The responses of the temporomandibular synovial cells by the hydrostatic pressure

• Project/Area Number: 19592307
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Nara Medical University
• Principal Investigator: 川上 哲司 Nara Medical University, 医学部, 講師 (60254512)
• Co-Investigator(Kenkyū-buntansha): TANAKA Yasuharu 琉球大学, 医学部, 教授 (20124878)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 歯学 / 顎関節 / 滑膜細胞

Research Abstract

本研究より、咬合圧と顎関節腔内圧は正の相関をもち、内圧の亢進は滑膜細胞の誘導型一酸化窒素合成酵素を誘導することが示された。これは、噛みしめによる静水圧ストレスが、顎関節腔内の酸化ストレスを高める可能性を示唆し、噛みしめなどの習癖が顎関節症の誘因になり得ることを示すものである。

Research Products

• [Journal Article] MMP-3 activation is a hallmark indicating an early change in TMJ disorders, and is related to nitration (2009)
  • Author(s): Fujita H, Morisugi T, Tanaka Y, Kawakami T, Kirita T, Yoshimura Y
  • Journal Title: Int. J Oral Maxillofac Surg. 38 Pages: 70-78
  • Peer Reviewed
• [Journal Article] Heat stress promotes the degradation of p53 and p300/GBP-associated factor in murine embryonic fibroblasts. (2007)
  • Author(s): Tanaka Y, Morisugi T, Hironaka A
  • Journal Title: Ryukyu Med. J. 26 Pages: 113-123
• [Presentation] ウサギ滑膜線維芽細胞における機械的伸展に伴うNF-κBの活性化を介したCOX-2とiNOSの発現誘導 (2008)
  • Author(s): 森杉敏明、川上哲司、田中康春、桐田忠昭
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] Clinical application of a high frequency electric knife with Coblation technology for temporomandibular joint arthroscopic surgery. (2007)
  • Author(s): Kawakami T., Inoue T., Ogawa J., Fujita H., Kirita T.
  • Organizer: 89^<th> annual meeting, scientific sessions & exhibition in conjunction with the Japanease society of OMS and the Korean association of OMS
  • Place of Presentation: Honolulu,Hawaii