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免疫応答をマーカーとしたセンチネルリンパ節微少転移診断

Research Project

Project/Area Number 19592313
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionShowa University

Principal Investigator

OOHASHI Masaru  Showa University, 歯学部, 助教 (40317524)

Co-Investigator(Kenkyū-buntansha) SHINTANI Satoru  昭和大学, 歯学部, 教授 (80294429)
DAISUKE Itoh  東京医科歯科大学, 歯学部, 特任講師 (40286844)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords口腔扁平上皮癌 / センチネルリンパ節 / 免疫応答 / 微少転移 / 遺伝子診断・治療 / 悪性腫瘍 / 転移
Research Abstract

センチネルリンパ節転移検体が予定症例数を満たしていないため特異的遺伝子発現の同定は困難であった。マウス舌癌転移モデルを作成し、In vitro解析を中心に行った。その結果、インテグリンファミリーの関与が示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (2 results)

All Other

All Journal Article (2 results)

  • [Journal Article] S-1 mediates the inhibition of lymph node metastasis in oral cancer cells

    • Author(s)
      Hana Sato, Masashi Hatori, Yuriko Ando, Yuji Kurihara, Sayaka Takayama, Tatsuo Shirota, Tetsuhiko Tachikawa, Satoru Shintani
    • Journal Title

      Oncology reports (in press)

    • Related Report
      2008 Final Research Report
  • [Journal Article] Experience with Sentinel lymph node detection in oral cancer by fluorescence navigation method using indocyanine green

    • Author(s)
      Masaru Ohash, Masashi Hatori, Tatsuo Shirota, Satoru Shintani
    • Journal Title

      Asian J Oral Maxillofacial surg (In press)

    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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