Development of an oral appliance that induces mandibular protrusion only when sleep apnea occurs and that positive pressure is driven if the apnea disappears

• Project/Area Number: 19592292
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Department of Clinical Research, National Hospital Organization Kyoto Medical Center
• Principal Investigator: YOSHIDA Kazuya Department of Clinical Research, National Hospital Organization Kyoto Medical Center, 臨床研究企画運営部, 研究員 (90263087)
• Co-Investigator(Kenkyū-buntansha): CHIN Kazuo 京都大学, 医学研究科, 教授 (90197640)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 睡眠時無呼吸症候群 / 口腔内装置 / CPAP / 経鼻持続陽圧呼吸療法 / 下顎運動 / 持続陽圧呼吸療法 / 神経生理学

Research Abstract

We tried to develop an oral appliance that induces mandibular protrusion only when sleep apnea occurs and that positive pressure is driven if the apnea disappears. We attempted to change a soft program of continuous positive airway pressure but during the study period did not make it. The research is necessary further investigation.
The somatosensory evoked magnetic field analysis of electrical stimulation of the tongue was found to be useful to get information about finding and developing a sense of tongue and sleep apnea syndrome.
Measuring cerebral blood flow using near-infrared spectroscopy in patients with sleep apnea syndrome, dysfunction of the frontal lobe was elucidated with the syndrome.

Research Products

• [Journal Article] 脳磁図計測における歯科用金属に由来するアーチファクト (2010)
  • Author(s): 前澤仁志, 松橋眞生, 吉田和也, 澤本伸克, 美馬達哉, 長峯隆, 別所和久, 福山秀直
  • Journal Title: 認知神経科学 11 Pages: 258-267
  • NAID: 40016959062
  • Peer Reviewed
• [Journal Article] Associations between obstructive sleep apnea, metabolic syndrome and sleep duration, as measured with an actigraph, in an urban male working population in Japan (2010)
  • Author(s): Chin K, Oga T, Takahashi K, Takegami M, Nakayama-Ashida Y, Wakamura T, Sumi K, Nakamura T, Horita S, Oka Y, Minami I, Fukuhara S, Kadotani H
  • Journal Title: Sleep 33 Pages: 89-95
  • Peer Reviewed
• [Journal Article] 脳磁図計測における歯科用金属に由来するアーチファクト. (2010)
  • Author(s): 前澤仁志, 松橋眞生, 吉田和也, ほか
  • Journal Title: 認知神経科学 11 Pages: 258-267
  • NAID: 40016959062
  • Peer Reviewed
• [Journal Article] 口腔内装置治療の有効性と限界および顎矯正手術の展開 (2009)
  • Author(s): 吉田和也
  • Journal Title: 最新医学睡眠時無呼吸症候群特集号 64 Pages: 76-88
• [Journal Article] Shortened dental arch and cerebral regional blood volume-an experimental study with optical topography- (2009)
  • Author(s): Miyamoto I, Yoshida K, Bessho K
  • Journal Title: J Craniomandibular Practice 27 Pages: 94-100
  • Peer Reviewed
• [Journal Article] apnea with intermittent hypoxia on platelet aggregability (2009)
  • Author(s): T, Chin K, Tabuchi A, Sumi K, Takahashi K, Handa T, Takahashi K, Taniguchi R, Kondo H, Kawato M, Morimoto T, Mishima M, Kita T, Horiuchi H
  • Journal Title: Journal of Atherosclerosis and Thrombosis 16 Pages: 862-869
  • Peer Reviewed
• [Journal Article] Abnormal Swallowing reflex and Chronic Obstructive Pulmonary Disease Exacerbations (2009)
  • Author(s): Terada K, Muro S, Ohara T, Kudo M, Ogawa E, Hoshino Y, Hirai T, Niimi A, Chin K, Mishima M
  • Journal Title: Chest 137 Pages: 326-332
  • Peer Reviewed
• [Journal Article] Importance of ventilator mode in long-term noninvasive positive pressure ventilation (2009)
