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Functional Analysis of EMT and p63 in the invasiveness and metastasis of Oral cancer

Research Project

Project/Area Number 19592337
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionHiroshima University

Principal Investigator

HIGASHIKAWA Koichiro  Hiroshima University, 大学院・医歯薬学総合研究科, 助教 (80363084)

Co-Investigator(Kenkyū-buntansha) KAMATA Nobuyuki  広島大学, 大学院・医歯薬学総合研究科, 教授 (70242211)
ONO Shigehiro  広島大学, 大学院・医歯薬学総合研究科, 助教 (70379882)
SHIGEISHI Hideo  広島大学, 大学院・医歯薬学総合研究科, 助教 (90397943)
MITANI Yoshitsugu  広島大学, 病院, 歯科診療医 (30432678)
Co-Investigator(Renkei-kenkyūsha) TOBIUME Kei  広島大学, 大学院・医歯薬学総合研究科, 准教授 (40350037)
Research Collaborator YONEDA Shingo  広島大学, 大学院・医歯薬学総合研究科, 大学院生
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords口腔癌 / 上皮・間葉移行 / 癌の浸潤・転移 / p63 / 浸潤・転移
Research Abstract

口腔癌の浸潤・転移において, EMTを誘導するSnailが重要な役割を果たしており, そのSnailが転写制御するp63依存的な浸潤能の解析をおこなった結果, p63が正の発現調節をしているId3がMMP-2の発現を誘導して浸潤能亢進に寄与していることがわかった. しかしp63が生理的に制御する上皮構造形成と癌の浸潤に直接関わる分子機構はまだ明らかでないため, 現在解析を継続している.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (14 results)

All 2009 2008 2007

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (5 results)

  • [Journal Article] DeltaNp63alpha-dependent expression of Id-3 distinctively suppresses the invasiveness of human squamous cell carcinoma2009

    • Author(s)
      Higashikawa K, Yoneda S, Tobiume K, Saitoh M, Taki M, Mitani Y, Shigeishi H, Ono S, Kamata N
    • Journal Title

      Int J Cancer 124(12)

      Pages: 2837-2844

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] DeltaNp63alpha-dependent expression of Id-3 distinctively suppresses the invasiveness of human squamous cell carcinoma.2009

    • Author(s)
      東川 晃一郎
    • Journal Title

      International Journal of Cancer (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression profiling to identify genes associated with high-invasiveness in human squamous cell carcinoma with epithelial-to-mesenchymal transition2008

    • Author(s)
      Higashikawa K, Yoneda S, Taki M, Shigeishi H, Ono S, Tobiume K, Kamata N
    • Journal Title

      Cancer Lett 264(2)

      Pages: 256-264

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] EMTを介した癌の高度浸潤能獲得の分子機構2008

    • Author(s)
      鎌田伸之, 東川晃一郎
    • Journal Title

      細胞工学(依頼総説) 27巻, 4号

      Pages: 359-362

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression profiling to identify genes associated with high-invasiveness in human squamous cell carcinoma with epit helial-to-mesenchymal transition.2008

    • Author(s)
      東川 晃一郎
    • Journal Title

      Cancer Letters 264(2)

      Pages: 256-264

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EMTを介した癌の高度浸潤能獲得の分子機構2008

    • Author(s)
      鎌田 伸之, 東川 晃一郎
    • Journal Title

      細胞工学 27(4)

      Pages: 359-362

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression profiling to identify genes associated with high-invasiveness in human squamous cell carcinoma with epithelial-to-mesenchymal transition.2008

    • Author(s)
      東川 晃一郎
    • Journal Title

      Cancer Letters (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EMTを介した癌の高度浸潤能獲得の分子機構2008

    • Author(s)
      鎌田 伸之
    • Journal Title

      細胞工学 (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Snail-induced down-regulation of DeltaNp63alpha acquires invasive phenotype of human squamous cell carcinoma.2007

    • Author(s)
      東川 晃一郎
    • Journal Title

      Cancer Research 67・19

      Pages: 9207-9213

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Id3 suppresses confined to the invasiveness of human squamous cell carcinoma with epithelial-to-mesenchymal transition.2008

    • Author(s)
      東川 晃一郎
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] EMT型口腔扁平上皮癌の浸潤をId3 は抑制する2008

    • Author(s)
      東川晃一郎, 米田進吾, 飛梅圭, 瀧雅行, 三谷佳嗣, 重石英生, 小野重弘, 鎌田伸之
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Related Report
      2008 Final Research Report
  • [Presentation] EMT型口腔扁平上皮癌細胞の浸潤を抑制するId3の解析2008

    • Author(s)
      東川晃一郎, 米田進吾, 瀧雅行, 田中扶美, 三谷佳嗣, 重石英生, 小野重弘, 鎌田伸之
    • Organizer
      第53回日本口腔外科学会総会
    • Place of Presentation
      徳島市
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 扁平上皮癌細胞におけるEMT標的遺伝子のΔNp63αの発現依存的な浸潤能の変化2007

    • Author(s)
      米田進吾, 東川晃一郎, 瀧雅行, 重石英夫, 小野重弘, 三谷佳嗣, 鎌田伸之
    • Organizer
      第61回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      神戸市
    • Year and Date
      2007-04-20
    • Related Report
      2008 Final Research Report
  • [Presentation] 上皮・間葉移行を介した扁平上皮癌細胞におけるΔNp63αの発現依存的な浸潤能の変化2007

    • Author(s)
      米田進吾, 東川晃一郎, 瀧雅行, 重石英夫, 小野重弘, 三谷佳嗣, 鎌田伸之
    • Organizer
      第80回日本組織培養学会
    • Place of Presentation
      大阪市
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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