Antiangiogenic gene therapy with low-dose chemotherapy enhances antitumor activity against oral cancer

• Project/Area Number: 19592322
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kanagawa Dental College
• Principal Investigator: OMI Yasushi Kanagawa Dental College, 歯学部, 助教 (10318892)
• Co-Investigator(Kenkyū-buntansha): LEE Ushaku 神奈川歯科大学, 歯学部, 助教 (90288085) ; MATSUMOTO Goichi 神奈川歯科大学, 歯学部, 准教授 (60199867)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 口腔癌 / 遺伝子治療 / アンジオスタチン / エンドスタチン / NK4 / CDDP / NK-4 / 血管新生 / 化学療法

Research Abstract

抗血管新生遺伝子治療単独群[アンジオスタチンplasmid DNA (100μg)、エンドスタチンplasmid DNA(100 μg)、NK4 plasmid DNA (100 μg)]に比較し、CDDP(1.5mg/kg ; 1週間に5回で3週間継続)併用投与群において有意な腫瘍抑制効果を認めた。

Research Products

• [Presentation] Antiangiogenic gene therapy combined with low-dose chemotherapy suppresses murine squamous cell carcinoma (2007)
  • Author(s): Goichi Matsumoto, Eiro Kubota and Yasuhiko Tabata
  • Organizer: First World Congress of the International Academic of Oral Oncology
  • Place of Presentation: Amsterdam, Netherlands
• [Presentation] Antiangiogenic gene therapy combined with low-dose chemotherapy suppresses murine squamous cell carcinoma. (2007)
  • Author(s): Goichi Matsumoto
  • Organizer: First World Congress of the International Academic of Oral Oncology.
  • Place of Presentation: Amsterdam, Netherlands