Pathobiological Analysis of Odontogenic Tumors and Development of Local Injection Therapy

• Project/Area Number: 19592341
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kyushu University
• Principal Investigator: NINOMIYA Tomohiro Kyushu University, 歯学研究院, 助教 (10346801)
• Co-Investigator(Kenkyū-buntansha): KUBOTA Yasutaka 九州大学, 大学病院, 講師 (60205151) ; SHIRASUNA Kanemitsu 九州大学, 歯学研究院, 教授 (30093420)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 歯学 / 歯原性腫瘍 / 角化嚢胞 / エナメル上皮腫

Research Abstract

The purpose of this study is to analyze odontogenic tumors pathobiologically and then, we try to develop the new therapy with local injection. In our study suggested that Interleukin-1α (IL-1α) play a crucial role in the growth of keratocystic odontogenic tumors (KCOTs). Now, we try to make an antisense of IL-1α for the new therapy with local injection.

Research Products

• [Journal Article] Expression of KGF and its receptor in odontogenic keratocysts. (2009)
  • Author(s): Suyama Y, Kubota Y, Yamashiro T, Ninomiya T, Shirasuna K.
  • Journal Title: Journal of Oral Pathology and Medicine. 38巻 Pages: 476-480
  • Peer Reviewed
• [Journal Article] Expression of KGF and its receptor in odontogenic keratocysts (2009)
  • Author(s): Suyama Y., Kubota Y., Yamashiro T., Ninomiya T., Koji T., Shirasuna K.
  • Journal Title: Journal of Oral Pathology and Medicine 38 Pages: 476-480
  • Peer Reviewed
• [Journal Article] Immunohistochemical analysis of interleukin-1α, its type I receptor and antagonist in keratocystic odontogenic tumors. (2008)
  • Author(s): Suyama Y, Kubota Y, Ninomiya T, Shirasuna K.
  • Journal Title: Journal of Oral Pathology and Medicine. 37巻 Pages: 560-564
  • Peer Reviewed
• [Journal Article] Immunohistochemical analysis of interleukin-lalpha, its type I receptor and antagonist in keratocystic odontogenic tumors. (2008)
  • Author(s): Suyama Y, Kubota Y, Ninomiya T, Shirasuna K.
  • Journal Title: Journal of Oral Pathology and Medicine 37 Pages: 560-564
  • Peer Reviewed
• [Presentation] 歯原性顎骨嚢胞の開窓効果. (2009)
  • Author(s): 今城育美、二宮史浩、窪田泰孝、岡正司、山城崇裕、陶山曜子、矢原佳枝、竹之下康治
  • Organizer: 第54回日本口腔外科学会総会・学術大会.
  • Place of Presentation: 札幌
  • Year and Date: 2009-10-09
• [Presentation] 歯原性顎骨嚢胞の開窓効果 (2009)
  • Author(s): 今城育美, 二宮史浩, 窪田泰孝, 他5名
  • Organizer: 第54回日本口腔外科学会総会・学術大会
  • Place of Presentation: 札幌
  • Year and Date: 2009-10-09
• [Presentation] 角化嚢胞性歯原性腫瘍再発症例の検討. (2008)
  • Author(s): 中村和弘、窪田泰孝、山城崇裕、岡正司、二宮史浩、陶山曜子、矢原佳枝、白砂兼光
  • Organizer: 第53回日本口腔外科学会総会
  • Place of Presentation: 徳島
  • Year and Date: 2008-10-20
• [Presentation] 角化嚢胞性歯原性腫瘍におけるinterleukin-1αとkeratinocyte growth factorの発現に関する検討. (2008)
  • Author(s): 二宮史浩、陶山曜子、窪田泰孝、山城崇裕、矢原佳枝、岡正司、菱川善隆、小路武彦、白砂兼光
  • Organizer: 第49回日本組織細胞化学会総会・学術集会.
  • Place of Presentation: 長崎
  • Year and Date: 2008-10-06
• [Presentation] 角化嚢胞性歯原性腫瘍におけるinterleukin-1 α とkeratinocyte growth factorの発現に関する検討 (2008)
  • Author(s): 二宮史浩, 他8名
  • Organizer: 第49回日本組織細胞化学会総会・学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2008-10-06
• [Presentation] 角化嚢胞性歯原性腫瘍におけるインターロイキン-1αとケラチノサイト増殖因子の発現に関する研究. (2008)
  • Author(s): 陶山曜子、窪田泰孝、二宮史浩、山城崇裕、矢原佳枝、岡正司、白砂兼光
  • Organizer: 第62回日本口腔科学会学術集会.
  • Place of Presentation: 福岡
  • Year and Date: 2008-04-18