  • Author(s): Tsuboi T, Oga T, Machida K, Chihara Y, Matsumoto H, Niimi A, Sumi K, Ohi M, Mishima M, Chin K
  • Journal Title: Respir Med (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Body mass index in male patients with chronic obstructive pulmonary disease; correlation with low attenuation areas on CT (2009)
  • Author(s): Ogawa E, Nakano Y, Ohara T, Muro S, Hirai T, Sato S, Sakai H, Tsukino M, Kinose D, Nishioka M, Niimi A, Chin K, Pare PD, Mishima M
  • Journal Title: Thorax 64 Pages: 20-25
  • Peer Reviewed
• [Journal Article] Development of a Japanese version of the Epworth Sleepiness Scale (JESS) based on Item Response Theory (2009)
  • Author(s): Takegami M, Suzukamo Y, Wakita T, Noguchi H, Chin K, Kadotani H, Inoue Y, Oka Y, Nakamura T, Green J, Johns MW, Fukuhara S
  • Journal Title: Sleep Medicine Pages: 556-565
  • Peer Reviewed
• [Journal Article] Prophylactic respiratory management after liver resection with bilevel positive airway pressure ventilation: Report of three cases (2009)
  • Author(s): Narita M, Hatano E, Nagata H, Yanagida A, Asechi H, Takahashi K, Ikai I, Chin K
  • Journal Title: Surgery Today 39 Pages: 172-174
  • NAID: 10025131377
  • Peer Reviewed
• [Journal Article] 口腔内装置治療の有効性と限界および顎矯正手術の展開. (2009)
  • Author(s): 吉田和也
  • Journal Title: 最新医学 64 Pages: 76-88
• [Journal Article] Shortened dental arch and cerebral regional blood volume-an experimental study with optical topography-. (2009)
  • Author(s): Miyamoto I, Yoshida K, et al.
  • Journal Title: Journal of Craniomandibular Practice 27 Pages: 94-100
  • Peer Reviewed
• [Journal Article] 口腔内装置治療の有効性と限界および顎矯正手術の展開 (2009)
  • Author(s): 吉田和也
  • Journal Title: 最新医学 64 Pages: 76-88
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 吉田和也
  • Journal Title: 睡眠に関する口腔衛生. 本田和樹, 福田一彦, 塩見利明ほか編, 睡眠学(朝倉書店) Pages: 644-648
• [Journal Article] Modified Epitec System abutment for magnetic retention of orbital prostheses (2008)
  • Author(s): Yoshida K, Takagi A, Tsuboi Y, Bessho K
  • Journal Title: Journal of Prosthodontics 17 Pages: 219-222
  • Peer Reviewed
• [Journal Article] Somatosensory evoked magnetic fields following the tongue stimulation using needle electrodes (2008)
  • Author(s): Maezawa H, Yoshida K, Nagamine T, Matsubayashi J, Enatsu R, Bessho K, Fukuyama H
  • Journal Title: Neuroscience Research 62 Pages: 131-139
  • Peer Reviewed
• [Journal Article] Computed Tomography analysis of airway dimensions and lung density in patients with sarcoidosis (2008)
  • Author(s): Handa T, Nagai S, Hirai T, Chin K, Kubo T, Oga T, Niimi A, Matsumoto H, Ito Y, Takahashi K, Watanabe K, Izumi T, Mishima M
  • Journal Title: Respiration 77 Pages: 273-281
  • Peer Reviewed
• [Journal Article] Relationship between pulmonary emphysema and osteoporpsis assessed by CT in patients with COPD (2008)
  • Author(s): Ohara T, Hirai T, Muro S, Haruna A, Terada K, Kinose D, Marumo S, Ogawa E, Hoshino Y, Niimi A, Chin K, Mishima M
  • Journal Title: Chest 134 Pages: 1244-1249
  • Peer Reviewed
• [Journal Article] Acylated ghrelin level in patients with obstructive sleep apnoea before and after nasal CPAP treatment (2008)
  • Author(s): Takahashi K, Chin K, Akamizu T, Morita S, Sumi K, Oga T, Matsumoto H, Niimi A, Tsuboi T, Fukuhara S, Kangawa K, Mishima M
