晶性の異なるアパタイト合成およびそのPLGA複合体の骨適合性2008

    • Author(s)
      早川 徹,望月千尋,原 広樹,佐藤光史
    • Organizer
      日本バイオマテリアル学会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-11-17
    • Related Report
      2008 Final Research Report
  • [Presentation] EDTA/Ca錯体を用いた結晶性の異なるアパタイト合成およびそのPLGA複合体の骨適合性2008

    • Author(s)
      早川 徹
    • Organizer
      日本バイオマテリアル学会シンポジウム2008
    • Place of Presentation
      東京
    • Year and Date
      2008-11-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] トレシルクロリド法によるフィブロネクチン由来ペプチド(GRGDSP)のチタン表面への固定化および細胞培養実験2008

    • Author(s)
      早川 徹,Kamolparn Pugdee, 山道信之,吉成正雄,安孫子宣光
    • Organizer
      第6回日本再生歯科医学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2008-09-30
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Biological Effect of Thin Carbonatecontaining Apatite Coating of Titanium Web2008

    • Author(s)
      T. Hayakawa, M. Yoshinari, M. Sato
    • Organizer
      8th World Biomaterials Congress
    • Place of Presentation
      オランダ
    • Year and Date
      2008-05-30
    • Related Report
      2008 Final Research Report
  • [Presentation] Biological Effect of Thin Carbonate- containing Apatite Coating of Titanium Web2008

    • Author(s)
      Tohru Hayakawa
    • Organizer
      8^<th> World Biomaterials Congress
    • Place of Presentation
      オランダ
    • Year and Date
      2008-05-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 分子プレカーサー法によるチタンウェブへのアパタイト薄膜形成と骨適合性2007

    • Author(s)
      早川 徹,吉成正雄,佐藤光史
    • Organizer
      第29回日本バイオマテリアル学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2007-11-26
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] トレシルクロリド法を用いたチタン表面へのタンパク質固定とその生物学的効果2007

    • Author(s)
      早川 徹,Kamolparn Pugdee, 柴田恭子,吉成正雄,安孫子宣光
    • Organizer
      第5回日本再生歯科医学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2007-09-22
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] DNA/キトサン複合体の特性および加工性2007

    • Author(s)
      早川 徹,福島忠男,川口 稔,井上勇介,岡畑恵雄
    • Organizer
      第36回医用高分子シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-07-31
    • Related Report
      2008 Final Research Report 2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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