Analysis on tissue reactions to tissue-engineered cartilage in transgenic mice and optimization of scaffolds
| Project/Area Number |
19592283
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
FUJIHARA Hisako The University of Tokyo, 医学部・附属病院, 医員 (80396746)
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| Co-Investigator(Kenkyū-buntansha) |
HOSHI Kazuto 東京大学, 医学部・附属病院, 特任准教授 (30344451)
CHIKAZU Daichi 東京大学, 医学部・附属病院, 病院講師 (30343122)
MATSUZAKI Masako 東京大学, 医学部・附属病院, 助教 (80313154)
OHASHI Katsumi 東京大学, 医学部・附属病院, 助教 (60233235)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 移植・再生医療 / 再生医学 / 軟骨 / 足場素材 / 再生軟骨 / 組織反応 |
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| Research Abstract |
顎顔面領域において、より機能的で形態的にも優れた再生軟骨移植法を確立するため、再生組織の変形や形成不全の原因となる移植後組織反応を解析した。耳介軟骨細胞とポリ乳酸足場素材で構築される再生軟骨を、免疫不全マウスや遺伝子改変マウスの皮下へ移植し、組織学的、生化学的に検討を行った。足場素材のみを移植した場合と比較し、再生軟骨では惹起される組織反応が低く、移植された軟骨細胞が積極的に免疫反応に関与することにより再生軟骨の成熟に貢献している可能性が示唆された。
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Report
(3 results)
Research Products
(37 results)
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[Journal Article] An animal model study for tissue-engineered trachea fabricated from a biodegradable scaffold using chondrocytes to augment repair of tracheal stenosis2008
Author(s)
Komura M, Komura H, Kanamori Y, Tanaka Y, Suzuki K, Sugiyama M, Nakahara S, Kawashima H, Hatanaka A, Hoshi K, Ikada Y, Tabata Y, Iwanaka T.
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Journal Title
J Pediatr Surg 43
Pages: 2141-2146
Related Report
Peer Reviewed
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[Journal Article] Optimal combination of soluble factors for tissue engineering of permanent cartilage from cultured human chondrocytes2007
Author(s)
Liu G, Kawaguchi H, Ogasawara T, Asawa Y, Kishimoto J, Takahashi T. Chung UI, Yamaoka H, Asato H, Nakamura K, Takato T, Hoshi H.
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Journal Title
J Biol Chem. 282
Pages: 20407-20415
Related Report
Peer Reviewed
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[Journal Article] Effects of transforming growth factor(TGF)-b1 in combination with fibroblast growth factor(FGF)-2 and insulin-like growth factor(IGF)-I on chondrocytes proliferation culture for the cartilage regenerative medicine
Author(s)
Ogasawara T, Ohba S, Fujihara Y, Takahashi T, Liu G, Chikazu D, Suenaga H, Chung UI, Yoda T, Mori Y, Susami T, Takato T, Hoshi K.
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Journal Title
Asian J Oral Maxillofac Surg (in press)
Related Report
Peer Reviewed
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[Journal Article] Selection of highly osteogenic and chondrogenic cells from bone marrow stromal cells in biocompatible polymer-coated plates
Author(s)
Liu G, Iwata K, Ogasawara T, Watanabe J, Fukazawa K, Ishihara K, Asawa Y, Fujihara Y, Chung UI, Moro T, Takatori Y, Takato T, Nakamura K, Kawaguchi H, Hoshi K
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Journal Title
J Biomed Mater Res (in press)
Related Report
Peer Reviewed
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