  • Journal Title: Respirology 13 Pages: 810-816
  • Peer Reviewed
• [Journal Article] Plasma thioredoxin, a novel oxidative stress marker, in patients with obstructive sleep apnea before and after nasal continuous positive airway pressure (2008)
  • Author(s): Takahashi K, Chin K, Nakamura H, Morita S, Sumi K, Oga T, Matsumoto H, Niimi A, Fukuhara S, Yodoi J, Mishima M
  • Journal Title: Antioxidants, Redox Signaling 10 Pages: 715-726
  • Peer Reviewed
• [Journal Article] Sleep-disordered breathing in the usual lifestyle setting as detected with home monitoring in a Japanese male working population (2008)
  • Author(s): Nakayama-Ashida Y, Takegami M, Chin K, Sumi K, Nakamura T, Takahashi K, Wakamura T, Horita S, Oka Y, Minami I, Fukuhara S, Kadotani H
  • Journal Title: Sleep 31 Pages: 419-425
  • Peer Reviewed
• [Journal Article] Kansai Community Acquired Pneumococcal Pneumonia Study Group. Molecular characteristics of serotype 3 Streptococcus pneumoniae isolates among community-acquired pneumonia patients in Japan (2008)
  • Author(s): Isozumi R, Ito Y, Ishida T, Hirai T, Ito I, Maniwa K, Hayashi M, Kagioka H, Hirabayashi M, Onaru K, Tomioka H, Tomii K, Gohma I, Osawa M, Imai S, Takakura S, Iinuma Y, Chin K, Ichiyama S, Mishima M
  • Journal Title: J Infect Chemother 14 Pages: 258-261
  • Peer Reviewed
• [Journal Article] Somatosensory evoked magnetic fields following electric tongue stimulation using pin electrodes (2008)
  • Author(s): Maezawa H, Yoshida K, Nagamine T, Matsubayashi J, Enatsu R, Bessho K, Fukuyama H.
  • Journal Title: Neuroscience Research 62 Pages: 131-139
  • Peer Reviewed
• [Journal Article] (2008)
  • Author(s): 吉田和也
  • Journal Title: 口腔内装置(閉塞型に対して). 麻野井英次編, 睡眠時無呼吸症候群-循環器臨床に必要な知識(メジカルレビュー社) Pages: 225-232
• [Journal Article] Modified hygienic Epitec System abutment for magnetic retention of orbital prostheses. (2008)
  • Author(s): Yoshida K, Takagi A, Tsuboi Y, Bessho K.
  • Journal Title: Journal of Prosthodontics 17 Pages: 219-222
  • Peer Reviewed
• [Journal Article] 睡眠時無呼吸症候群の治療と予後3. 口腔内装置 (2007)
  • Author(s): 吉田和也
  • Journal Title: Mebio睡眠時無呼吸症候群特集号 24 Pages: 124-138
• [Journal Article] 睡眠時無呼吸症候群の治療と予後 3.口腔内装置 (2007)
  • Author(s): 吉田和也.
  • Journal Title: 月刊Mebio睡眠時無呼吸症候群特集号 24 Pages: 124-138
• [Presentation] 閉塞型睡眠時無呼吸症候群の治療と今後の展望 (2010)
  • Author(s): 吉田和也
  • Organizer: 京都府社会保険診療報酬支払基金歯科学術講演会
  • Place of Presentation: 京都
  • Year and Date: 2010-02-23
• [Presentation] 歯周病と口腔ケア (2009)
  • Author(s): 吉田和也
  • Organizer: 京都医療センター
  • Place of Presentation: 京都
  • Year and Date: 2009-06-15
• [Presentation] 口腔顎顔面領域の筋緊張異常に起因する疾患の診断と治療 (2009)
  • Author(s): 吉田和也
  • Organizer: 大阪歯科大学
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-28
• [Presentation] Effect of oral appliance therapy on blood pressure and its neurophysiological mechanism. The 6th Congress of Asian Sleep Research Society (2009)
  • Author(s): Yoshida K
  • Organizer: The 34th Annual Meeting of Japanese Society of Sleep Research and The 16th Annual Meeting of Japanese Society for Chronobiology Joint Congress
  • Place of Presentation: Osaka
• [Presentation] Effect of oral appliance therapy on blood pressure and its neurophysiological mechanism. (2009)
  • Author(s): Yoshida K.
