| Project/Area Number |
19592300
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
|
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| Research Institution | Kochi University |
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Principal Investigator |
OSAKI Tokio Kochi University, 名誉教授 (70031995)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Tetsuya 高知大学, 教育研究部医療学系, 教授 (00200824)
UETA Eisaku 高知大学, 教育研究部医療学系, 講師 (10203431)
KAMATANI Takaaki 高知大学, 医学部附属病院, 助教 (00315003)
SASABE Eri 高知大学, 教育研究部医療学系, 助教 (40363288)
SATAKE Hidetaka 高知大学, 教育研究部医療学系, 助教 (10304685)
TATEISHI Yoshihisa 高知大学, 医学部附属病院, 助教 (20372732)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 口腔扁平上皮癌 / DNA損傷 / 放射線 / Rad51 / 17-AAG / アポトーシス / 相同組み換え / DNA損傷修復 / OGG1 / POLG / Tfam |
|---|
| Research Abstract |
An inhibitor of heat shock protein 90, 17-AAG, inhibits homologous recombination mechanism to repair DNA damage in oral squamous cell carcinoma cells via the inhibition of Rad51 expression. The combination of 17-AAG with ionizing irradiation seems to be a useful strategy for oral cancer treatment.
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