| Project/Area Number |
19592318
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
KONDOH Toshirou Nihon University, 松戸歯学部, 教授 (70178416)
|
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| Co-Investigator(Kenkyū-buntansha) |
ABIKO Yoshimitsu 日本大学, 松戸歯学部, 教授 (70050086)
OGURA Naomi 日本大学, 松戸歯学部, 講師 (10152448)
ABIKO Yoshimitsu 千葉県立保健医療大学, 健康科学部, 教授 (70312048)
ABIKO Yoshimitsu 日本大学, 松戸歯学部, 助手 (20419758)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 顎関節内障 / 顎関節滑膜細胞 / GeneChip解析 / Antibody Array / Chemokine / interluekin-1β / tumor necrosis factor-α / TNF-α / 滑膜炎モデル / IL-1β / IL-6 / COX-2 / PGE2 / ラット顎関節OAモデル / microarray analysis |
|---|
| Research Abstract |
Synovitis that often accompanies intracapsular pathologic conditions is characterized by chronic inflammatory changes in the temporomandibular joint (TMJ). We have investigated of IL-1β or TNF-α-responsive genes in synoviocytes for putative genes associated with the synovitis using microarray analysis because IL-1b and TNF-a elevated in synovial fluids obtained from TMJ with pathologic conditions. Then, the protein levels of IL-1β or TNF-α-responsive factors have been investigated in synovitis models in vitro and in vivo.
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