  • Organizer: The 6th Congress of Asian Sleep Research Society, The 34th Annual Meeting of Japanese Society of Sleep Research and The 16th Annual Meeting of Japanese Society for Chronobiology Joint Congress.
  • Place of Presentation: Osaka
• [Presentation] ピン電極を用いた舌の電気刺激による体性感覚誘発脳磁場反応の解析 (2008)
  • Author(s): 前澤仁志, 吉田和也, 長峯隆, 松林潤, 江夏怜, 別所和久, 福山秀直
  • Organizer: 第156回京都歯科口腔外科集談会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-20
• [Presentation] 下顎第三大臼歯抜歯時に生じた舌神経損傷にMicroneurosurgeryを行った1例- (2008)
  • Author(s): 松本隆司, 東條格, 根来健二, 山田大介, 木賀紀文, 藤田茂之, 前澤仁志, 吉田和也
  • Organizer: 第156回京都歯科口腔外科集談会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-20
• [Presentation] Somatosensory evoked magnetic fields in patients with tongue sensory disturbance (2008)
  • Author(s): Maezawa H, Yoshida K, Nagamine T, Yokoyama Y, Matsuhashi M, Fukuyama H, Bessho K
  • Organizer: The 16th International Conference on Biomagnetism
  • Place of Presentation: Sapporo
  • Year and Date: 2008-08-26
• [Presentation] 顎口腔領域の不随意運動の診断と治療 (2008)
  • Author(s): 吉田和也
  • Organizer: 第155回京都歯科口腔外科集談会
  • Place of Presentation: 京都
  • Year and Date: 2008-07-19
• [Presentation] 顎口腔領域の不随意運動の診断と治療 (2008)
  • Author(s): 吉田和也
  • Organizer: 第155回 京都歯科口腔外科集談会
  • Place of Presentation: 京都
  • Year and Date: 2008-07-19
• [Presentation] 体性感覚誘発脳磁場を用いた舌感覚異常の客観的評価 (2008)
  • Author(s): 前澤仁志, 吉田和也, 長峯隆, 横山洋平, 松橋眞生, 福山秀直, 別所和久
  • Organizer: 第62回日本口腔科学会
  • Place of Presentation: 福岡市
  • Year and Date: 2008-04-18
• [Presentation] 体性感覚誘発脳磁場を用いた舌感覚異常の客観的評価 (2008)
  • Author(s): 前澤仁志, 吉田和也, 長峯隆, 横山洋平, 松橋眞生, 福山秀直, 別所和久
  • Organizer: 第62回日本口腔科学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-04-18
• [Presentation] 歯周病と生活習慣病の関連 (2008)
  • Author(s): 吉田和也
  • Organizer: 榊原白鳳病院生活習慣病セミナー
  • Place of Presentation: 津
  • Year and Date: 2008-02-23
• [Presentation] 睡眠時無呼吸症候群の歯科口腔外科的治療法 (2008)
  • Author(s): 吉田和也
  • Organizer: 松本歯科大学病院セミナー
  • Place of Presentation: 塩尻
  • Year and Date: 2008-01-23
• [Presentation] Brain functions in sleep apnea syndrome assessed by near-infrared spectroscopy (2008)
  • Author(s): Yoshida K, Maezawa H, Suzuki K, Yamada M, Ohno J
  • Organizer: 86th General Session, Exhibition of the International Association for Dental Research
  • Place of Presentation: Toronto
• [Presentation] Brain functions in sleep apnea syndrome assessed by near-infrared spectroscopy (2008)
  • Author(s): Yoshida K, Maezawa H, Suzuki K, Yamada M, Ohno J.
