Experimental study on development and application in beagles with cleft lip/palate

• Project/Area Number: 19592326
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Aichi Gakuin University
• Principal Investigator: FURUKAWA Hiroo Aichi Gakuin University, 心身科学部, 准教授 (70291763)
• Co-Investigator(Kenkyū-buntansha): KOYASU Kazuhiro 愛知学院大学, 歯学部, 講師 (50183348) ; NAITO Munetaka 愛知学院大学, 歯学部, 准教授 (20167539) ; 高橋 久英 藤田保健衛生大学, 衛生学部, 教授 (80084606) ; 豊田 哲郎 愛知学院大学, 心身科学部, 准教授 (10308786)
• Project Period (FY): 2007 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: イヌ / ヒト / 先天異常 / 口唇裂 / 口蓋裂 / 心臓異常 / 大血管異常 / 疾患モデル動物

Research Abstract

The Jpanese breeder network of the beagle was able to be established in the first year. We obtained jaw deformity beagles (for breeding , by two male females) using the network. Aiming at the establishment of the cleft lip and palate natural occurrence beagle system, we tried them as a mating individual. From a reason peculiar to an individual, however, do not readily become pregnant, we were not able to acquire a second cleft lip/palate beagle or jaw deformity beagle.

Research Products

• [Journal Article] 口唇裂患者に認められた上唇部類表皮嚢胞の1例 (2010)
  • Author(s): 加藤大貴
  • Journal Title: 日本障害者歯科学会雑誌 Volume: 31巻2号 Pages: 242-246
  • Peer Reviewed
• [Journal Article] 構音障害に対する治療効果の音響学的考察 (2010)
  • Author(s): 加藤理恵
  • Journal Title: 心身科学 Volume: 2巻1号 Pages: 25-36
  • Peer Reviewed
• [Journal Article] 口唇口蓋裂児の言語発達 第1報-口唇口蓋裂児と機能性構音障害児のWPPSI知能診断検査による評価- (2010)
  • Author(s): 伊藤美知恵
  • Journal Title: 愛知学院大学歯学会誌 Volume: 48(1) Pages: 15-20
  • Peer Reviewed
• [Journal Article] Mutations in BMP4 are associated with subepithelial, microform, and overt cleft lip. (2009)
  • Author(s): Suzuki S, Marazita ML, Cooper ME, Miwa N, Hing A, Jugessur A, Natsume N, Shimozato K, Ohbayashi N, Suzuki Y, Niimi T, Minami K, Yamamoto M, Altannamar TJ, Erkhembaatar T, Furukawa H, Daack-Hirsch S, L'heureux J, Brandon CA, Weinberg SM, Neiswanger K, Deleyiannis FW, de Salamanca JE, Vieira AR, Lidral AC, Martin JF, Murray JC.
  • Journal Title: Am J Hum Genet. 84(3)(Epub 2009 Feb 26) Pages: 406-11
• [Presentation] Epidemiological research about patients with cleft lip and/or palate -Investigation from 1997 to 2008 in Japanese- (2010)
  • Author(s): Yoshikazu Nagase
  • Organizer: Cleft 2010
  • Place of Presentation: Seoul
• [Presentation] 口唇口蓋裂を伴った自然発生顎顔面異常ビーグル犬について (2009)
  • Author(s): 仲間錠嗣
  • Organizer: 第33回日本口蓋裂学会総会・学術集会
  • Place of Presentation: シェーンバッハ・サボー(東京)
  • Year and Date: 2009-05-29
• [Presentation] 口唇・口蓋裂に関する実験的研究 第125報-口唇口蓋裂を伴った自然発生顎顔面異常ビーグル犬について (2009)
  • Author(s): 仲間錠嗣、古川博雄、新美照幸、南克浩、鈴木聡、藤原久美子、井村英人、夏目長門、新垣敬一、天願俊泉、比嘉努、仲宗根敏幸、石川拓、牧志祥子、前川隆子、砂川元
  • Organizer: 第33回日本口蓋裂学会
  • Place of Presentation: 東京
• [Presentation] 自然発生顎顔面異常ビーグル犬についての考察 (2008)
  • Author(s): 仲間錠嗣、古川博雄、新美照幸、南克浩、鈴木聡、藤原久美子、井村英人、牧野日和、新崎章、砂川元、夏目長門
  • Organizer: 第25回日本障害者歯科学会
  • Place of Presentation: 東京
• [Presentation] 自然発生顎顔面異常ビーグル犬についての考察 (2008)
  • Author(s): 仲間 錠嗣
  • Organizer: 第25回日本障害者歯科学会総会および学術大会
  • Place of Presentation: 品川区立総合区民会館きゅりあん