| Project/Area Number |
19592323
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
|
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| Research Institution | Kanazawa Medical University |
|---|
Principal Investigator |
KANEYAMA Keiseki Kanazawa Medical University, 医学部, 講師 (50329380)
|
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| Co-Investigator(Kenkyū-buntansha) |
SEGAMI Natsuki 金沢医科大学, 医学部, 教授 (40148721)
NAGAO Toshikazu 金沢医科大学, 医学部, 助教 (70387364)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 顎関節症 / 破骨細胞 / 破骨細胞分化促進因子 / 破骨細胞分化抑制因子 / 滑液 / 滑膜 / ビスフェノールA / 性ホルモン / 顎関節 / ビスフェノール / マウス / 下顎頭 / 環境ホルモン / エストロゲン / 蛋白 / 尿検査試験紙 / pH / 滑幕 / 破骨細胞分化因子(RANKL) / 破骨細胞抑制因子(OPG) / クレアチニン |
|---|
| Research Abstract |
To investigate the possible influences of estrogen on the development of osteoarthritis (OA), the effects of Bisphenol-A (BPA), an analogue of estrogen, on the development of the temporomandibular joints in mice fetuses were examined. The temporomandibular joints was reduced in volume and cell number in the BPA groups. The low concentration groups (0.2-2μg/kg) demonstrated the smallest volume and lowest cell number.BPA administration appeared to affect the development of the mandibular condyle in mice.
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