  • Organizer: 86th General Session & Exhibition of the International Association for Dental Research
  • Place of Presentation: Toronto
• [Presentation] 舌感覚異常の患者に対する舌刺激体性感覚誘発脳磁場の解析 (2008)
  • Author(s): 前澤仁志,吉田和也, ほか
  • Organizer: 第62回日本口腔科学会学術集会
  • Place of Presentation: 福岡
• [Presentation] 睡眠時無呼吸症候群におけるスプリント治療の技工作業 (2007)
  • Author(s): 吉田和也
  • Organizer: 第153回京都歯科口腔外科集談会
  • Place of Presentation: 京都
  • Year and Date: 2007-07-21
• [Presentation] 舌刺激体性感覚誘発脳磁場の解析 (2007)
  • Author(s): 前澤仁志, 吉田和也, 松林潤, 別所和久, 長峯隆, 福山秀直
  • Organizer: 第37回日本臨床神経生理学会
  • Place of Presentation: 栃木
• [Presentation] Somatosensory evoked magnetic fields following the tongue stimulation (2007)
  • Author(s): Maezawa H, Yoshida K, Matsubayashi J, Bessho K, Nagamine T, Fukuyama H
  • Organizer: First Conference of International Society for the Advancement of Clinical Magnetoencephalography
  • Place of Presentation: Sendai
• [Presentation] 舌刺激体性感覚誘発脳磁場の解析. (2007)
  • Author(s): 前澤仁志,吉田和也, ほか
  • Organizer: 第37回日本臨床神経生理学会
  • Place of Presentation: 栃木
• [Presentation] Somatosensory evoked magnetic fields following the tongue stimulation. (2007)
  • Author(s): Maezawa H, Yoshida K, et. al.
  • Organizer: First Conference of International Society for the Advancement of Clinical Magnetoencephalography
  • Place of Presentation: Sendai
• [Book] Sleep apnea syndrome from clinical and neurophysiological aspects in the stomatognathic system (2010)
  • Author(s): Yoshida K
  • Publisher: Nova Science Publishers
• [Book] Sleep apnea syndrome from clinical and neurophysiological aspects in the stomatognathic system. (2010)
  • Author(s): Yoshida K.
  • Total Pages: 123
  • Publisher: Nova Science Publishers, New York
• [Book] 睡眠に関する口腔衛生 (2009)
  • Author(s): 吉田和也
  • Publisher: 朝倉書店
• [Book] Treatment and research of sleep apnea syndrome from clinical and neurophysiological aspects in the stomatognathic system. In : Columbus F (ed) : New sleep apnea syndrome research (2009)
  • Author(s): Yoshida K.
  • Publisher: Nova Science Publishers(印刷中)
• [Book] 口腔内装置(閉塞型に対して). 麻野井英次編, 睡眠時無呼吸症候群-循環器臨床に必要な知識 (2008)
  • Author(s): 吉田和也
  • Publisher: メジカルレビュー社
• [Book] 顎顔面領域の不随意運動, 口と歯の事典 (2008)
  • Author(s): 宮脇正一, 吉田和也
  • Publisher: 朝倉書店
• [Book] 顎顔面領域の不随意運動.高戸 毅,天笠光男,葛西一貴ほか編,口と歯の事典 (2008)
  • Author(s): 宮脇正一,吉田和也.
  • Total Pages: 422
  • Publisher: 朝倉書店
• [Book] 睡眠に関する口腔衛生.本田和樹,福田一彦,塩見利明ほか編,睡眠学 (2008)
  • Author(s): 吉田和也.
  • Publisher: 朝倉書店(印刷中)
• [Book] IX-4.口腔内装置(閉塞型に対して).麻野井英次編,睡眠時無呼吸症候群-循環器臨床に必要な知識. (2008)
  • Author(s): 吉田和也.
  • Publisher: メジカルレビュー社(印刷中)
• [Book] Treatment and research of sleep apnea syndrome from clinical and neurophysiological aspects in the stomatognathic system. In : Columbus F(ed) : New sleep apnea syndrome research. (2008)
  • Author(s): Yoshida K.
  • Publisher: Nova Science Publishers(印刷中)
• [Remarks] 吉田和也.睡眠時無呼吸症候群の口腔内装置治療.「カラダ元気」FM845 2008年7月29日